Centers for Autism & Develop Disabilities Resarch & Epidemiol:A Case-Cohort Study

自闭症中心

• 批准号: 7281309
• 负责人: M Daniele Fallin
• 金额: $ 102.34万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7281309
• 关键词: Centers; Autism; Develop; Disabilities; Resarch

DESCRIPTION (provided by applicant): Autism Spectrum Disorders (ASD) are severe, life-long neurodevelopmental disorders that confer considerable impairment to individuals as well as a substantial burden to their families. Little is known about the prevalence or correlates of ASDs. Little high quality information is available regarding the phenotypic variation among individuals with ASDs, prevalence of co-morbid conditions, and risk factors that might be related to the development of ASDs. The Centers for Autism and Developmental Disabilities Research and Epidemiology were established in 2001 to investigate causes and correlates of autism. The focus of this second funding cycle is to conduct a multi-site collaborative epidemiologic study to investigate risk and causal factors for Autism Spectrum Disorders (ASDs) and phenotypic subgroups of ASDs using a population-based case-cohort study design. Six sites (California, Maryland, North Carolina, Pennsylvania, Colorado, and Georgia) will collaborate to enroll 2700 children and their families over the 5-year study period. Each site will include approximately 150 children with ASD, 150 with other neurodevelopmental disorders, and 150 general population controls to address specific hypotheses in six broad domains: 1) phenotypic variation in ASD, including the pattern of clustering of core symptoms, timing of onset, cognitive status, and presence of medical and psychiatric co- morbidities; 2) gastrointestinal features that may be associated with ASD, 3) candidate genes and genetic variation among individuals with ASD and how they interact with environmental risk factors, 4) potential for parental infection, immune function, and autoimmunity to be associated with increased ASD risk, 5) potential for parental hormonal and reproductive characteristics to be associated with increased ASD risk, and 6) potential for sociodemographic and lifestyle factors to be associated with increased ASD risk. To address these goals, this study will conduct developmental assessments on the children and collect extensive data on the pre- and perinatal health and environment of the children and their parents via interviews, medical record review, and the collection of biologic samples. This large study of ASD will improve our understanding of how autism differs phenotypically from other disabilities and from typical development. It will also help identify potential risk factors for autism that deserve more attention.

描述（由申请人提供）：自闭症谱系障碍（ASD）是严重的，终身的神经发育障碍，给个人带来相当大的损害，并给他们的家庭带来巨大的负担。关于ASD的患病率或相关性知之甚少。关于ASD个体间的表型变异、合并症的患病率以及可能与ASD发展相关的风险因素，几乎没有高质量的信息。自闭症和发育障碍研究与流行病学中心成立于2001年，旨在调查自闭症的原因和相关因素。第二个资助周期的重点是进行一项多地点合作流行病学研究，使用基于人群的病例队列研究设计调查自闭症谱系障碍（ASD）和ASD表型亚组的风险和因果因素。6个研究中心（加州、马里兰州、北卡罗来纳州、宾夕法尼亚州、科罗拉多和格鲁吉亚）将在5年研究期间合作入组2700名儿童及其家庭。每个研究中心将包括大约150名ASD儿童、150名其他神经发育障碍儿童和150名一般人群对照，以解决六个广泛领域的特定假设：1）ASD的表型变异，包括核心症状的聚集模式、发作时间、认知状态以及医学和精神病共病的存在; 2）可能与ASD相关的胃肠道特征，3）ASD个体中的候选基因和遗传变异以及它们如何与环境风险因素相互作用，4）亲代感染、免疫功能和自身免疫与ASD风险增加相关的可能性，5）父母激素和生殖特征与ASD风险增加相关的可能性，以及6）社会人口统计学和生活方式因素与ASD风险增加相关的可能性。为了实现这些目标，本研究将对儿童进行发育评估，并通过访谈、病历审查和收集生物样本收集有关儿童及其父母产前和围产期健康和环境的广泛数据。这项关于ASD的大型研究将提高我们对自闭症与其他残疾和典型发育的表型差异的理解。它还将有助于确定自闭症的潜在风险因素，值得更多的关注。