Astrocyte Regulation of Ammonia and Glutamate in Neonatal Hypoxia-Ischaemia

星形胶质细胞对新生儿缺氧缺血中氨和谷氨酸的调节

• 批准号: nhmrc : 631414
• 负责人: A/Pr Nigel Barnett
• 金额: $ 34.93万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/astrocyte-regulation-ammonia-hypoxia-ischaemia/98184
• 关键词: Astrocyte; Regulation; Ammonia; Glutamate; Neonatal

Lack of oxygen is a common problem for newborn infants, ocurring during events such as a difficult labour, and can lead to brain damage. We have discovered that a protein in the brain which normally removes ammonia (a toxic product of metabolism) is rapidly lost after a brief period of low oxygen. We propose that a build up of ammonia in the brain may be a key damaging event in hypoxia-related brain injury, and that it will be ameniable to therapeutic intervention.

缺氧是新生儿的常见问题，发生在难产等事件中，并可能导致脑损伤。我们已经发现，大脑中一种蛋白质，通常可以清除氨（一种有毒的代谢产物），但在短暂的低氧状态下，这种蛋白质会迅速流失。我们认为脑内氨的积累可能是缺氧相关脑损伤的关键损害事件，并且它将有助于治疗干预。