Cine-DENSE MRI to study right-and left ventricular forms of cardiomyopathy in SA

电影 DENSE MRI 研究 SA 中右心室和左心室形式的心肌病

• 批准号: 7236302
• 负责人: Frederick H Epstein
• 金额: $ 3.9万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-27 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7236302
• 关键词: Africa; Africa South of the Sahara; African; Algorithms; Animal Model; Area; Arrhythmogenic Right Ventricular Dysplasia; Blood flow; Cardiac; Cardiomyopathies; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Cessation of life; Collaborations; Condition; Country; Diagnosis; Dimensions; Disease; EFRAC; Environment; Etiology; Famines; Gene Transfer; Grant; Heart Diseases; Heart Transplantation; Heart failure; Hospitals; Human; Hypertension; Image; Image Analysis; Imaging Techniques; Infarction; Infection; Intervention; Invasive; Investigation; Knockout Mice; Left; Left Ventricular Dysfunction; Localized; Location; Magnetic Resonance Imaging; Measures; Mechanics; Methodology; Methods; Motion; Mus; Myocardial; Myocardial Infarction; Myocardial Ischemia; Myocardial perfusion; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Normal Range; Outcome; Parents; Patients; Pattern; Perfusion; Phase; Plague; Population; Prevalence; Process; Research; Resolution; Resources; Rheumatic Heart Disease; Right ventricular structure; Role; Signal Transduction; Slice; Societies; South Africa; Techniques; Testing; Time; Tissues; United States National Institutes of Health; Universities; Ventricular; Ventricular Dysfunction; base; disability; healthy volunteer; heart function; heart imaging; mortality; neoplastic; novel; tissue oxygenation; tool; two-dimensional

DESCRIPTION (provided by applicant): This research will be conducted primarily in South Africa at the University of Cape Town (UCT) and Groote Schuur Hospital (GSH) in Cape Town, South Africa, in collaboration with Drs Mayosi, Meintjes, and Smedema, as an extension of NIH grant #1 R01 EB001763. The overall aim is to apply cine-DENSE (Displacement Encoding with Stimulated Echos) MRI to the study of wall motion abnormalities that occur in left-and right ventricular forms of cardiomyopathy that are particularly prevalent in sub-Saharan Africa and to develop highly automated algorithms for the quantitative analysis of such images. The cardiomyopathies pose the greatest challenge of all the cardiovascular diseases in Africa because of their greater prevalence in societies still plagued by diseases of famine and pestilence; difficulty in diagnosis due to the lack of specialized cardiological investigations in resource poor environments; the lack of access to effective interventions such as heart transplantation; and the high mortality associated with these often irreversible disorders of heart muscle. Wall motion abnormality in cardiomyopathy may be the earliest functional abnormality before clinically detectable heart failure and may provide direct information about the contractile function of the heart. Previous wall motion imaging techniques suffer from either low spatial resolution or poor accuracy. Cine-DENSE achieves tracking of the myocardial motion through the cardiac cycle at pixel-wise spatial resolution with high accuracy. Slice following has recently been implemented for cine-DENSE achieving accurate 3D left ventricular (LV) motion tracking. These methodologies have not been applied to the RV and automatic segmentation of the LV and RV myocardium has not been achieved. Cine-DENSE has not been applied to the study of wall motion abnormalities that occur in cardiomyopathy and offers higher spatial resolution than techniques used in previous studies. Specifically, wall motion abnormality will be correlated with outcome at 1 year in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) and peripartum cardiomyopathy (PCM). Tools will be developed for 3D tracking of the myocardial motion of both the LV and RV by developing a more robust phase unwrapping algorithm; automatic myocardial segmentation will be achieved using a motion-based algorithm, and 3D intramyocardial strain tensors will be computed at a pixel resolution by combining Strain Encoded (SENC) and DENSE MRI.

描述（由申请人提供）：本研究将主要在南非开普敦大学（UCT）和南非开普敦的Groote Schuur医院（GSH）与Mayosi、Meintjes和Smedema博士合作进行，作为NIH资助#1 R 01 EB 001763的扩展。总体目标是将电影-密集（刺激回波位移编码）MRI应用于研究在撒哈拉以南非洲特别普遍的左心室和右心室心肌病中发生的室壁运动异常，并开发用于此类图像定量分析的高度自动化算法。心肌病是非洲所有心血管疾病中最大的挑战，因为其在仍然受到饥荒和瘟疫困扰的社会中更为普遍;由于在资源贫乏的环境中缺乏专门的心脏病学调查，诊断困难;缺乏获得心脏移植等有效干预措施的机会;以及与这些通常不可逆的心肌疾病相关的高死亡率。心肌病室壁运动异常可能是临床可检测到心力衰竭之前最早的功能异常，并可提供有关心脏收缩功能的直接信息。以前的室壁运动成像技术存在空间分辨率低或精度差的问题。Cine-DENSE以像素级空间分辨率高精度跟踪整个心动周期的心肌运动。最近已为电影-DENSE实现切片跟踪，以实现准确的3D左心室（LV）运动跟踪。这些方法尚未应用于RV，并且尚未实现LV和RV心肌的自动分割。Cine-DENSE尚未应用于心肌病中发生的室壁运动异常的研究，并且提供了比先前研究中使用的技术更高的空间分辨率。具体而言，室壁运动异常将与致瘤性右心室心肌病（ARVC）和围产期心肌病（PCM）患者1年时的结局相关。将通过开发更稳健的相位展开算法，开发用于LV和RV心肌运动的3D跟踪工具;将使用基于运动的算法实现自动心肌分割，并将通过结合应变编码（SENC）和DENSE MRI以像素分辨率计算3D心肌内应变张量。