Center to Advance POC Diagnostics for Global Health

全球健康 POC 诊断推进中心

• 批准号: 8296663
• 负责人: GONZALO J. DOMINGO-VILLEGAS
• 金额: $ 39.82万
• 依托单位: PATH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8296663
• 关键词: Address; Cessation of life; Clinical; Collaborations; Communicable Diseases; Developing Countries; Development; Diagnostic; Diagnostic tests; Drug Prescriptions; Drug resistance; Emerging Technologies; Engineering; Generations; Goals; Health; Healthcare; International; Laboratories; Lead; Legal; Manuals; Needs Assessment; Patients; Play; Private Sector; Procedures; Process; Public Health; Research; Research Personnel; Resources; Role; Scientist; Staging; Technology; Testing; Training; Training Programs; Underserved Population; Universities; Washington; Work; base; design; experience; global health; improved; innovation; pandemic disease; point of care; point-of-care diagnostics; product development; prototype; research clinical testing

The use of appropriate point-of-care (POC) diagnostic tests can mean the difference between the right treatment or continued sickness or death: In low-resource settings (LRS), especially in developing countries, diagnostic capabilities are minimal, inadequate, or nonexistent. New and innovative POC diagnostic technologies designed specifically for LRS will have a major impact on global public health by: providing timely and appropriate patient treatment, reducing over-prescription of drugs, restraining the spread of drug resistance and raising early alerts of a potential pandemic disease. Emerging technologies in diagnostics offer the opportunity to address many of the clinical unmet needs in LRS. PATH, an international leader in the development of affordable and appropriate diagnostic tests, and its partners are proposing a Center to Advance Point-of-Care Diagnostics for Global Health (the Center). Over the course of five years, the Center will accelerate the development and deployment of POC diagnostic tests essential to LRS by: conducting laboratory- and field-based clinical evaluation of up to five selected prototype POC diagnostic tests (Core 1); identifying and selecting up to four innovative and promising technologies for potential development as POC diagnostic tests (Core 2); conducting assessments of the critical clinical needs related to POC diagnostics in relevant resource-limited settings (Core 3); offering a rigorous training program to educate technology developers and researchers, scientists, and engineers, including those from private-sector companies, on the realities of providing health care in LRS (Core 4); and lastly by coordinating activities through a strong, integrated management team and with the required institutional support (technical, facilities, administrative, financial, legal, and logistical) (Core 5). Through training and generation of manuals, tutorials, and standard operating procedures for the activities of all cores, and rigorous plans for dissemination of needs assessment and research, the Center will have an impact beyond its five-year duration. Managed by PATH, with collaboration from the University of Washington (UW) Department of Global Health as the lead on the training core, the Center will play a central role in accelerating the development and introduction of diagnostic tests for use at the POC. PATH'S unique and extensive experience in working with public- and private-sector partners at all stages of the product development, field testing, and introduction process, together with the UW's experience in training in LRS, provide the ideal support for the project's ultimate goal: to improve health among underserved populations worldwide by increasing the availability, accessibility, and affordability of essential POC diagnostic tests.

使用适当的床旁（POC）诊断测试可能意味着正确的 治疗或持续患病或死亡：在资源匮乏的环境中，特别是在发展中国家， 诊断能力是最低限度的、不充分的或不存在的。新的和创新的POC诊断 专门为LRS设计的技术将通过以下方式对全球公共卫生产生重大影响： 及时、恰当地对患者进行治疗，减少过度用药，抑制药物扩散 抵抗力和提高潜在大流行病的早期警报。诊断中的新兴技术 提供了解决LRS中许多临床未满足需求的机会。 PATH是开发负担得起和适当的诊断测试的国际领导者， 合作伙伴正在提议建立一个全球健康高级护理点诊断中心（中心）。超过 在五年的时间里，该中心将加快POC诊断测试的开发和部署 对LRS至关重要的是：对多达五个选定的 原型POC诊断测试（核心1）;确定和选择多达四个创新和有前途的 作为POC诊断测试（核心2）的潜在开发技术; 在相关资源有限的环境中与POC诊断相关的关键临床需求（核心3）;提供 严格的培训计划，以教育技术开发人员和研究人员，科学家和工程师， 包括来自私营部门公司的报告，关于在LRS提供医疗保健的现实情况（核心4）; 最后，通过一个强有力的综合管理团队协调各项活动， 体制支助（技术、设施、行政、财务、法律的和后勤）（核心5）。通过 培训和编写手册、教程和标准作业程序，供所有人开展活动 核心，以及严格的需求评估和研究传播计划，该中心将有一个 影响超过五年。 由PATH管理，与华盛顿大学（UW）全球卫生部合作 作为培训中心的龙头，中心将在加快发展中发挥核心作用， 在POC中引入诊断测试。PATH在以下方面拥有独特而丰富的经验： 在产品开发、现场测试和引入的所有阶段，公共和私营部门合作伙伴 过程，再加上华盛顿大学在LRS培训方面的经验，为项目的 最终目标：通过增加可获得性，改善全世界得不到充分服务的人口的健康状况， 基本POC诊断测试的可及性和可负担性。