SEARCH for Diabetes in Youth, Phase 3: Cohort Study - California Center

青少年糖尿病搜索，第 3 阶段：队列研究 - 加州中心

• 批准号: 8146886
• 负责人: Jean Marie Lawrence
• 金额: $ 62.73万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8146886
• 关键词: SEARCH; Diabetes; Youth; Phase; Cohort

DESCRIPTION (provided by applicant): SEARCH for Diabetes in Youth (SEARCH) is an on-going, multi-center study containing the largest and most ethnically diverse population of youth with diabetes ever studied in the US. In response to RFA-DP10-001, Component B, the SEARCH Cohort Study will utilize this unique resource by continuing the study of selected SEARCH participants to address the following research Aims: 1) assess the prevalence, incidence, and risk factors for selected markers of chronic microvascular (retinopathy, nephropathy, and autonomic neuropathy) and macrovascular complications (hypertension, arterial stiffness) of diabetes; 2) assess the incidence and risk factors for acute complications of diabetes including serious hypoglycemia and diabetic ketoacidosis ; 3) conduct surveillance of mortality; and 4) determine the degree to which barriers of care, quality of care, and transition to adult care impact diabetes-related health outcomes including quality of life. Overlaid across these Aims, we will focus on the impact of race/ethnicity and other sociocultural factors, and biochemical dimensions of diabetes type, on diabetes-related health outcomes. The SEARCH Cohort Study will conduct an in-person research study visit on SEARCH participants incident in 2002 or later, with duration of diabetes > 5 years and with baseline data completed (expected n=3699). During this study medical history, anthropometric, biochemical, physiologic, and survey data will be collected and analyzed. The SEARCH California Center is located within Kaiser Permanente's Department of Research and Evaluation in Pasadena California. Youth from the California SEARCH Center that will be included in this Cohort Study (n=424) are very racially/ethnically diverse and include 118 non-Hispanic White youth (110 with type 1 diabetes and 8 with type 2 diabetes) and 306 minority youth (209 with type 1 diabetes and 97 with type 2 diabetes). Half of all youth seen by this SEARCH center are Hispanic, the majority of which are Mexican American; while about 15% are African American and 5% are Asian/Pacific Islander. This study will exploit the size and ethnic diversity of the study population to identify differences in both processes of care and health outcomes by traditional, clinical diabetes type; by the major race/ethnic groups in the US; and by employing a novel approach to segregate traditional clinical diabetes types by pathophysiologic dimensions. Thus, the SEARCH cohort study has a high likelihood of making a significant impact on the clinical care of youth with diabetes from all the major ethnic groups in the US and on national public health policy.

描述(由申请者提供)：搜索青年糖尿病(SEARCH)是一项正在进行的多中心研究，包含了美国有史以来研究过的最大规模和最具种族多样性的青年糖尿病人群。针对RFA-DP10-001，B组分，搜索队列研究将利用这一独特的资源，继续对选定的搜索参与者进行研究，以解决以下研究目标：1)评估糖尿病的慢性微血管(视网膜病变、肾病和自主神经病变)和大血管并发症(高血压、动脉僵硬)的选定标记物的患病率、发病率和危险因素；2)评估糖尿病急性并发症的发生率和危险因素，包括严重低血糖和糖尿病酮症酸中毒；3)进行死亡率监测；以及4)确定护理障碍、护理质量和过渡到成人护理对糖尿病相关健康结果(包括生活质量)的影响程度。在这些目标的基础上，我们将重点关注种族/民族和其他社会文化因素，以及糖尿病类型的生物化学维度对糖尿病相关健康结果的影响。搜索队列研究将对2002年或以后的搜索参与者进行面对面的研究访问，访问时间为5年，并完成基线数据(预计n=3699)。在这项研究中，将收集和分析医学史、人体测量学、生化、生理学和调查数据。搜索加州中心位于加州帕萨迪纳凯撒永久研究和评估部内。来自加州搜索中心的青年将被纳入这项队列研究(n=424)，他们的种族/族裔非常多样化，包括118名非西班牙裔白人青年(110名患有1型糖尿病，8名患有2型糖尿病)和306名少数族裔青年(209名患有1型糖尿病，97名患有2型糖尿病)。这个搜索中心发现的所有年轻人中有一半是西班牙裔，其中大部分是墨西哥裔美国人；大约15%的人是非洲裔美国人，5%的人是亚洲/太平洋岛民。这项研究将利用研究人群的规模和种族多样性，根据传统的临床糖尿病类型、美国的主要种族/民族以及采用一种新的方法按病理生理维度区分传统的临床糖尿病类型，来确定护理过程和健康结果的差异。因此，SEARCH队列研究很有可能对美国所有主要种族的青少年糖尿病患者的临床护理和国家公共卫生政策产生重大影响。