Glial-neuronal-vascular interactions in a novel transgenic model of Muller cell dysfunction

Muller 细胞功能障碍的新型转基因模型中的胶质-神经元-血管相互作用

• 批准号: nhmrc : 1028393
• 负责人: A/Pr Nigel Barnett
• 金额: $ 41.78万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/glial-neuronal-vascular-cell-dysfunction/110634
• 关键词: Glial; neuronal; vascular; interactions; novel

Muller cell disfunction is a feature shared by many retinal diseases. This project aims to study the contribution of Muller cell dysfunction to retinal neuronal damage and blood-retinal barrier breakdown in a novel transgenic model we recently generated. Results of this study will also be of interest to scientists and clinicians seeking to understand better and treat diseases of the central nervous system in general.

米勒细胞功能障碍是许多视网膜疾病共有的特征。本项目的目的是在我们最近建立的一种新型转基因模型中研究Muller细胞功能障碍对视网膜神经元损伤和血视网膜屏障破坏的贡献。这项研究的结果也将是科学家和临床医生寻求更好地了解和治疗一般的中枢神经系统疾病的兴趣。