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Clinical Trials Network, Ohio Valley Node

临床试验网络，俄亥俄谷节点

基本信息

批准号：
7498313
负责人：
EUGENE C. SOMOZA
金额：
$ 95万
依托单位：
UNIVERSITY OF CINCINNATI
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-09-30 至 2010-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7498313
关键词：
14 year old AIDS prevention AIDS/HIV problem Abbreviations Absorbent Pads Abstinence Accident and Emergency department Accountability Accounting Acetaldehyde Acquired Immunodeficiency Syndrome Acute Address Adhesives Administrator Adolescent Adolescent Medicine Adopted Adoption Adult Adverse drug effect Adverse effects Adverse event Advertising African African American Aftercare Age Age-Years Agreement Alaska Native Alcohol abuse Alcohol consumption Alcohol dependence Alcohol or Other Drugs use Alcoholism Alcohols Algorithms All Sites Alleles Amendment American American Indians Amphetamines Anatomy Angiography Anguish Animal Behavior Anti-Anxiety Agents Anticonvulsants Antihypertensive Agents Anxiety Appalachian Region Appendix Appointment Area Asians Attention Authorization documentation Authorship Back Baclofen Basic Science Beck depression inventory Behavior Behavior Therapy Behavioral Behavioral Sciences Bilateral Biological Biomedical Engineering Bipolar Disorder Blood Blood Chemical Analysis Blood Pressure Boston Brain Budgets Buprenorphine Bupropion Burn injury Businesses Carbamazepine Carboxylic Ester Hydrolases Cardiac Cardiovascular Diseases Cardiovascular system Caring Case Management Case Report Form Categories Caucasians Caucasoid Race Cellular biology Certification Chairperson Characteristics Cheek structure Chemicals Chest Chicago Child Cities Clinic Clinical Clinical Management Clinical Practice Guideline Clinical Research Clinical Trials Clinical Trials Data Monitoring Committees Clinical Trials Design Clinical Trials Network Cocaine Cocaine Dependence Cocaine Users Code Cognitive Cognitive Therapy Collaborations Commit Committee Members Communicable Diseases Communication Communities Community Pharmacy Community Surveys Comorbidity Complex Complication Computer Hardware Computer Systems Computer software Concept Review Condition Conduct Clinical Trials Connecticut Consensus Consent Consent Forms Consultations Contact Info Contracts Control Groups Counseling Count Country County Crack Cocaine Criminal Justice Crisis Intervention Cultural Diversity Cutaneous Cytosine DSM-IV Daily Data Data Analyses Data Collection Data Reporting Databases Day Care Death Rate Decision Making Dedications Dependence Dependency Depressed mood Detox Development Development Plans Development, Other Diagnosis Diagnostic Dictionary Diethyldithiocarbamate Diffusion Diffusion of Innovation Disadvantaged Discipline Disease Distant Disulfiram Dizziness Doctor of Medicine Doctor of Philosophy Documentation Domestic Violence Dopamine Dopamine-beta-monooxygenase Dose Double-Blind Method Drops Drowsiness Drug Addiction Drug Courts Drug Kinetics Drug Metabolic Detoxication Drug Monitoring Drug abuse Eating Disorders Economics Education Educational Status Effectiveness Effectiveness of Interventions Electrocardiogram Electrophysiology (science)Elements Eligibility Determination Employment Encapsulated Enrollment Ensure Environment Enzymes Equation Equilibrium Equipment and supply inventories Ethanol Ethnic Origin Ethnic group Euphoria Evaluation Evidence based practice Evidence based treatment Evolution Excision Exclusion Criteria Expenditure Exposure to Face Faculty Family Family member Family psychotherapy Feedback Fees Female Female Adolescents Florida Flushing Fostering Foundations Frequencies Funding Future GABA Receptor Gambling Gender Gender Issues Generations Generic Drugs Genes Genetic Genetic Polymorphism Geographic Locations Ghetto Goals Governing Board Grant Graph Gray unit of radiation dose Group Meetings Guidelines HIV HIV Infections Half-Life Hand Haplotypes Head Headache Health Health Personnel Health Services Hearing Hearing Impaired Persons Heart Heart Diseases Heart Rate Hematology Hepatic Hepatitis C Hepatotoxicity Heroin Heroin Dependence Hispanics Homelessness Horns Hour Housing Human Human Genetics Human Resources Human immunodeficiency virus test Huntington Disease Hypnotics and Sedatives Hypotension Illinois Image Immersion Investigative Technique Imprisonment Incentives Incidence Indiana Individual Information Technology Informed Consent Ingestion Inpatients Institute of Medicine (U.S.)Institution Instruction Insurance Intake Interest Group International Internet Intervention Interview Interviewer Investigation Investigational New Drug Application Iowa Jail Job Description Joints Judgment Kentucky Ketoconazole Knowledge Label Laboratories Laboratory Study Language Laws Lead Leadership Left Letters Levetiracetam Licensing Life Limes Linear Models Literature Liver Liver Function Tests Location Long Island Low income Magnetic Resonance Imaging Magnetism Mails Maintenance Maintenance Therapy Manuals Marijuana Measurement Measures Medicaid Medical Medical Staff Medical center Medication Management Medicine Mental Depression Mental Health Mentally Ill Persons Mentors Metabolism Methadone Methodology Methods Methyl Green Methylphenidate Metyrapone Mexico Minnesota Minor Minority Mission Mississippi Missouri Mixed Function Oxygenases Modafinil Modality Modeling Molecular and Cellular Biology Monitor Monitoring Clinical Trials Morphine Mothers Motivation Multi-Institutional Clinical Trial Mycoses Naloxone Naltrexone Names National Institute of Drug Abuse Native Americans Nausea Network-based Neurobiology Neurologic Neurosciences New York Nickel Nicotine Norepinephrine Numbers Object Attachment Office of Administrative Management Ohio Operative Surgical Procedures Opiate Addiction Opiates Opioid Opioid Receptor Oregon Outcome Outcome Measure Outpatients Oxygen PI protocol PTGS1 gene Pacific Island Americans Pain Pan Genus Panic Paper Paranoia Parent-Child Relations Participant Pathway interactions Patient Admission Patient Care Patient Self-Report Patient currently pregnant Patients Pediatric Hospitals Pediatrics Performance Personal Satisfaction Persons Pharmaceutical Preparations Pharmacists Pharmacologic Substance Pharmacological Treatment Pharmacology Pharmacy facility Phase Physician Executives Physicians Physiological Placebo Control Placebos Plasma Play Policies Population Positioning Attribute Poverty Pregnancy Tests Pregnant Women Prejudice Preparation Prevention Prevention education Prevention intervention Prevention program Principal Investigator Prisoner Procedures Process Productivity Progress Reports Property Protocol Compliance Protocols documentation Provider Psychiatrist Psychiatry Psychological reinforcement Psychology Psychometrics Psychotherapy Public Health Publications Published Comment Publishing Purpose Qualifying RPS19 gene Race Rain Randomized Randomized Clinical Trials Randomized Controlled Clinical Trials Randomized Controlled Trials Range Rate Reaction Readiness Reading Receptor Gene Recovery Recruitment Activity Regulatory Affairs Relapse Reporting Reproductive Health Reproductive Health Services Research Research Activity Research Design Research Ethics Committees Research Infrastructure Research Personnel Research Training Reserpine Residential Treatment Resistance Resolution Resources Review Committee Rewards Riboflavin Rights Riots Risk Risk Behaviors Risk Reduction Risk-Taking Rivers Role Role playing therapy Route Running Rural Safety Sample Size Sampling Savings Schedule Schools Science Score Screening procedure Secure Selection Criteria Selegiline Self-Administered Series Serious Adverse Event Sertraline Services Severe Adverse Event Severities Severity of illness Sexually Transmitted Diseases Shipping Ships Signal Transduction Single Nucleotide Polymorphism Site Site Visit Skin Sleeplessness Slide Smoking Software Engineering Solid Solutions Source Specific qualifier value Specificity Spectrum Analysis Staging Standards of Weights and Measures Structure Students Study Subject Substance Addiction Substance Use Disorder Substance abuse problem Supervision Surveys Sweat Sweating Syndrome System Tablets Target Populations Tattooing Techniques Technology Technology Transfer Teleconferences Telefacsimile Telephone Terminology Testing Text Therapeutic community technique Thinking Third-Party Payer Thymine Time Time Study TimeLine Tin Title Tobacco Tobacco Dependence Touch sensation Toxic effect Toxicology Trainers Training Training Trauma Treatment Protocols Treatment outcome Turtles Uca Ultraviolet Rays Unemployment United States United States Food and Drug Administration United States National Institutes of Health United States Substance Abuse and Mental Health Services Administration Universities Update Upper arm Urban Population Urinalysis Urine Variant Veterans Vigabatrin Vision Visit Voting Wages Washington Water Week West Virginia Wisconsin Woman Work World Health Organization Writing Y base Youth acamprosate addiction aged alcohol abuse therapy alcohol and other drug alcohol research base benzoylecgonine birth control blind caN protocol carboxylesterase care systems child bearing child protective service cigarette smoking clinical efficacy clinical research site clinically relevant clinically significant cocaethylene cohort college community based service compliance behavior computer monitor computerized data processing concept contingency management cost craving cyclooxygenase 1 data integrity data management database design day demographics design donepezil dosage drinking drug abuser dual diagnosis dysphoria ecgonine methyl ester ethnic minority population experience falls fighting follow-up gabapentin group counseling health care service utilization high school human subject hypnotic improved indexing innovation insight instrument interest lamotrigine male medication compliance member men men who have sex with men methadone clinic/center metropolitan motivational enhancement therapy mu opioid receptors mutant named group neurochemistry neuroimaging neutrophil offender organizational structure outreach oxcarbazepine peginterferon alfa-2b placebo controlled study pregnancy hypertension prevent probation professor programs protocol development psychosocial quality assurance research and development research study response safer sex satisfaction sex size skills smoking cessation social special interest group statistics substance abuser success symposium therapy development tiagabine tool topiramate training project transmission process treatment center treatment duration treatment program trend valproate volunteer voucher wasting willingness

项目摘要

The Ohio Valley Node (OVN) joined NIDA's Clinical Trials Network (CTN) four years ago, as one of the CTN's second wave of grantees. From the very beginning, the OVN has been a highly effective, enthusiastic, and energetic node that has excelled in providing scientific and administrative leadership, in collaborating with other nodes andwith NIDA staff, and in disseminating informationabout evidence-based practice and the results of CTN studies. Moreover, the OVN has developed a model bi-directional relationship between its University of Cincinnati-affiliated Regional Research and Training Center (RRTC) and its six original ("core") community treatment programs (CTPs), which are located in Ohio, Indiana, Kentucky, and West Virginia. In this continuation application, the OVN proposes to enhance the geographical and cultural diversity of the CTN by expanding the OVN's Midwestern and Appalachian presence in the network and adding a Mississippi Delta component, via nine additional "protocol-specific" CTPs in five additional states. The fifteen OVN CTPs, which together treat more than 52,000 patients a year, will contribute significantly to the number and variety of potential participants for CTN studies. Each of the core OVN CTPs has participated in at least one CTN clinical trial and two survey studies., and all six will continue to share in the administration of the node and in its development of research concepts and protocols. Although the new protocol-specific CTPs will play a more limited role, they are looking forward with enthusiasm to participating in appropriate clinical trials, providing an expanded and enriched patient population to the CTN. During the OVN's first four years in the CTN, we have immersed ourselves fully in all of its activities. We have submitted nine protocol concepts, of which five were chosen for further development; two have been converted into full protocols, including one which is currently enrolling participants. We have been active in the national committees of the CTN, providing five committee chairs and authoring or contributing to many SOPs and "guidance" documents. Unique contributions by the OVN include a system used CTN-wide for monitoring and reporting on staff training requirements and accomplishments, a system for tracking the progress of CTN clinical trials, and a template used to standardize the organization of CTN node budgets. The sense of satisfaction we feel in these and other accomplishments, together with the urgency we feel to continue working on the important search for effective reatments for substance abuse, make us eager to continue the work we have begun.

四年前，俄亥俄州山谷节点（OVN）加入了NIDA的临床试验网络（CTN），成为CTN的一员。第二波捐赠者。从一开始，OVN就一直是一个高效，热情和充满活力的组织。在提供科学和行政领导、与其他节点合作以及与 NIDA的工作人员，并在传播信息的循证实践和CTN的研究结果。此外，委员会认为， OVN已经在其附属于弗吉尼亚大学的区域大学之间建立了一种双向关系模型研究和培训中心（RRTC）及其六个原始（“核心”）社区治疗方案（CTP），这是位于俄亥俄州、印第安纳州、肯塔基州和西弗吉尼亚州。在这项延续申请中，OVN建议通过以下方式加强CTN的地理和文化多样性扩大OVN在中西部和阿巴拉契亚地区的网络，并增加一个密西西比三角洲组成部分，通过另外五个州的另外九个“特定于方案”的现金转拨方案。15个OVN CTP，一起治疗更多每年超过52，000名患者，将大大增加CTN潜在参与者的数量和种类问题研究每个核心OVN CTP都参与了至少一项CTN临床试验和两项调查研究。和所有六个中心将继续共同管理该节点，并共同制定研究概念和协议。虽然新的方案专用现金转拨方案将发挥更有限的作用，但他们热情地期待着参与适当的临床试验，为CTN提供扩大和丰富的患者人群。在OVN在CTN的头四年里，我们完全沉浸在它的所有活动中。我们有提交了九个协议概念，其中五个被选为进一步发展;两个已转化为完整的包括目前正在招募参与者的一项协议。我们一直积极参与国家委员会的工作， CTN提供了五个委员会主席，并编写或参与了许多SOP和“指导”文件。维也纳办事处的独特贡献包括一个在整个维也纳办事处用于监测和报告工作人员培训情况的系统要求和成就，用于跟踪CTN临床试验进展的系统，以及用于规范CTN节点预算编制。我们在这些和其他方面的满足感成就，以及我们感到继续努力寻求有效的药物滥用的治疗，使我们渴望继续我们已经开始的工作。