California-Arizona Clinical Trials Network Node

加州-亚利桑那州临床试验网络节点

• 批准号: 7685340
• 负责人: James L Sorensen
• 金额: $ 124.17万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7685340
• 关键词: AIDS/HIV problem; Administrative Efficiency; Adoption; Ally; Area; Arizona; Attention; California; Cancer Center Support Grant; Clinic; Clinical Treatment; Clinical Trials; Clinical Trials Network; Collaborations; Communication; Communities; Counseling; Country; Data; Development; Disease; Drug abuse; Extramural Activities; Feedback; Florida; Funding; Future; Goals; Guidelines; HIV; Health Personnel; Health Services Research; Heart; Human Resources; Individual; Intervention; Lead; Leadership; Link; Measures; Medical; Methamphetamine; Minority; Mission; Modeling; Monitor; Multi-Institutional Clinical Trial; National Institute of Drug Abuse; Native Americans; Network-based; Participant; Patients; Performance; Pharmaceutical Preparations; Population; Principal Investigator; Progress Reports; Protocols documentation; Recovery; Research; Research Infrastructure; Research Personnel; Research Training; Role; Sampling; San Francisco; Savings; Science; Site; Substance abuse problem; Suggestion; Supervision; Testing; Training; Training Programs; Translational Research; U-Series Cooperative Agreements; Universities; Work; Writing; base; checkup examination; clinical infrastructure; community based treatment; dissemination research; effective intervention; experience; improved; patient population; programs; quality assurance; research study; response; tool; treatment program

DESCRIPTION (provided by applicant): The University of California, San Francisco (UCSF), in collaboration with the University of Arizona and a contributing group of community treatment programs (CTPs), proposes to continue a cooperative agreement to lead a node in the National Drug Abuse Treatment Clinical Trials Network (CTN). Our research node consists of a Regional Research and Training Center (RRTC) at UCSF that is linked in partnership with researchers and CTPs in California and Arizona. The goal of the research node is to participate in and conduct high-quality multi-site clinical trials of interventions for drug abuse and to guide the development, dissemination, and adoption of effective interventions in the field. In the initial funding period a strong, collaborative infrastructure was established with bi-directional communication among treatment and research communities. The node demonstrated high-quality participation in seven CTN research protocols, including five multi-site clinical trials, the node obtained funding for five studies that used the CTN as a platform for research, and the node is co-leading an emerging clinical trial of HIV rapid testing and counseling. The specific aims of this proposal are to: (1) Participate in clinical trials of treatments for drug abuse. The node makes a special contribution to HIV/AIDS and co-occurring disorders, health services research, and dissemination. (2) Collaborate with the national CTN leadership in research studies, with special attention to patients with co-occurring problems. The CA-AZ Node will co-lead, with the Florida Node, a study of HIV rapid testing and counseling. It also proposes a research concept linking methamphetamine-dependent patients to treatment by using recovery management checkups. (3) Use the CTN as a research platform by conducting at least three extramurally funded studies linked to the CTN. Node personnel will also continue to seek extramural support for "platform studies." (4) Further develop the CTN as a training site by partnering with existing research training programs at UCSF and University of Arizona. We will involve at least one new trainee each year, collaborate with two Native American programs to develop research capacity, and apply for at least one minority supplement to the core grant. (5) Aid in using the CTN as a site for dissemination research by partnering with local, regional, and national activities. Closing the gap between research and treatment is one of the most critical unresolved issues in drug abuse, and the NIDA CTN can have a significant role. Based on the CA-AZ Node's experience, access to unique and hard-to-reach populations, and a knowledgeable team of investigators and CTPs, this research node has the potential to accelerate the advance of clinical trials and translational research in the coming years.

描述（由申请人提供）：加州大学弗朗西斯科分校（UCSF）与亚利桑那大学和社区治疗计划（CTP）的贡献组合作，提议继续合作协议，以领导国家药物滥用治疗临床试验网络（CTN）的一个节点。我们的研究节点包括一个区域研究和培训中心（RRTC）在加州大学旧金山分校，这是与研究人员和CTP在加州和亚利桑那州的合作伙伴关系。该研究中心的目标是参与和开展高质量的药物滥用干预措施多地点临床试验，并指导该领域有效干预措施的制定、传播和采用。在最初的资助期间，建立了一个强大的合作基础设施，在治疗和研究社区之间进行双向沟通。该节点高质量地参与了七项CTN研究方案，包括五项多地点临床试验，该节点获得了五项使用CTN作为研究平台的研究的资金，并且该节点正在共同领导一项新兴的艾滋病毒临床试验快速检测和咨询。该提案的具体目的是：（1）参与药物滥用治疗的临床试验。该节点对艾滋病毒/艾滋病和并发疾病、卫生服务研究和传播作出了特殊贡献。(2)在研究中与国家CTN领导层合作，特别关注患有并发症的患者。CA-AZ节点将与佛罗里达节点共同领导一项艾滋病毒快速检测和咨询研究。它还提出了一个研究概念，通过使用恢复管理检查将甲基苯丙胺依赖患者与治疗联系起来。(3)使用CTN作为研究平台，进行至少三项与CTN相关的校外资助研究。节点工作人员还将继续为“平台研究”寻求校外支持。“（4）通过与加州大学旧金山分校和亚利桑那大学现有的研究培训项目合作，进一步发展CTN作为培训网站。我们将每年至少有一名新的实习生，与两个美洲原住民项目合作，以发展研究能力，并申请至少一个少数民族补充核心补助金。(5)通过与地方、区域和国家活动合作，帮助使用CTN作为传播研究的网站。缩小研究和治疗之间的差距是药物滥用方面最关键的未解决问题之一，NIDA CTN可以发挥重要作用。基于CA-AZ节点的经验，对独特和难以接触的人群的访问，以及知识渊博的研究人员和CTP团队，该研究节点有可能在未来几年加速临床试验和转化研究的进展。