SEARCH for Diabetes in Youth, Phase 3: Cohort Study - California Center

青少年糖尿病搜索，第 3 阶段：队列研究 - 加州中心

• 批准号: 8728767
• 负责人: Jean Marie Lawrence
• 金额: $ 61.86万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8728767
• 关键词: SEARCH; Diabetes; Youth; Phase; Cohort

Project Summary SEARCH for Diabetes in Youth (SEARCH) is an on-going, multi-center study containing the largest and most ethnically diverse population of youth with diabetes ever studied in the US. In response to RFA-DP10-001, Component B, the SEARCH Cohort Study will utilize this unique resource by continuing the study of selected SEARCH participants to address the following research Aims: 1) assess the prevalence, incidence, and risk factors for selected markers of chronic microvascular (retinopathy, nephropathy, and autonomic neuropathy) and macrovascular complications (hypertension, arterial stiffness) of diabetes; 2) assess the incidence and risk factors for acute complications of diabetes including serious hypoglycemia and diabetic ketoacidosis ; 3) conduct surveillance of mortality; and 4) determine the degree to which barriers of care, quality of care, and transition to adult care impact diabetes-related health outcomes including quality of life. Overlaid across these Aims, we will focus on the impact of race/ethnicity and other sociocultural factors, and biochemical dimensions of diabetes type, on diabetes-related health outcomes. The SEARCH Cohort Study will conduct an in-person research study visit on SEARCH participants incident in 2002 or later, with duration of diabetes > 5 years and with baseline data completed (expected n=3699). During this study medical history, anthropometric, biochemical, physiologic, and survey data will be collected and analyzed. The SEARCH California Center is located within Kaiser Permanente's Department of Research and Evaluation in Pasadena California. Youth from the California SEARCH Center that will be included in this Cohort Study (n=424) are very racially/ethnically diverse and include 118 non-Hispanic White youth (110 with type 1 diabetes and 8 with type 2 diabetes) and 306 minority youth (209 with type 1 diabetes and 97 with type 2 diabetes). Half of all youth seen by this SEARCH center are Hispanic, the majority of which are Mexican American; while about 15% are African American and 5% are Asian/Pacific Islander. This study will exploit the size and ethnic diversity of the study population to identify differences in both processes of care and health outcomes by traditional, clinical diabetes type; by the major race/ethnic groups in the US; and by employing a novel approach to segregate traditional clinical diabetes types by pathophysiologic dimensions. Thus, the SEARCH cohort study has a high likelihood of making a significant impact on the clinical care of youth with diabetes from all the major ethnic groups in the US and on national public health policy.

项目摘要 青少年糖尿病研究是一项正在进行的多中心研究， 种族多样的青年糖尿病患者的研究。根据RFA-DP 10 -001， 组成部分B，即队列研究将利用这一独特资源，继续研究选定的 研究目的：1）评估患病率、发病率和风险 慢性微血管（视网膜病变、肾病和自主神经病变）选定标志物的因素 和糖尿病大血管并发症（高血压，动脉硬化）; 2）评估发病率和风险 糖尿病急性并发症的因素，包括严重低血糖和糖尿病酮症酸中毒; 3） 对死亡率进行监测; 4）确定护理障碍、护理质量和 过渡到成人护理影响糖尿病相关的健康结果，包括生活质量。覆盖在这些 目的，我们将重点关注种族/民族和其他社会文化因素的影响，以及生物化学方面 糖尿病类型，糖尿病相关的健康结果。该队列研究将进行一项面对面的 对2002年或之后发生的糖尿病事件的研究性访视，糖尿病持续时间> 5年， 完成基线数据（预期n=3699）。在本研究期间，病史、人体测量、 将收集和分析生化、生理和调查数据。美国加州中心是 位于加州帕萨迪纳的凯撒医疗机构的研究和评估部门。青年 来自加州医疗中心的患者（n=424）非常 包括118名非西班牙裔白色青年（110名1型糖尿病患者和8名1型糖尿病患者）， 2型糖尿病）和306名少数民族青年（209名1型糖尿病患者和97名2型糖尿病患者）。一半的年轻人 这个研究中心看到的是西班牙裔，其中大多数是墨西哥裔美国人;而大约15%是 非裔美国人和5%是亚洲/太平洋岛民。这项研究将利用的规模和种族多样性， 研究人群，以确定传统的，临床的， 糖尿病类型;美国的主要种族/种族群体;以及采用一种新的方法来隔离 传统的临床糖尿病类型的病理生理尺寸。因此，这项队列研究具有很高的 对来自所有主要种族的青年糖尿病患者的临床护理产生重大影响的可能性 在美国和国家公共卫生政策。