Adipocyte Biology Core E

肥胖以脂肪组织过多为特征，与代谢异常有关

Obesity, which is characterized by excess adipose tissue mass, is associated with metabolic abnormalities and systemic inflammation. The mechanism(s) responsible for this relationship is not completely known but likely involves the endocrine functions of adipose tissue. Adipose tissue produces a variety of bioactive substances (i.e. adipokines) with central or peripheral actions that regulate food intake and energy expenditure (1). In addition, plasma concentrations of some adipokines are associated with many features of the Metabolic Syndrome, such as insulin resistance, type 2 diabetes mellitus, dyslipidemia, and coronary artery disease (2). Accordingly, the number of investigators who are interested in the molecular biology and cellular physiology of adipocytes and adipose tissue is increasing. To address this growing interest at Washington University, we conducted a survey of our faculty regarding their interest and need for research services involving adipose tissue. In response to this survey, we propose an Adipocyte Biology Core (ABC), which is specifically tailored to meet the needs of CNRU investigators and faculty in basic and clinical departments who wish to conduct nutrition- or obesity- related adipose tissue research. These services do not overlap with those provided by other cores, and services for adipose tissue cell sizing and macrophage content will be coordinated with the Histology Core of the Diabetes Research and Training Center to maximize efficiency and cost-effectiveness. The study of adipose tissue biology requires specific methods, equipment and expertise that are difficult to assemble by individual investigators and present a barrier to those who are new to this field. Therefore, the overall objective of the ABC is to provide CNRU researchers with access to the training, expertise, and facilities needed for comprehensive study of adipose tissue.