California-Arizona Clinical Trials Network Node

加州-亚利桑那州临床试验网络节点

• 批准号: 7684543
• 负责人: James L Sorensen
• 金额: $ 19.46万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7684543
• 关键词: AIDS/HIV problem; Administrative Efficiency; Adoption; Ally; Area; Arizona; Attention; California; Cancer Center Support Grant; Clinic; Clinical; Clinical Treatment; Clinical Trials; Clinical Trials Network; Collaborations; Communication; Communities; Counseling; Country; Data; Development; Disease; Drug abuse; Extramural Activities; Feedback; Florida; Funding; Future; Goals; Guidelines; HIV; Health Personnel; Health Services Research; Heart; Human Resources; Individual; Intervention; Lead; Leadership; Link; Measures; Medical; Methamphetamine; Minority; Mission; Modeling; Monitor; Multi-Institutional Clinical Trial; National Institute of Drug Abuse; Native Americans; Network-based; Participant; Patients; Performance; Pharmaceutical Preparations; Population; Principal Investigator; Progress Reports; Protocols documentation; Range; Recovery; Research; Research Infrastructure; Research Personnel; Research Training; Role; Sampling; San Francisco; Savings; Science; Site; Substance abuse problem; Suggestion; Supervision; Testing; Training; Training Programs; Translational Research; U-Series Cooperative Agreements; Universities; Work; Writing; base; checkup examination; concept; dissemination research; experience; improved; programs; quality assurance; research study; response; tool; treatment program

DESCRIPTION (provided by applicant): The University of California, San Francisco (UCSF), in collaboration with the University of Arizona and a contributing group of community treatment programs (CTPs), proposes to continue a cooperative agreement to lead a node in the National Drug Abuse Treatment Clinical Trials Network (CTN). Our research node consists of a Regional Research and Training Center (RRTC) at UCSF that is linked in partnership with researchers and CTPs in California and Arizona. The goal of the research node is to participate in and conduct high-quality multi-site clinical trials of interventions for drug abuse and to guide the development, dissemination, and adoption of effective interventions in the field. In the initial funding period a strong, collaborative infrastructure was established with bi-directional communication among treatment and research communities. The node demonstrated high-quality participation in seven CTN research protocols, including five multi-site clinical trials, the node obtained funding for five studies that used the CTN as a platform for research, and the node is co-leading an emerging clinical trial of HIV rapid testing and counseling. The specific aims of this proposal are to: (1) Participate in clinical trials of treatments for drug abuse. The node makes a special contribution to HIV/AIDS and co-occurring disorders, health services research, and dissemination. (2) Collaborate with the national CTN leadership in research studies, with special attention to patients with co-occurring problems. The CA-AZ Node will co-lead, with the Florida Node, a study of HIV rapid testing and counseling. It also proposes a research concept linking methamphetamine-dependent patients to treatment by using recovery management checkups. (3) Use the CTN as a research platform by conducting at least three extramurally funded studies linked to the CTN. Node personnel will also continue to seek extramural support for "platform studies." (4) Further develop the CTN as a training site by partnering with existing research training programs at UCSF and University of Arizona. We will involve at least one new trainee each year, collaborate with two Native American programs to develop research capacity, and apply for at least one minority supplement to the core grant. (5) Aid in using the CTN as a site for dissemination research by partnering with local, regional, and national activities. Closing the gap between research and treatment is one of the most critical unresolved issues in drug abuse, and the NIDA CTN can have a significant role. Based on the CA-AZ Node's experience, access to unique and hard-to-reach populations, and a knowledgeable team of investigators and CTPs, this research node has the potential to accelerate the advance of clinical trials and translational research in the coming years.

描述（由申请人提供）：加州大学旧金山分校（UCSF）与亚利桑那大学和一个社区治疗项目（ctp）贡献小组合作，提议继续合作协议，领导国家药物滥用治疗临床试验网络（CTN）的一个节点。我们的研究节点由UCSF的区域研究和培训中心（RRTC）组成，该中心与加利福尼亚州和亚利桑那州的研究人员和ctp合作。该研究节点的目标是参与并开展药物滥用干预措施的高质量多地点临床试验，并指导该领域有效干预措施的开发、传播和采用。在最初的资助阶段，建立了强大的协作基础设施，在治疗和研究界之间进行双向沟通。该节点在七项CTN研究方案中表现出高质量的参与，包括五项多地点临床试验，该节点获得了五项使用CTN作为研究平台的研究的资助，该节点正在共同领导一项新兴的艾滋病毒快速检测和咨询临床试验。本提案的具体目的是：(1)参与药物滥用治疗的临床试验。该节点对艾滋病毒/艾滋病和并发疾病、保健服务研究和传播作出了特殊贡献。(2)与国家CTN领导机构合作开展研究，特别关注有共同问题的患者。CA-AZ节点将与佛罗里达节点共同领导艾滋病毒快速检测和咨询的研究。它还提出了一个研究概念，通过使用康复管理检查将甲基苯丙胺依赖患者与治疗联系起来。(3)通过开展至少三项与CTN相关的外部资助研究，将CTN作为研究平台。Node人员还将继续寻求外部支持，进行“平台研究”。(4)通过与加州大学旧金山分校和亚利桑那大学现有的研究培训项目合作，进一步将CTN发展成为一个培训站点。我们将每年至少招收一名新学员，与两个美洲原住民项目合作发展研究能力，并申请至少一项少数族裔补助来补充核心拨款。(5)通过与地方、区域和国家活动合作，帮助利用CTN作为传播研究的场所。缩小研究和治疗之间的差距是药物滥用中最关键的未解决问题之一，NIDA CTN可以发挥重要作用。基于CA-AZ节点的经验、独特且难以接触的人群，以及知识渊博的研究人员和ctp团队，该研究节点有可能在未来几年加速临床试验和转化研究的进展。