Modulating retinal glutamate transport in health and disease

调节健康和疾病中的视网膜谷氨酸转运

• 批准号: nhmrc : 142943
• 负责人: A/Pr Nigel Barnett
• 金额: $ 17.11万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modulating-retinal-glutamate-health-disease/99986
• 关键词: Modulating; retinal; glutamate; transport; health

Damage can occur to nervous tissues like the retina and brain when there is a reduction in the blood supply. This can occur as a result of a blood clot, stroke or the eye disease, glaucoma. These conditions often result in blindness. Much of the neuronal damage is due to the release of an excess of glutamate. Glutamate is a chemical (neurotransmitter) that nerves use to communicate with each other, but it is toxic to nerves when present at high concentrations. This project will investigate the mechanisms that regulate the concentration of glutamate in the retina. If these mechanisms could be made to work more efficiently, they may prevent the build-up of the glutamate and therefore prevent damage to the nerve cells. Understanding these mechanisms will aid in the development of an effective treatment to prevent blindness when there is a blockage of the blood supply to the retina.

当血液供应减少时，视网膜和大脑等神经组织可能会受到损害。这可能是由于血液凝块、中风或眼疾、青光眼造成的。这些情况往往导致失明。许多神经元损伤是由于过量谷氨酸的释放。谷氨酸是一种化学物质（神经递质），神经用来相互交流，但它在高浓度时对神经有毒。本项目将研究调节视网膜中谷氨酸浓度的机制。如果这些机制能够更有效地发挥作用，它们可能会阻止谷氨酸的积累，从而防止对神经细胞的损害。了解这些机制将有助于开发有效的治疗方法，以防止视网膜血液供应阻塞时失明。