Center to Advance POC Diagnostics for Global Health

全球健康 POC 诊断推进中心

• 批准号: 8107651
• 负责人: GONZALO J. DOMINGO-VILLEGAS
• 金额: $ 38万
• 依托单位: PATH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8107651
• 关键词: Address; Cessation of life; Clinical; Collaborations; Communicable Diseases; Developing Countries; Development; Diagnostic; Diagnostic tests; Drug Prescriptions; Drug resistance; Emerging Technologies; Engineering; Generations; Goals; Health; Healthcare; International; Laboratories; Lead; Legal; Manuals; Needs Assessment; Patients; Play; Private Sector; Procedures; Process; Public Health; Research; Research Personnel; Resources; Role; Scientist; Staging; Technology; Testing; Training; Training Programs; Underserved Population; Universities; Washington; Work; base; design; experience; global health; improved; innovation; pandemic disease; point of care; point-of-care diagnostics; product development; prototype; research clinical testing

The use of appropriate point-of-care (POC) diagnostic tests can mean the difference between the right treatment or continued sickness or death: In low-resource settings (LRS), especially in developing countries, diagnostic capabilities are minimal, inadequate, or nonexistent. New and innovative POC diagnostic technologies designed specifically for LRS will have a major impact on global public health by: providing timely and appropriate patient treatment, reducing over-prescription of drugs, restraining the spread of drug resistance and raising early alerts of a potential pandemic disease. Emerging technologies in diagnostics offer the opportunity to address many of the clinical unmet needs in LRS. PATH, an international leader in the development of affordable and appropriate diagnostic tests, and its partners are proposing a Center to Advance Point-of-Care Diagnostics for Global Health (the Center). Over the course of five years, the Center will accelerate the development and deployment of POC diagnostic tests essential to LRS by: conducting laboratory- and field-based clinical evaluation of up to five selected prototype POC diagnostic tests (Core 1); identifying and selecting up to four innovative and promising technologies for potential development as POC diagnostic tests (Core 2); conducting assessments of the critical clinical needs related to POC diagnostics in relevant resource-limited settings (Core 3); offering a rigorous training program to educate technology developers and researchers, scientists, and engineers, including those from private-sector companies, on the realities of providing health care in LRS (Core 4); and lastly by coordinating activities through a strong, integrated management team and with the required institutional support (technical, facilities, administrative, financial, legal, and logistical) (Core 5). Through training and generation of manuals, tutorials, and standard operating procedures for the activities of all cores, and rigorous plans for dissemination of needs assessment and research, the Center will have an impact beyond its five-year duration. Managed by PATH, with collaboration from the University of Washington (UW) Department of Global Health as the lead on the training core, the Center will play a central role in accelerating the development and introduction of diagnostic tests for use at the POC. PATH'S unique and extensive experience in working with public- and private-sector partners at all stages of the product development, field testing, and introduction process, together with the UW's experience in training in LRS, provide the ideal support for the project's ultimate goal: to improve health among underserved populations worldwide by increasing the availability, accessibility, and affordability of essential POC diagnostic tests.

使用适当的即时诊断测试（POC）可能意味着正确的