California-Arizona Clinical Trials Network Node

加州大学弗朗西斯科分校（UCSF）与亚利桑那大学和 社区治疗计划（CTPs）的贡献小组，建议继续合作协议 领导国家药物滥用治疗临床试验网络（CTN）的一个节点。我们的研究节点 由加州大学旧金山分校的区域研究和培训中心（RRTC）组成，该中心与 加州和亚利桑那州的研究人员和CTPs。研究节点的目标是参与和 开展高质量的药物滥用干预措施的多地点临床试验，并指导药物滥用干预措施的发展， 传播和在实地采取有效的干预措施。在最初的融资期， 建立了合作基础设施，在治疗和研究之间进行双向沟通 社区.该节点高质量地参与了七项CTN研究协议，包括 在五项多中心临床试验中，该节点获得了五项研究的资金，这些研究使用CTN作为平台， 该节点正在共同领导一项新兴的艾滋病毒快速检测和咨询临床试验。 该提案的具体目的是：（1）参与药物滥用治疗的临床试验。的 该节点为艾滋病毒/艾滋病和并发疾病，卫生服务研究做出了特殊贡献， 传播。(2)与国家CTN领导层合作进行研究，特别关注 有并发症的患者。CA-AZ节点将与佛罗里达节点共同领导一项艾滋病毒研究 快速检测和咨询。它还提出了一个研究概念，将甲基苯丙胺依赖 患者通过使用恢复管理检查进行治疗。(3)利用CTN作为研究平台， 进行至少三项与CTN有关的校外资助研究。节点人员也将继续 为“平台研究”寻求校外支持。“（4）进一步发展CTN作为培训场所， 与加州大学旧金山分校和亚利桑那大学现有的研究培训计划合作。我们将参与在 每年至少有一名新学员，与两个美洲原住民项目合作开展研究 能力，并申请至少一个少数民族补充核心赠款。(5)协助使用CTN作为网站 通过与地方、区域和国家活动合作进行传播研究。缩小差距 研究和治疗之间的关系是药物滥用中最关键的未解决问题之一，NIDA CTN可以发挥重要作用。基于CA-AZ节点的经验，获得独特的和难以- 覆盖人群，以及知识渊博的调查人员和CTP团队，该研究节点具有 在未来几年内，有可能加速临床试验和转化研究的进展。

The University of California, San Francisco (UCSF), in collaboration with the University of Arizona and a contributing group of community treatment programs (CTPs), proposes to continue a cooperative agreement to lead a node in the National Drug Abuse Treatment Clinical Trials Network (CTN). Our research node consists of a Regional Research and Training Center (RRTC) at UCSF that is linked in partnership with researchers and CTPs in California and Arizona. The goal of the research node is to participate in and conduct high-quality multi-site clinical trials of interventions for drug abuse and to guide the development, dissemination, and adoption of effective interventions in the field. In the initial funding period a strong, collaborative infrastructure was established with bi-directional communication among treatment and research communities. The node demonstrated high-quality participation in seven CTN research protocols, including five multi-site clinical trials, the node obtained funding for five studies that used the CTN as a platform for research, and the node is co-leading an emerging clinical trial of HIV rapid testing and counseling. The specific aims of this proposal are to: (1) Participate in clinical trials of treatments for drug abuse. The node makes a special contribution to HIV/AIDS and co-occurring disorders, health services research, and dissemination. (2) Collaborate with the national CTN leadership in research studies, with special attention to patients with co-occurring problems. The CA-AZ Node will co-lead, with the Florida Node, a study of HIV rapid testing and counseling. It also proposes a research concept linking methamphetamine-dependent patients to treatment by using recovery management checkups. (3) Use the CTN as a research platform by conducting at least three extramurally funded studies linked to the CTN. Node personnel will also continue to seek extramural support for "platform studies." (4) Further develop the CTN as a training site by partnering with existing research training programs at UCSF and University of Arizona. We will involve at least one new trainee each year, collaborate with two Native American programs to develop research capacity, and apply for at least one minority supplement to the core grant. (5) Aid in using the CTN as a site for dissemination research by partnering with local, regional, and national activities. Closing the gap between research and treatment is one of the most critical unresolved issues in drug abuse, and the NIDA CTN can have a significant role. Based on the CA-AZ Node's experience, access to unique and hard-to- reach populations, and a knowledgeable team of investigators and CTPs, this research node has the potential to accelerate the advance of clinical trials and translational research in the coming years.