Adipocyte Biology Core E

脂肪细胞生物学核心 E

• 批准号: 7116102
• 负责人: Nada A. Abumrad
• 金额: $ 11.19万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7116102
• 关键词: adipocytes; adipose tissue; biomedical facility; clinical research; nutrition; obesity

Obesity, which is characterized by excess adipose tissue mass, is associated with metabolic abnormalities and systemic inflammation. The mechanism(s) responsible for this relationship is not completely known but likely involves the endocrine functions of adipose tissue. Adipose tissue produces a variety of bioactive substances (i.e. adipokines) with central or peripheral actions that regulate food intake and energy expenditure (1). In addition, plasma concentrations of some adipokines are associated with many features of the Metabolic Syndrome, such as insulin resistance, type 2 diabetes mellitus, dyslipidemia, and coronary artery disease (2). Accordingly, the number of investigators who are interested in the molecular biology and cellular physiology of adipocytes and adipose tissue is increasing. To address this growing interest at Washington University, we conducted a survey of our faculty regarding their interest and need for research services involving adipose tissue. In response to this survey, we propose an Adipocyte Biology Core (ABC), which is specifically tailored to meet the needs of CNRU investigators and faculty in basic and clinical departments who wish to conduct nutrition- or obesity- related adipose tissue research. These services do not overlap with those provided by other cores, and services for adipose tissue cell sizing and macrophage content will be coordinated with the Histology Core of the Diabetes Research and Training Center to maximize efficiency and cost-effectiveness. The study of adipose tissue biology requires specific methods, equipment and expertise that are difficult to assemble by individual investigators and present a barrier to those who are new to this field. Therefore, the overall objective of the ABC is to provide CNRU researchers with access to the training, expertise, and facilities needed for comprehensive study of adipose tissue.

以脂肪组织过多为特征的肥胖与代谢异常有关 和全身性炎症。造成这种关系的机制尚不完全清楚， 可能涉及脂肪组织的内分泌功能。脂肪组织产生多种生物活性物质 具有调节食物摄入和能量的中枢或外周作用的物质（即脂肪因子） 支出（1）。此外，某些脂肪因子的血浆浓度与许多特征相关 代谢综合征，如胰岛素抵抗、2型糖尿病、血脂异常和冠状动脉粥样硬化性心脏病。 动脉疾病（2）。因此，对分子生物学感兴趣的研究人员的数量 并且脂肪细胞和脂肪组织的细胞生理学正在增加。为了满足这种日益增长的兴趣， 在华盛顿大学，我们对我们的教师进行了一项关于他们对研究的兴趣和需求的调查 涉及脂肪组织的服务。针对这项调查，我们提出了脂肪细胞生物学核心 (ABC)，这是专门为满足CNRU调查人员和教师的基本需求而量身定制的。 以及希望进行营养或肥胖相关脂肪组织研究的临床部门。 这些服务不与其他核心提供的服务重叠， 大小和巨噬细胞含量将与糖尿病研究的组织学核心协调， 最大限度地提高培训中心的效率和成本效益。脂肪组织生物学的研究需要 调查人员个人难以掌握的具体方法、设备和专门知识， 对那些刚进入这个领域的人来说是一个障碍。因此，ABC的总体目标是 为CNRU研究人员提供所需的培训，专业知识和设施， 脂肪组织的综合研究。