Southwest Environmental Health Sciences Center

西南环境健康科学中心

基本信息

  • 批准号:
    7016837
  • 负责人:
  • 金额:
    $ 156.34万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1997
  • 资助国家:
    美国
  • 起止时间:
    1997-04-01 至 2011-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant) The theme that unites the research activities of the Southwest Environmental Health Sciences Center (SWEHSC) is the need to understand the mechanisms by which exposures to environmental agents contribute to human disease. Identifying factors that contribute to human diseases that arise as a consequence of environmental exposures is a prerequisite for the development of strategies designed to minimize both the environmental exposure, and the adverse effects of such exposures. The SWEHSC is a dynamic organization that promotes collaborative, interdisciplinary research, with an emphasis on the detection and prevention of environmentally-mediated diseases. Members of the SWEHSC are organized into three Research Cores (RC) with overlapping spheres of interest; Mechanisms of Environmental Chemical Toxicity (RC1), Pulmonary Toxicology and Lung Disease (RC2), and Chemical-Chromatin Interactions (RC3). The Research Cores provide the scientific foundation that provides the basis for strategies designed to treat or prevent environmental diseases. The research efforts of SWEHSC are complemented by five Facility Cores (FC); Cellular Imaging, Genomics, Proteomics, Synthetic Chemistry, and Bioinformatics. The Facility Cores offer state-of-the-art instrumentation and expertise to assist investigators in developing and utilizing cutting-edge technologies. The Administrative Core provides enrichment programs, including seminars, workshops, an annual Science Fair, newsletters, and supports the activities of the Internal and External Advisory Boards. The SWEHSC is also actively involved in promoting innovative research through the Pilot Project Program, and in the recruitment of new investigators. The Community Outreach and Education Program (COEP) offers environmental health science and toxicology based educational programs that are geared to students (K-12), health professionals, and the public. Through the COEP, the SWEHSC provides service to health organizations, government agencies, and the private sector. Three major inter-dependent goals will provide the focus for the next 5 years of support. The SWEHSC will (1) Facilitate the utilization and integration of" global" systems-centered toxicological approaches (proteomics, toxicogenomics, SNP's, cell and tissue imaging) to basic environmental health science research questions. (2) Facilitate the extension of basic research discoveries into the clinical and public health arenas. SWEHSC faculty, in collaboration with faculty in the Colleges of Public Health, Medicine, Pharmacy, and Nursing, will focus in the general area of novel biomarkers (SNP's, proteins, protein adducts, etc) of susceptibility, particularly within minority populations (Hispanic, Native American). Emerging border health initiatives will play an integral role in developing these new areas of emphasis. (3) Initiate and expand collaborations with sister Centers of Excellence on the University of Arizona Health Sciences Center campus (e.g., Arizona Respiratory Center, The University of Arizona Sarver Heart Center, Arizona Cancer Center, Arizona Center on Aging, Steele Memorial Children's Research Center and the BIOS Institute). This last goal is synergistic with the objective of extending basic research discoveries into the clinical and public health arenas.
描述(由申请人提供) 团结西南环境健康科学中心(SWEHSC)的研究活动的主题是需要了解暴露于环境因子导致人类疾病的机制。 查明因环境接触而引起的人类疾病的促成因素是制定旨在尽量减少环境接触及其不利影响的战略的先决条件。SWEHSC是一个充满活力的组织,促进合作,跨学科研究,重点是检测和预防环境介导的疾病。 SWEHSC的成员被组织成三个研究核心(RC),具有重叠的兴趣领域;环境化学毒性机制(RC 1),肺毒理学和肺部疾病(RC 2)和化学染色质相互作用(RC 3)。研究核心为旨在治疗或预防环境疾病的战略提供了科学基础。SWEHSC的研究工作由五个设施核心(FC)补充:细胞成像,基因组学,蛋白质组学,合成化学和生物信息学。 设施核心提供最先进的仪器和专业知识,以协助调查人员开发和利用尖端技术。行政核心提供丰富的方案,包括研讨会,讲习班,年度科学博览会,通讯,并支持内部和外部咨询委员会的活动。SWEHSC还通过试点项目计划积极参与促进创新研究,并招募新的研究人员。社区外展和教育计划(COEP)提供面向学生(K-12),卫生专业人员和公众的环境健康科学和毒理学教育计划。SWEHSC通过COEP向卫生组织、政府机构和私营部门提供服务。三个相互依存的主要目标将为今后五年的支持提供重点。SWEHSC将(1)促进利用和整合以“全球”系统为中心的毒理学方法(蛋白质组学,毒理基因组学,SNP,细胞和组织成像),以解决基本的环境健康科学研究问题。 (2)促进将基础研究发现扩展到临床和公共卫生领域。SWEHSC教师与公共卫生,医学,药学和护理学院的教师合作,将专注于易感性的新生物标志物(SNP,蛋白质,蛋白质加合物等)的一般领域,特别是在少数民族人群中(西班牙裔,美洲原住民)。 新出现的边境卫生倡议将在发展这些新的重点领域方面发挥不可或缺的作用。 (3)发起并扩大与亚利桑那大学健康科学中心校园的姐妹卓越中心的合作(例如,亚利桑那呼吸中心、亚利桑那大学萨弗心脏中心、亚利桑那癌症中心、亚利桑那老龄化中心、斯蒂尔纪念儿童研究中心和BIOS研究所)。最后一个目标与将基础研究发现扩展到临床和公共卫生领域的目标是协同的。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Serrine S Lau其他文献

DNA FRAGMENTATION CAUSED BY REACTIVE OXYGEN SPECIES IN VIVO WITHOUT INCREASED 8-OH-dG CONTENTS. • 458
  • DOI:
    10.1203/00006450-199604001-00478
  • 发表时间:
    1996-04-01
  • 期刊:
  • 影响因子:
    3.100
  • 作者:
    Charles V Smith;Sanjiv Gupta;Heather Kleiner;Lynette K Rogers;Serrine S Lau
  • 通讯作者:
    Serrine S Lau
QUANTIFICATION OF PLASMA CORTISOL AND URINARY 6β-HYDROXYCORTISOL IN MOTHER-INFANT PAIRS
母婴对血浆皮质醇和尿 6β-羟皮质醇的定量分析
  • DOI:
    10.1203/00006450-197404000-00177
  • 发表时间:
    1974-04-01
  • 期刊:
  • 影响因子:
    3.100
  • 作者:
    Marjorie G Horning;Serrine S Lau;Amelia Hung;Wanda G Stillwell;Reba M Hill;Louis L Hill
  • 通讯作者:
    Louis L Hill

Serrine S Lau的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Serrine S Lau', 18)}}的其他基金

Retinoid Mediated Protection Against Reactive Oxygen Species Induced Cytotoxicity
类维生素A介导的针对活性氧诱导的细胞毒性的保护
  • 批准号:
    8663913
  • 财政年份:
    2010
  • 资助金额:
    $ 156.34万
  • 项目类别:
Retinoid Mediated Protection Against Reactive Oxygen Species Induced Cytotoxicity
类维生素A介导的针对活性氧诱导的细胞毒性的保护
  • 批准号:
    8462252
  • 财政年份:
    2010
  • 资助金额:
    $ 156.34万
  • 项目类别:
Community Outreach and Education Program
社区外展和教育计划
  • 批准号:
    8056044
  • 财政年份:
    2010
  • 资助金额:
    $ 156.34万
  • 项目类别:
Retinoid Mediated Protection Against Reactive Oxygen Species Induced Cytotoxicity
类维生素A介导的针对活性氧诱导的细胞毒性的保护
  • 批准号:
    7985510
  • 财政年份:
    2010
  • 资助金额:
    $ 156.34万
  • 项目类别:
Retinoid Mediated Protection Against Reactive Oxygen Species Induced Cytotoxicity
类维生素A介导的针对活性氧诱导的细胞毒性的保护
  • 批准号:
    9231148
  • 财政年份:
    2010
  • 资助金额:
    $ 156.34万
  • 项目类别:
Retinoid Mediated Protection Against Reactive Oxygen Species Induced Cytotoxicity
类维生素A介导的针对活性氧诱导的细胞毒性的保护
  • 批准号:
    8272653
  • 财政年份:
    2010
  • 资助金额:
    $ 156.34万
  • 项目类别:
Retinoid Mediated Protection Against Reactive Oxygen Species Induced Cytotoxicity
类维生素A介导的针对活性氧诱导的细胞毒性的保护
  • 批准号:
    8134263
  • 财政年份:
    2010
  • 资助金额:
    $ 156.34万
  • 项目类别:
Proteomic signatures of an early life asthma-protective exposure
生命早期哮喘保护性暴露的蛋白质组学特征
  • 批准号:
    7943940
  • 财政年份:
    2009
  • 资助金额:
    $ 156.34万
  • 项目类别:
Proteomic signatures of an early life asthma-protective exposure
生命早期哮喘保护性暴露的蛋白质组学特征
  • 批准号:
    7830029
  • 财政年份:
    2009
  • 资助金额:
    $ 156.34万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    7027910
  • 财政年份:
    2006
  • 资助金额:
    $ 156.34万
  • 项目类别:

相似海外基金

Design of a long-term evaluation system for naturally contaminated soil based on environmental exposure tests and simple numerical analysis
基于环境暴露试验和简单数值分析的自然污染土壤长期评价体系设计
  • 批准号:
    22KJ1736
  • 财政年份:
    2023
  • 资助金额:
    $ 156.34万
  • 项目类别:
    Grant-in-Aid for JSPS Fellows
Adverse Childhood Experiences and Environmental Exposure on Mental Health of Black Men who have Sex with Men in Southern United States
美国南部男男性行为黑人的不良童年经历和环境暴露对心理健康的影响
  • 批准号:
    486862
  • 财政年份:
    2023
  • 资助金额:
    $ 156.34万
  • 项目类别:
    Miscellaneous Programs
A Novel Spray-On Sensing Platform Technology that Enables Wearable Visual Monitoring of Physiological Data and Environmental Exposure
一种新型喷涂传感平台技术,可实现生理数据和环境暴露的可穿戴视觉监测
  • 批准号:
    10578579
  • 财政年份:
    2023
  • 资助金额:
    $ 156.34万
  • 项目类别:
Multigenerational Persistence of Environmental Exposure
环境暴露的多代持续性
  • 批准号:
    2200648
  • 财政年份:
    2022
  • 资助金额:
    $ 156.34万
  • 项目类别:
    Standard Grant
Investigating environmental and gene-environment contributors to Parkinson's disease risk by coupling quantitative environmental exposure data to iPSC modeling
通过将定量环境暴露数据与 iPSC 建模相结合,调查帕金森病风险的环境和基因环境因素
  • 批准号:
    10572740
  • 财政年份:
    2022
  • 资助金额:
    $ 156.34万
  • 项目类别:
EIRENE PPP: Environmental Exposure Assessment Research Infrastructure Preparatory Phase Project
EIRENE PPP:环境暴露评估研究基础设施准备阶段项目
  • 批准号:
    10048395
  • 财政年份:
    2022
  • 资助金额:
    $ 156.34万
  • 项目类别:
    EU-Funded
Realistic Laboratory Rolling Loading of Bridge Superstructure built using Novel Technologies Combined with Environmental Exposure
采用新技术与环境暴露相结合建造的桥梁上部结构的真实实验室滚动荷载
  • 批准号:
    RGPIN-2017-04196
  • 财政年份:
    2022
  • 资助金额:
    $ 156.34万
  • 项目类别:
    Discovery Grants Program - Individual
Simulation for Environmental Exposure Education (S3E): A Serious Game Platform for Environmental Health Literacy
环境暴露教育模拟(S3E):环境健康素养的严肃游戏平台
  • 批准号:
    10524491
  • 财政年份:
    2022
  • 资助金额:
    $ 156.34万
  • 项目类别:
Investigating the role of neuroinflammation in environmental exposure-induced anxiety disorders
研究神经炎症在环境暴露诱发的焦虑症中的作用
  • 批准号:
    10573948
  • 财政年份:
    2022
  • 资助金额:
    $ 156.34万
  • 项目类别:
Sources and fate of plastic-associated contaminants in the environment- novel analysis strategies to evaluate human and environmental exposure
环境中塑料相关污染物的来源和归宿——评估人类和环境暴露的新颖分析策略
  • 批准号:
    RGPIN-2021-03770
  • 财政年份:
    2022
  • 资助金额:
    $ 156.34万
  • 项目类别:
    Discovery Grants Program - Individual
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了