从邻里到神经元及其他-猫眼课题宝

从邻里到神经元及其他

批准号：

7431475

负责人：

KRISTEN C. JACOBSON

金额：

$230.25万

依托单位：

UNIVERSITY OF CHICAGO

依托单位国家：

美国

项目类别：

财政年份：

2007

资助国家：

美国

项目状态：

已结题

起止时间：

2007-09-30 至 2012-08-31

来源：

https://reporter.nih.gov/project-details/7431475

关键词：

Academic achievement Academy Accounting Address Adolescence Adolescent Adolescent Behavior Adolescent Development Adult Affective African American Age Age of Onset Age-Years Aggressive behavior Agreement Alcohol or Other Drugs use Alcohols Alleles American Amygdaloid structure Analysis of Variance Animal Model Annual Reports Anterior Anxiety Applications Grants Archives Area Arizona Arousal Attention deficit hyperactivity disorder Award Back Behavior Behavior Control Behavior Disorders Behavior assessment Behavior monitoring Behavioral Behavioral Genetics Belief Biochemistry Bioinformatics Biologic Characteristic Biological Biological Factors Biological Psychiatry Biology Birth Blinking Blood Body mass index Brain Brain imaging Brain region Budgets CRH gene California Caregivers Caring Caucasians Caucasoid Race Cell Nucleus Cellular biology Censuses Cerebral cortex Characteristics Chicago Child Child Behavior Child Development Child Rearing Childhood Chromatin Class Clinical Clinical Trials Cognition Cognitive Cognitive Science Collaborations Collection Communities Complex Computer information processing Computers Condition Conduct Disorder Consent Consultations Corticotropin-Releasing Hormone Creativeness Crime Criminology DNA DNA Methylation DNA Sequence DNA copy number Data Data Analyses Data Collection Databases Depth Development Disadvantaged Discipline Disease Disease regression Disruption Distal District of Columbia Dizygotic Twins Doctor of Philosophy Ecology Economics Educational process of instructing Educational workshop Elderly Elements Emotional Emotions Ensure Environment Environmental Exposure Environmental Risk Factor Epigenetic Process Equation Ethnic group Experimental Psychology Exposure to Face Failure Family Family Characteristics Family Process Family Study Farming environment Female Force of Gravity Foundations Frequencies Functional Magnetic Resonance Imaging Functional disorder Funding Future Gender Gene Expression Gene Targeting Genes Genetic Genetic Models Genetic Predisposition to Disease Genetic Research Genetic Structures Genetic Variation Genome Genomics Genotype Glucocorticoid Receptor Grant Growth Hand Head Health Health Services Accessibility Heritability Heterogeneity Hippocampus (Brain)Hispanics Home environment Hour Household Human Human Development Human Genetics Hypothalamic structure Image Imaging Techniques Immunoprecipitation Impulsivity Individual Individual Differences Infant Informed Consent Intervention Interview Investigation Iowa Joints Journals Knowledge Laboratories Late Effects Laws Lead Life Life Cycle Stages Linear Models Link Longevity Longitudinal Studies Los Angeles Low income Magnetic Resonance Imaging Mammalian Genetics Maps Maternal Behavior Measurement Measures Medial Mediating Mediation Medicine Mental Depression Mental disorders Mentored Research Scientist Development Award Messenger RNA Metals Methodology Methods Methylation Michigan Minority Minority Groups Modeling Modification Molecular Molecular Genetics Molecular Profiling Monitor Monozygotic Twinning Monozygotic twins Mothers National Institute of Mental Health Nature Neighborhoods Neuraxis Neuro-Oncological Ventral Antigen 2 Neurobiology Neurons Neuropsychology Neurosciences Neurosciences Research New York Nicotine Nicotine Dependence Nucleotides Numbers Object Attachment Outcome Paper Parent-Child Relations Parental Consent Parenting behavior Parents Participant Pathway interactions Patient Self-Report Pattern Pediatrics Peer Group Peer Review Perception Personal Satisfaction Personality Persons Pharmacology Phase Phase I Clinical Trials Phase II Clinical Trials Phase III Clinical Trials Phenotype Pilot Projects Pituitary-Adrenal System Play Population Population Heterogeneity Positioning Attribute Positron-Emission Tomography Poverty Prefrontal Cortex Prevalence Prevention program Preventive Medicine Problem behavior Process Prohibit Promoter Regions Psychiatrist Psychiatry Psychologist Psychology Psychopathology Psychophysiology Psychosocial Factor Publications Published Comment Publishing Purpose Qualifying Race Range Rate Rattus Receptor Gene Recording of previous events Recruitment Activity Regulation Relative (related person)Reporting Research Research Design Research Ethics Committees Research Personnel Research Project Grants Resources Rewards Risk Risk Factors Role Rosa Route Rural SAS Sales Sampling Scanning Schools Science Seeds Seminal Series Sex Characteristics Siblings Single Parent Site Social Change Social Class Social Controls Social Disorganizations Social Environment Social Psychology Social Sciences Social isolation Socioeconomic Status Sociology Source Staging Standards of Weights and Measures Statistical Methods Stimulus Stress Stressful Event Structure Students Substance Use Disorder Supervision Surveys System Techniques Testing Thinking Time TimeLine Tobacco Training Translating Twin Multiple Birth Twin Studies United States National Institutes of Health Universities Update Variant Vietnam Violence Visit Week Work Writing Youth adolescent smoking adolescent substance use age effect age related analytical method anti social base biological research bisulfite brain research career cingulate cortex clinically significant cohort computerized data processing contextual factors cost cost effective data integration data quality day density deprivation design detector deviant early onset emotion regulation emotional stimulus endophenotype environmental stressor essays ethnic minority population experience falls father role follow-up frontal lobe genetic analysis genetic association genetic risk factor genetic variant health disparity high school human subject infancy innovation interdisciplinary approach interest life course persistent low socioeconomic status male middle age migration model design mortality multidisciplinary neural circuit nonhuman primate novel parental monitoring peer peer influence professor programs promoter protective effect psychobiologic psychogenetics psychologic psychosocial racial and ethnic racial and ethnic disparities racial difference racial discrimination racial/ethnic difference research study resilience response sex social social attachment social cognitive theory socioeconomics software development stem symposium teacher theories tool trait trend underage drinking willingness young adult

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英文摘要

The purpose of this three-phase study is to conduct a multidisciplinary-based investigation of the effects of individual, family, peer, and neighborhood characteristics on individual differences in adolescent problem behavior. Phase I consists of an in-school assessment of approximately 7,000 6th – 8th graders in 10 socioeconomically and racially and ethnically diverse schools in the Chicago Public School system. The purpose of Phase I is to obtain data on environmental and psychosocial factors that may account for socioeconomic and racial and ethnic differences in problem behavior. Phase II consists of a target sample of 400 full-, half- and unrelated sibling pairs drawn from the original Phase I study who, along with their primary caregivers, will be brought to the University of Chicago for detailed neuroscience and behavioral assessments. The primary purpose of Phase II is to identify the environmental, biological, and psychosocial variables that account for individual differences in problem behavior, and to further determine whether these effects are genetically or environmentally mediated. Phase III consists of an fMRI investigation using a target sample of 60 concordant and 40 extreme discordant sibling pairs drawn from the Phase II study. The primary purpose of Phase III is to identify the neurobiological substrates that account for within-pair differences in behavior, and to determine the extent to which nonshared environmental factors account for individual differences in neurobiological functioning. A small pilot study of 20 extremely discordant sibling pairs from Phase III will investigate whether environments alter gene expression via changes in DNA methylation. Because this nested design uses a bioecological framework to measure risk and protective factors at multiple levels of analysis- “from neighborhoods to neurons and beyond”- the resulting data uniquely allows for the investigation of mediating and moderating effects among environmental, psychosocial, biological, and genetic factors on individual differences in problem behavior.

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