SEARCH for Diabetes in Youth 2: California Center

搜索青少年糖尿病 2：加州中心

• 批准号: 7260539
• 负责人: Jean Marie Lawrence
• 金额: $ 60.49万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7260539
• 关键词: SEARCH; Diabetes; Youth; California; Center

This proposal from the California Center builds upon a five year research project, SEARCH for Diabetes in Youth, its standardized data collection effort, experienced investigator team, established case ascertainment infrastructure, and ethnically diverse population base. This is a common, integrated application from the six SEARCH clinical centers, which proposes to continue and expand the work performed by SEARCH in order to address the following specific research aims: AIM 1: Prospectively ascertain newly diagnosed (2006- 2009) incident cases age less than 20 years in order to estimate temporal trends in incidence of diabetes mellitus in youth; AIM 2: Conduct longitudinal follow-up of incident cases already recruited to SEARCH in 2002-2005 in order to document the evolution of newly diagnosed diabetes according to clinical and biochemical factors; AIM 3: Complete analyses initiated in the first five years of SEARCH and expand the scope of quality of care assessment to encompass more broadly defined concepts and measures of quality; AIM 4: Develop and validate simple and low-cost case definitions and classifications of diabetes types in youth that can be used for public health surveillance. The novelty of this proposal includes its comprehensive nature that brings together major and timely facets of childhood diabetes research: an epidemiologic study, unique in the United States, of temporal trends in the incidence of diabetes in youth; a pathophysiologic component addressing the natural history of diabetes in youth; a study of processes of care and quality of life; and a public health perspective on case classification of diabetes in youth. The strengths of the California Center are its large, diverse population; that most youth with diabetes receive health care from 1 of the 8 pediatric endocrinologists in the region; and the availability of a vast amount of electronic health data. Of the more than 770,000 youth less than 20 years, over half are Hispanic, African American, or Asian/Pacific Islander,which is representative of southern California. This research is critically important to public health. It will provide information about whether and how much diabetes incidence in the United States is increasing among youth of different backgrounds and how diabetes affects physical health, including complications, as well as data on the quality of care and the quality of life of youth with diabetes.

这项来自加州中心的建议建立在一个为期五年的研究项目之上， 青年，其标准化的数据收集工作，经验丰富的调查员团队，建立了病例确定 基础设施和种族多样化人口基础。这是一个常见的，集成的应用程序， 临床中心，建议继续和扩大临床中心的工作， 解决以下具体的研究目标：目的1：确定新诊断的前列腺癌（2006年- 2009年），以估计糖尿病发病率的时间趋势 目的2：对已经招募到社区的偶发病例进行纵向随访 2002年至2005年，根据临床和 目标3：完成在研究的前五年开始的分析，并扩大研究的范围。 护理质量评估的范围，以涵盖更广泛定义的概念和质量措施; 目的4：开发和验证简单和低成本的病例定义和糖尿病类型的分类， 可以用于公共卫生监测的年轻人。该提案的新奇包括其全面的 自然，汇集了儿童糖尿病研究的主要和及时的方面：一项流行病学研究， 在美国，年轻人糖尿病发病率的时间趋势是独一无二的; 解决青年糖尿病自然史的组成部分;护理过程和质量的研究 生活;以及从公共卫生角度对青年糖尿病病例分类。 加州中心的优势在于其庞大而多样化的人口，大多数糖尿病青年都接受了 该地区8名儿科内分泌学家中有1名提供医疗保健; 电子健康数据。在超过770，000名20岁以下的年轻人中，一半以上是西班牙裔、非洲裔 美国人，或亚洲/太平洋岛民，这是南加州的代表。这项研究是至关重要的 对公众健康很重要。它将提供有关该地区是否有糖尿病发病率以及发病率如何的信息 在美国，不同背景的年轻人越来越多，糖尿病如何影响身体健康， 包括并发症，以及关于护理质量和青年糖尿病患者生活质量的数据。