Cine-DENSE MRI to study right-and left ventricular forms of cardiomyopathy in SA

电影 DENSE MRI 研究 SA 中右心室和左心室形式的心肌病

• 批准号: 7392257
• 负责人: Frederick H Epstein
• 金额: $ 3.25万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-27 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7392257
• 关键词: Africa; Africa South of the Sahara; African; Algorithms; Animal Model; Area; Arrhythmogenic Right Ventricular Dysplasia; Blood flow; Cardiac; Cardiomyopathies; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Cessation of life; Collaborations; Condition; Country; Diagnosis; Dimensions; Disease; EFRAC; Environment; Etiology; Famines; Gene Transfer; Grant; Heart Diseases; Heart Transplantation; Heart failure; Hospitals; Human; Hypertension; Image; Image Analysis; Imaging Techniques; Infarction; Infection; Intervention; Invasive; Investigation; Knockout Mice; Left; Left Ventricular Dysfunction; Localized; Location; Magnetic Resonance Imaging; Measures; Mechanics; Methodology; Methods; Motion; Mus; Myocardial; Myocardial Infarction; Myocardial Ischemia; Myocardial perfusion; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Normal Range; Outcome; Parents; Patients; Pattern; Perfusion; Phase; Plague; Population; Prevalence; Process; Research; Resolution; Resources; Rheumatic Heart Disease; Right ventricular structure; Role; Signal Transduction; Slice; Societies; South Africa; Techniques; Testing; Time; Tissues; United States National Institutes of Health; Universities; Ventricular; Ventricular Dysfunction; base; disability; healthy volunteer; heart function; heart imaging; mortality; neoplastic; novel; tissue oxygenation; tool; two-dimensional

This research will be conducted primarily in South Africa at the University of Cape Town (UCT) and Groote Schuur Hospital (GSH) in Cape Town, South Africa, in collaboration with Drs Mayosi, Meintjes, and Smedema, as an extension of NIH grant #1 RO1 EB 001763. The overall aim is to apply cine-DENSE (Displacement Encoding with Stimulated Echos) MR)to the study of wall motion abnormalities that occur in left-and right ventricular forms of cardiomyopathy that are particularly prevalent in sub-Saharan Africa and to develop highly automated algorithms for the quantitative analysis of such images. The cardiomyopathies pose the greatest challenge of all the cardiovascular diseases in Africa because of their greater prevalence in societies still plagued by diseases of famine and pestilence; difficulty in diagnosis due to the lack of specialized cardiological investigations in resource poor environments; the lack of accessto effective interventions such as heart transplantation; and the high mortality associated with these often irreversible disorders of heart muscle. Wall motion abnormality in cardiomyopathy may be the earliest functional abnormality before clinically detectable heart failure and may provide direct information about the contractile function of the heart. Previous wall motion imaging techniques suffer from either low spatial resolution or poor accuracy. Cine-DENSE achieves tracking of the myocardial motion through the cardiac cycle at pixel-wise spatial resolution with high accuracy. Slice following has recently been implemented for cine-DENSE achieving accurate 3D left ventricular (LV) motion tracking. These methodologies have not been applied to the RV and automatic segmentation of the LV and RV myocardium has not been achieved. Cine-DENSE has not been applied to the study of wall motion abnormalities that occur in cardiomyopathy and offers higher spatial resolution than techniques used in previous studies. Specifically, wall motion abnormality will be correlated with outcome at 1year in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) and peripartum cardiomyopathy (PCM). Tools will be developed for 3D tracking of the myocardial motion of both the LV and RV by developing a more robust phase unwrapping algorithm; automatic myocardial segmentation will be achieved using a motion-based algorithm, and 3D intramyocardial strain tensors will be computed at a pixel resolution by combining Strain Encoded (SENC) and DENSE MRI.

这项研究将主要在南非的开普敦大学和Groote Schuur进行 南非开普敦的GSH医院，与Mayosi、Meintjes和Smedema博士合作，作为一个 延长NIH资助#1 RO 1 EB 001763。总体目标是应用Cine-DENSE（位移编码， 刺激回波（MR）研究室壁运动异常，发生在左心室和右心室的形式， 在撒哈拉以南非洲特别普遍的心肌病，并开发高度自动化的算法， 这些图像的定量分析。心肌病是所有心血管疾病中最大的挑战 非洲的疾病，因为这些疾病在仍然受到饥荒和瘟疫困扰的社会中更为普遍; 由于在资源贫乏的环境中缺乏专门的心脏病学调查，诊断困难; 心脏移植等有效干预措施的可及性;以及与这些相关的高死亡率， 心脏肌肉不可逆的疾病。心肌病室壁运动异常可能是最早的功能性 在临床上可检测到心力衰竭之前的异常，并可提供有关收缩功能的直接信息 的心脏。以前的室壁运动成像技术存在空间分辨率低或精度差的问题。 Cine-DENSE以逐像素空间分辨率跟踪整个心动周期的心肌运动， 精度高。最近已对电影-DENSE实施切片跟踪，以实现准确的3D左心室 (LV)运动跟踪这些方法尚未应用于RV和LV的自动分割 RV心肌尚未实现。Cine-DENSE尚未应用于室壁运动的研究 发生在心肌病中的异常，并提供比以前使用的技术更高的空间分辨率 问题研究具体而言，室壁运动异常将与致心律失常患者1年时的结局相关。 右心室心肌病（ARVC）和围产期心肌病（PCM）。将为3D开发工具 通过开发更鲁棒的相位展开算法来跟踪LV和RV的心肌运动; 将使用基于运动的算法和3D心肌内应变实现自动心肌分割 将通过结合应变编码（SENC）和DENSE MRI以像素分辨率计算张量。