CORE--CELL BIOLOGY/IMMUNOMORPHOLOGY

核心--细胞生物学/免疫形态学

• 批准号: 7311615
• 负责人: DENNIS BROWN
• 金额: $ 16.23万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7311615
• 关键词: biological signal transduction; biomedical facility; cell biology; cell membrane; cellular immunity; confocal scanning microscopy; diabetes mellitus; electron microscopy; endocrinology; fluorescence microscopy; immunocytochemistry; immunofluorescence technique; in situ hybridization; intracellular transport; membrane transport proteins; morphology; pancreatic islets; vascular endothelium

The Cell Biology and Morphology Core will continue to provide individual investigators with technical support, equipment, and expertise for cell biological, morphological and immunocytochemical studies related to the mission of the BADERC application. The projects and interests of the investigators who will participate in the Center can be broken down into three major categories: 1) cell membrane biology and signal transduction; 2) cellular immunology and islet cell biology; and 3) vascular and endothelial cell biology. The first category forms the largest group of users, and it is important to note that the funded studies of the Director of the Core, Dr. Brown, are in the area of membrane biology, membrane proteins, and intracellular trafficking. The Core will, as a major objective, provide an environment appropriate for the training of key personnel from participating laboratories. The rationale for the Core lies in the necessity to provide an integrated approach to problems in diabetes and other designated research areas, in an era when no single laboratory can develop the highest level of technical competence in several important and specialized areas. In addition, the Cell Biology Core is designed to maximize the use and availability of several specialized items of equipment, that are not only prohibitively expensive for many laboratories, but that also require expensive and regular maintenance.

细胞生物学和形态学核心将继续为个体研究者提供与BADERC应用程序的使命相关的细胞生物学、形态学和免疫细胞化学研究的技术支持、设备和专业知识。参与该中心的研究人员的项目和兴趣可以分为三大类：1）细胞膜生物学和信号转导; 2）细胞免疫学和胰岛细胞生物学; 3）血管和内皮细胞生物学。第一类形成了最大的用户群，重要的是要注意到，核心主任Brown博士的资助研究是在膜生物学，膜蛋白和细胞内运输领域。核心的一个主要目标是为培训参与实验室的关键人员提供一个适当的环境。核心的基本原理在于，在一个没有一个实验室能够在几个重要和专业领域发展最高水平的技术能力的时代，有必要为糖尿病和其他指定研究领域的问题提供一种综合方法。此外，细胞生物学核心设计 最大限度地利用和提供几个专业项目的设备，这不仅是 对于许多实验室来说，这是极其昂贵的，但也需要昂贵且定期的维护。