California-Arizona Clinical Trials Network Node

加州-亚利桑那州临床试验网络节点

• 批准号: 7497175
• 负责人: James L Sorensen
• 金额: $ 7.5万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7497175
• 关键词: AIDS/HIV problem; Administrative Efficiency; Adoption; Ally; Area; Arizona; Attention; California; Cancer Center Support Grant; Clinic; Clinical; Clinical Treatment; Clinical Trials; Clinical Trials Network; Collaborations; Communication; Communities; Counseling; Country; Data; Development; Disease; Drug abuse; Extramural Activities; Feedback; Florida; Funding; Future; Goals; Guidelines; HIV; Health Personnel; Health Services Research; Heart; Human Resources; Individual; Intervention; Lead; Leadership; Link; Measures; Medical; Methamphetamine; Minority; Mission; Modeling; Monitor; Multi-Institutional Clinical Trial; National Institute of Drug Abuse; Native Americans; Network-based; Participant; Patients; Performance; Pharmaceutical Preparations; Population; Principal Investigator; Progress Reports; Protocols documentation; Range; Recovery; Research; Research Infrastructure; Research Personnel; Research Training; Role; Sampling; San Francisco; Savings; Science; Site; Substance abuse problem; Suggestion; Supervision; Testing; Training; Training Programs; Translational Research; U-Series Cooperative Agreements; Universities; Work; Writing; base; checkup examination; concept; dissemination research; experience; improved; programs; quality assurance; research study; response; tool; treatment program

The University of California, San Francisco (UCSF), in collaboration with the University of Arizona and a contributing group of community treatment programs (CTPs), proposes to continue a cooperative agreement to lead a node in the National Drug Abuse Treatment Clinical Trials Network (CTN). Our research node consists of a Regional Research and Training Center (RRTC) at UCSF that is linked in partnership with researchers and CTPs in California and Arizona. The goal of the research node is to participate in and conduct high-quality multi-site clinical trials of interventions for drug abuse and to guide the development, dissemination, and adoption of effective interventions in the field. In the initial funding period a strong, collaborative infrastructure was established with bi-directional communication among treatment and research communities. The node demonstrated high-quality participation in seven CTN research protocols, including five multi-site clinical trials, the node obtained funding for five studies that used the CTN as a platform for research, and the node is co-leading an emerging clinical trial of HIV rapid testing and counseling. The specific aims of this proposal are to: (1) Participate in clinical trials of treatments for drug abuse. The node makes a special contribution to HIV/AIDS and co-occurring disorders, health services research, and dissemination. (2) Collaborate with the national CTN leadership in research studies, with special attention to patients with co-occurring problems. The CA-AZ Node will co-lead, with the Florida Node, a study of HIV rapid testing and counseling. It also proposes a research concept linking methamphetamine-dependent patients to treatment by using recovery management checkups. (3) Use the CTN as a research platform by conducting at least three extramurally funded studies linked to the CTN. Node personnel will also continue to seek extramural support for "platform studies." (4) Further develop the CTN as a training site by partnering with existing research training programs at UCSF and University of Arizona. We will involve at least one new trainee each year, collaborate with two Native American programs to develop research capacity, and apply for at least one minority supplement to the core grant. (5) Aid in using the CTN as a site for dissemination research by partnering with local, regional, and national activities. Closing the gap between research and treatment is one of the most critical unresolved issues in drug abuse, and the NIDA CTN can have a significant role. Based on the CA-AZ Node's experience, access to unique and hard-to- reach populations, and a knowledgeable team of investigators and CTPs, this research node has the potential to accelerate the advance of clinical trials and translational research in the coming years.

加州大学旧金山分校(UCSF)与亚利桑那大学和一个 社区治疗计划(CTP)贡献小组，建议继续合作协议 在国家药物滥用治疗临床试验网络(CTN)中领导一个节点。我们的研究节点 由加州大学旧金山分校的区域研究和培训中心(RRTC)组成，该中心与 加利福尼亚州和亚利桑那州的研究人员和CTP。研究节点的目标是参与和 开展药物滥用干预措施的高质量多点临床试验，并指导开发， 在实地传播和采取有效的干预措施。在最初的资助期， 通过治疗和研究之间的双向沟通建立了协作基础设施 社区。该节点高质量地参与了CTN的七项研究方案，包括 五项多点临床试验，该节点获得了五项研究的资金，这些研究使用CTN作为平台 该节点正在共同领导一项新的艾滋病毒快速检测和咨询临床试验。 这项提议的具体目的是：(1)参与药物滥用治疗的临床试验。这个 Node在艾滋病毒/艾滋病和共生疾病、卫生服务研究和 传播。(2)在研究研究方面与国家CTN领导层合作，特别关注 有共同问题的患者。CA-AZ节点将与佛罗里达节点共同领导一项关于艾滋病毒的研究 快速检测和咨询。它还提出了一个研究概念，将甲基苯丙胺依赖 采用康复管理体检对患者进行治疗。(3)利用CTN作为研究平台，通过 进行至少三项与CTN有关的外部资助研究。节点人员也将继续 为“平台研究”寻求外部支持。(4)通过以下方式进一步发展CTN作为培训地点 与加州大学旧金山分校和亚利桑那大学现有的研究培训项目合作。我们将参与到 每年至少有一名新学员，与两个美洲原住民项目合作开展研究 能力，并在核心补助金中至少申请一项少数群体补助金。(5)协助使用CTN作为网站 通过与地方、区域和国家活动合作，进行传播研究。缩小差距 研究和治疗之间的差距是药物滥用中最关键的悬而未决的问题之一，而NIDA CTN可以发挥重要作用。根据CA-AZ节点的经验，访问独特且难以 覆盖人群，以及由调查人员和CTP组成的知识渊博的团队，该研究节点具有 有可能在未来几年加快临床试验和转化研究的进展。