CELL BIOLOGY AND CELL IMAGING CORE

细胞生物学和细胞成像核心

• 批准号: 7002131
• 负责人: JOHN A WILLIAMS
• 金额: $ 15.81万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7002131
• 关键词: bioimaging /biomedical imaging; biomedical facility; cell biology; confocal scanning microscopy; digital imaging; molecular /cellular imaging

The Cell Biology and Cell Imaging Core is a new Core that has evolved from aspects of two previous cores, the Cell Biology Core which focused on live cell imaging, and the Histochemistry/Morphology Core which focused on cell structure and the localization of biological molecules in fixed cells. The Cell Imaging Core is designed to provide information on the localization of molecules in live and fixed cells and their changes over time and in response to physiological and pathophysiological perturbation. It is centered around microscopic imaging and quantitative analysis of digital information obtained primarily by last scanning confocal microscopy (LSCM) and multiwavelength fluorescence imaging although traditional electron microscopy of fixed and embedded specimens is also available for fine structure analysis.

细胞生物学和细胞成像核心是一个新的核心，已经从两个方面演变而来， 核心，细胞生物学核心，专注于活细胞成像，以及组织化学/形态学 核心，专注于细胞结构和生物分子在固定细胞中的定位。细胞 Imaging Core旨在提供活细胞和固定细胞中分子定位的信息 及其随时间的变化以及对生理和病理生理干扰的响应。是 以显微成像和主要获得的数字信息的定量分析为中心 通过最后扫描共聚焦显微镜（LSCM）和多波长荧光成像， 固定和包埋样本的传统电子显微镜也可用于精细结构 分析.