The role of anxiety sensitivity and smoking in adolescent panic vulnerability

焦虑敏感性和吸烟在青少年恐慌脆弱性中的作用

• 批准号: 7242204
• 负责人: ELLEN W LEEN-FELDNER
• 金额: $ 6.86万
• 依托单位: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7242204
• 关键词: Address; Adolescence; Adolescent; Adult; Age; Anxiety; Anxiety Disorders; Biological; Clinical; Cognitive; Complex; Daily; Data; Development; Emotional; Empirical Research; Esthesia; Evaluation; Growth; Health behavior; Heart Rate; Hyperventilation; Individual; Individual Differences; Intervention; Interview; Laboratories; Light; Literature; Maintenance; Mental Health; Modeling; Outcome; Panic; Panic Attack; Panic Disorder; Participant; Pathogenesis; Patient Self-Report; Persons; Population; Predisposition; Procedures; Process; Psychopathology; Public Health; Rate; Recovery; Relative (related person); Research; Risk; Risk Factors; Role; Smoke; Smoker; Smoking; Smoking Behavior; Smoking History; Staging; Structure; Symptoms; Time; Tobacco use; United States National Institutes of Health; Work; Youth; adolescent smoking; base; cigarette smoking; clinically relevant; clinically significant; depressive symptoms; indexing; innovation; intervention program; malleable risk; neglect; non-smoker; response; smoking cessation; theories; uptake

DESCRIPTION (provided by applicant): Despite the high rates of cigarette smoking among individuals with panic attacks and panic disorder, there is very little research on the association between smoking and panic-relevant processes among youth. Indeed, there is no research that has integrated smoking with the well-established panic-relevant risk factor of anxiety sensitivity (AS) in a laboratory paradigm among youth. This relative degree of neglect is unfortunate, as adolescence is a "high-risk" developmental period during which both daily smoking and panic attacks typically first occur. Accordingly, the present proposal aims to fill this gap in the empirical literature by examining whether AS moderates the relation between smoking history and fearful-responding to a voluntary hyperventilation challenge among adolescents. The proposed study is a multimethod laboratory evaluation of emotional responding to a hyperventilation challenge. Participants will be 180 psychologically healthy adolescents, evenly divided across the various stages of smoking uptake (i.e., Non-smokers, Tried Smoking, Experimenters, Regular Smokers, and Daily Smokers). The study involves the administration of a structured clinical interview, verification of tobacco use via expired CO analyses, self-report assessments, and a hyperventilation challenge procedure. It is hypothesized that persons high in AS who are at more advanced stages of smoking uptake, relative to all other variable combinations, will evidence the highest levels of panic-relevant responding to, and slowest recovery from, the hyperventilation challenge. This research is relevant to NIH objectives because a more comprehensive understanding of the relationship between cigarette smoking and panic vulnerability will provide critical information on clinically- relevant individual differences among adolescent smokers that relate to an increased susceptibility for panic disorder development and the maintenance of smoking behavior This project is has public health significance because it focuses on two inter-related malleable risk factors for psychopathology. As such, it will inform clinical intervention efforts for both panic and smoking processes among youth.

描述（由申请人提供）：尽管在惊恐发作和惊恐障碍患者中吸烟率很高，但关于吸烟与青少年惊恐相关过程之间关系的研究很少。事实上，还没有研究将吸烟与焦虑敏感性（AS）这一公认的恐慌相关风险因素结合起来，并在实验室中对年轻人进行研究。这种相对程度的忽视是不幸的，因为青春期是一个“高风险”的发展时期，在此期间，每天吸烟和恐慌发作通常首先发生。因此，本建议的目的是填补这一空白，在实证文献中，检查是否作为缓和吸烟史和恐惧之间的关系，响应青少年之间的自愿过度换气的挑战。这项研究是一个多方法的实验室评估情绪反应过度换气的挑战。参与者将是180名心理健康的青少年，平均分布在吸烟的各个阶段（即，不吸烟者，尝试吸烟者，实验者，经常吸烟者和每日吸烟者）。该研究包括管理结构化的临床访谈，通过过期CO分析验证烟草使用，自我报告评估和过度通气挑战程序。据推测，高AS的人谁是在更先进的阶段吸烟的吸收，相对于所有其他变量的组合，将证明最高水平的恐慌相关的反应，最慢的恢复，过度换气的挑战。这项研究与NIH的目标有关，因为更全面地了解吸烟与恐慌脆弱性之间的关系将提供青少年吸烟者临床相关个体差异的关键信息，这些差异与恐慌障碍发展的易感性增加和吸烟行为的维持有关。精神病理学的相关可塑性风险因素。因此，它将为青少年恐慌和吸烟过程的临床干预工作提供信息。