Adipocyte Biology and Molecular Nutrition Core

脂肪细胞生物学和分子营养核心

• 批准号: 8132696
• 负责人: Nada A. Abumrad
• 金额: $ 11.51万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8132696
• 关键词: Adipocytes; Adipose tissue; Area; Biological Assay; Biological Models; Biopsy Specimen; Blood Vessels; Cardiovascular Abnormalities; Cardiovascular Diseases; Cells; Clinical Investigator; Collaborations; Development; Diabetes Mellitus; Eating; Energy Metabolism; Ensure; Equipment; Evaluation; Extracellular Matrix; Fatty Acids; Functional disorder; Gene Expression; Glucose; Glycogen; Hypertrophy; Individual; Inflammation; Instruction; Lead; Lipids; Lipolysis; Liver; Malignant Neoplasms; Mediating; Metabolic; Metabolism; Mitochondria; Molecular; Morphology; Muscle; Nutritional; Obesity; Organ; Phenotype; Play; Process; Publications; Recruitment Activity; Research; Research Activity; Research Infrastructure; Research Personnel; Research Training; Resolution; Resources; Role; Series; System; Technical Expertise; Tissue Expansion; Transfection; Universities; Washington; adipocyte biology; adipocyte differentiation; adipokines; angiogenesis; cost effectiveness; fatty acid oxidation; fatty acid transport; glucose transport; interest; investigator training; lectures; lipid biosynthesis; macrophage; nutrition; operation; programs; protein expression; tissue culture

Adipose tissue function is central to overall metabolism. In addition to its energy storage role, adipose tissue secretes bioactive factors (i.e. adipokines) that contribute to regulating food intake, energy expenditure and normal functioning of key organs such as the vasculature, muscle and liver. Excessive expansion of adipose tissue, as occurs in obesity, is associated with cardiovascular abnormalities and systemic inflammation which ultimately may promote development of cardiovascular disease, diabetes and cancer. Adipose tissue expansion involves processes that include adipocyte hypertrophy, adipogenesis (pre-adipocyte differentiation), angiogenesis (new blood vessel formation) and extracellular matrix remodeling. There is growing interest in targeting these processes as a potentially efficient way to limit adipose tissue mass and obesity. In addition, understanding the molecular mechanisms that mediate lipid storage and the nutritional effects on adipose tissue metabolism are important in the pathophysiology of obesity. The Adipocyte Biology and Molecular Nutrition (ABMN) Core was established in 2006 and has since played a central role in facilitating molecular research related to nutrition and obesity by NORC investigators. The core provides NORC researchers, especially young investigators, access to specific equipment and expertise that are difficult to assemble by individual investigators and that can present a barrier to those new to this field. The state-of-the-art research infrastructure and training available through the ABMN Core facilitate and enhance nutrition/obesity related research and maximize resource use for NORC investigators, particularly young investigators who are establishing independent research programs. The core helps clinical investigators who are interested in the mechanisms underlying the pathophysiology associated with obesity in conducting molecular studies of biopsy samples obtained from metabolically phenotyped subjects. The ABMN core also creates opportunities for interactions and collaborations that often lead to initiation of new multidiscipiinary projects and help recruit basic and clinical investigators to nutrition/obesity related research (see publication record).

脂肪组织功能是整个新陈代谢的中心。除了能量储存作用外，脂肪组织还分泌生物活性因子(即脂肪因子)，有助于调节食物的摄入量、能量消耗和关键器官的正常功能，如血管、肌肉和肝脏。脂肪组织过度膨胀，如肥胖，与心血管异常和全身炎症有关，最终可能会促进心血管疾病、糖尿病和癌症的发展。脂肪组织扩张涉及的过程包括脂肪细胞肥大、脂肪生成(前脂肪细胞 分化)、血管生成(新血管形成)和细胞外基质重建。人们越来越有兴趣将这些过程作为一种潜在的有效方法来限制脂肪组织质量和肥胖。此外，了解调节脂肪储存和营养的分子机制 脂肪组织代谢的影响在肥胖的病理生理学中占有重要地位。脂肪细胞生物学和分子营养核心(ABMN)成立于2006年，自那以来一直在促进NORC调查人员进行与营养和肥胖相关的分子研究方面发挥核心作用。该核心为NORC研究人员，特别是年轻调查人员提供了获得特定设备和专业知识的机会，这些设备和专业知识是 个别调查人员很难组合起来，这可能会给那些刚进入该领域的人带来障碍。通过ABMN核心提供的最先进的研究基础设施和培训促进和加强与营养/肥胖相关的研究，并最大限度地利用资源供NORC调查人员，特别是年轻人使用 正在建立独立研究计划的调查人员。该核心有助于对肥胖相关病理生理学的潜在机制感兴趣的临床研究人员对从代谢表型受试者获得的活检样本进行分子研究。ABMN核心还 为互动和合作创造机会，这往往导致启动新的多学科项目，并帮助招募基础和临床研究人员参与营养/肥胖相关研究(见出版物记录)。