Center to Advance POC Diagnostics for Global Health

全球健康 POC 诊断推进中心

• 批准号: 7509036
• 负责人: GONZALO J. DOMINGO-VILLEGAS
• 金额: $ 41.93万
• 依托单位: PATH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7509036
• 关键词: Address; Cessation of life; Clinical; Collaborations; Communicable Diseases; Developed Countries; Developing Countries; Development; Diagnostic; Diagnostic tests; Drug Prescriptions; Drug resistance; Emerging Technologies; Engineering; Generations; Goals; Health; Healthcare; International; Laboratories; Lead; Legal; Manuals; Needs Assessment; Patients; Play; Private Sector; Procedures; Process; Public Health; Research; Research Personnel; Resources; Role; Scientist; Staging; Standards of Weights and Measures; Technology; Testing; Training; Training Programs; Underserved Population; Universities; Washington; Work; base; design; experience; improved; innovation; pandemic disease; point of care; prototype; research clinical testing

The use of appropriate point-of-care (POC) diagnostic tests can mean the difference between the right treatment or continued sickness or death: In low-resource settings (LRS), especially in developing countries, diagnostic capabilities are minimal, inadequate, or nonexistent. New and innovative POC diagnostic technologies designed specifically for LRS will have a major impact on global public health by: providing timely and appropriate patient treatment, reducing over-prescription of drugs, restraining the spread of drug resistance and raising early alerts of a potential pandemic disease. Emerging technologies in diagnostics offer the opportunity to address many of the clinical unmet needs in LRS. PATH, an international leader in the development of affordable and appropriate diagnostic tests, and its partners are proposing a Center to Advance Point-of-Care Diagnostics for Global Health (the Center). Over the course of five years, the Center will accelerate the development and deployment of POC diagnostic tests essential to LRS by: conducting laboratory- and field-based clinical evaluation of up to five selected prototype POC diagnostic tests (Core 1); identifying and selecting up to four innovative and promising technologies for potential development as POC diagnostic tests (Core 2); conducting assessments of the critical clinical needs related to POC diagnostics in relevant resource-limited settings (Core 3); offering a rigorous training program to educate technology developers and researchers, scientists, and engineers, including those from private-sector companies, on the realities of providing health care in LRS (Core 4); and lastly by coordinating activities through a strong, integrated management team and with the required institutional support (technical, facilities, administrative, financial, legal, and logistical) (Core 5). Through training and generation of manuals, tutorials, and standard operating procedures for the activities of all cores, and rigorous plans for dissemination of needs assessment and research, the Center will have an impact beyond its five-year duration. Managed by PATH, with collaboration from the University of Washington (UW) Department of Global Health as the lead on the training core, the Center will play a central role in accelerating the development and introduction of diagnostic tests for use at the POC. PATH'S unique and extensive experience in working with public- and private-sector partners at all stages of the product development, field testing, and introduction process, together with the UW's experience in training in LRS, provide the ideal support for the project's ultimate goal: to improve health among underserved populations worldwide by increasing the availability, accessibility, and affordability of essential POC diagnostic tests.

使用适当的护理点(POC)诊断测试可能意味着正确的 治疗或继续患病或死亡：在低资源环境下，特别是在发展中国家， 诊断能力微乎其微、不足或根本不存在。全新创新的PoC诊断 专门为LRS设计的技术将通过以下方式对全球公共卫生产生重大影响： 及时对症下药，减少用药过量，遏制用药蔓延 抗药性，并提高对潜在大流行疾病的早期警报。诊断学的新兴技术 提供机会来解决LRS中许多临床上未得到满足的需求。 Path是开发负担得起的适当诊断测试的国际领先者，其 合作伙伴正在提议建立一个中心，以促进全球卫生的护理点诊断(该中心)。完毕 在五年的时间里，该中心将加快POC诊断测试的开发和部署 通过以下方式对LRS至关重要：对最多五个选定的项目进行实验室和现场临床评估 原型PoC诊断测试(核心1)；识别和选择最多四个创新和有前途的 作为PoC诊断测试的潜在开发技术(核心2)；对 与相关资源受限环境中的PoC诊断相关的关键临床需求(核心3)；提供 严格的培训计划，以教育技术开发人员和研究人员、科学家和工程师， 包括来自私营部门公司的，关于在劳资关系中提供保健的现实情况(核心4)；以及 最后，通过一个强大的综合管理团队和所需的 体制支助(技术、设施、行政、财务、法律和后勤)(核心5)。穿过 为所有人员的活动培训和生成手册、教程和标准操作程序 核心，以及传播需求评估和研究的严格计划，中心将有一个 超过其五年期限的影响。 由PATH管理，与华盛顿大学(UW)全球卫生部合作 作为培训核心的牵头机构，该中心将在加快发展和 介绍用于POC的诊断测试。Path在工作方面的独特和广泛的经验 在产品开发、现场测试和引入的所有阶段的公共和私营部门合作伙伴 流程，再加上华盛顿大学在LRS培训方面的经验，为项目提供了理想的支持 最终目标：通过增加可获得性来改善世界各地服务不足人群的健康， 基本PoC诊断测试的可及性和可负担性。