CORE--CELL BIOLOGY/IMMUNOMORPHOLOGY

细胞生物学和形态核心将继续为个体研究人员提供与BADERC应用程序任务相关的细胞生物学、形态和免疫细胞化学研究的技术支持、设备和专业知识。将参与该中心的研究人员的项目和兴趣可分为三大类：1)细胞膜生物学和信号转导；2)细胞免疫学和胰岛细胞生物学；3)血管和内皮细胞生物学。第一类是最大的使用者群体，必须指出的是，核心主任布朗博士资助的研究领域是膜生物学、膜蛋白和细胞内转运。核心将作为一项主要目标，为培训参与实验室的关键人员提供适当的环境。建立核心的理由在于，在一个没有一个实验室能够在几个重要和专业领域发展出最高水平的技术能力的时代，有必要为糖尿病和其他指定研究领域的问题提供综合方法。此外，还设计了细胞生物学核心 为了最大限度地利用和提供几种专门的设备，不仅是 对于许多实验室来说，成本高得令人望而却步，但这也需要昂贵的定期维护。

The Cell Biology and Morphology Core will continue to provide individual investigators with technical support, equipment, and expertise for cell biological, morphological and immunocytochemical studies related to the mission of the BADERC application. The projects and interests of the investigators who will participate in the Center can be broken down into three major categories: 1) cell membrane biology and signal transduction; 2) cellular immunology and islet cell biology; and 3) vascular and endothelial cell biology. The first category forms the largest group of users, and it is important to note that the funded studies of the Director of the Core, Dr. Brown, are in the area of membrane biology, membrane proteins, and intracellular trafficking. The Core will, as a major objective, provide an environment appropriate for the training of key personnel from participating laboratories. The rationale for the Core lies in the necessity to provide an integrated approach to problems in diabetes and other designated research areas, in an era when no single laboratory can develop the highest level of technical competence in several important and specialized areas. In addition, the Cell Biology Core is designed to maximize the use and availability of several specialized items of equipment, that are not only prohibitively expensive for many laboratories, but that also require expensive and regular maintenance.