CORE--CELL BIOLOGY/IMMUNOMORPHOLOGY

细胞生物学和形态学核心将继续为个体研究者提供技术支持、设备和专业知识，用于与BADERC应用任务相关的细胞生物学、形态学和免疫细胞化学研究。研究方向主要分为三大类：1)细胞膜生物学与信号转导；2)细胞免疫学和胰岛细胞生物学；3)血管和内皮细胞生物学。第一类构成了最大的用户群体，值得注意的是，核心主任布朗博士资助的研究是在膜生物学、膜蛋白和细胞内运输领域。作为一项主要目标，核心将为培训参与实验室的关键人员提供适当的环境。核心的基本原理在于，在一个没有任何一个实验室能够在几个重要和专门领域发展最高水平技术能力的时代，有必要为糖尿病和其他指定研究领域的问题提供综合方法。此外，还设计了细胞生物学核心

The Cell Biology and Morphology Core will continue to provide individual investigators with technical support, equipment, and expertise for cell biological, morphological and immunocytochemical studies related to the mission of the BADERC application. The projects and interests of the investigators who will participate in the Center can be broken down into three major categories: 1) cell membrane biology and signal transduction; 2) cellular immunology and islet cell biology; and 3) vascular and endothelial cell biology. The first category forms the largest group of users, and it is important to note that the funded studies of the Director of the Core, Dr. Brown, are in the area of membrane biology, membrane proteins, and intracellular trafficking. The Core will, as a major objective, provide an environment appropriate for the training of key personnel from participating laboratories. The rationale for the Core lies in the necessity to provide an integrated approach to problems in diabetes and other designated research areas, in an era when no single laboratory can develop the highest level of technical competence in several important and specialized areas. In addition, the Cell Biology Core is designed to maximize the use and availability of several specialized items of equipment, that are not only prohibitively expensive for many laboratories, but that also require expensive and regular maintenance.