Systems and Integrative Biology Training Grant

描述（由申请人提供）：本申请要求继续支持一个培训计划，该计划为攻读博士学位的研究生提供系统和综合生物学的广泛的国家或最先进的培训。学生将学习和应用基因组学、生物信息学、蛋白质组学以及细胞和分子生物学的工具和方法来研究综合系统和有机体生物学。该项目以分子与综合生理学系为中心，因为它长期致力于综合生物学，但学生将从第一年开始进入生物医学科学综合门户项目（PIBS），并可以注册多个博士学位项目。受训人员将获得为期两年的资助。潜在的申请人群体是所有申请PIBS的学生，包括来密歇根学习综合生物学的学生和那些尚未决定入学但后来被综合生物学吸引的学生。培训包括正式的课程和研讨会、教学以及与密歇根大学各个部门的教师一起进行的研究经验。所有学生都将学习系统与综合生理学、细胞生理学、细胞与分子生物学、遗传学和生物化学等研究生课程。其他课程由学生根据自己的兴趣选择。通过在本科生理学课程的教学会议部分，加强了生物学研究的综合方法。学生们还参加每周一次的学生研究研讨会，在研讨会上，他们被要求批判性地评价同龄人的报告。这种广泛的训练进一步加强了每个学生在第二年学习结束时参加书面初步考试，这需要理解从细胞和分子水平到生物体的功能，包括环境和生物体之间的相互作用。拟议培训的一个独特之处在于，所有学生将有两位论文联合主席，而不是更传统的单一主席，其中至少有一位将接受细胞和分子生物学最新技术的培训，另一位是综合生物学家。培训教师由44名杰出的科学家组成，他们都是细胞和分子或系统以及综合生物学方面的专家，并致力于培训个人回答综合生理学相关的问题。

DESCRIPTION (provided by applicant): This application requests continuing support for a training program which provides graduate students studying for the Ph.D. degree with broad state-or-the-art training in Systems and Integrative Biology. Students will learn and apply tools and approaches of genomics, bioinformatics, proteomics as well as cell and molecular biology to the study of integrated systems and organismic biology. The program is centered in the Department of Molecular & Integrative Physiology because of its longstanding commitment to integrative biology but students will enter from an initial year in a combined gateway Program in Biomedical Sciences (PIBS) and can be enrolled in multiple Ph.D. programs. Trainees will be supported for two years. The potential applicant pool is all students applying to PIBS and includes both students who come to Michigan to study integrative biology and those who enter undecided and are then drawn to integrative biology. The training includes formal coursework and seminars, teaching, and research experiences with faculty in a variety of departments at the University of Michigan. All students will take graduate level courses in Systems and Integrative Physiology, Cell Physiology, Cellular and Molecular Biology, Genetics and Biochemistry. Additional courses are selected by the student in accordance with his/her interests. The integrative approach to the study of biology is reinforced by teaching conference sections in an undergraduate physiology course. Students also participate in weekly student research seminars in which they are expected to critically evaluate the presentations of their peers. This broad training is further reinforced by each student taking a written preliminary examination at the end of the second year of study that requires an understanding of function, from the cellular and molecular level to that of the organism including interactions between the environment and the organism. A unique aspect of the proposed training is that all students will have two dissertation co-chairs, rather then the more traditional single chair, at least one of whom will be schooled in the most recent techniques in cellular and molecular biology and one being an integrative biologist. The training faculty consists of 44 outstanding scientists all of whom are expert in either cellular and molecular or systems and integrative biology and committed to training individuals to answer questions of integrative physiological relevance.