Core--Chemical process development

核心--化学工艺开发

• 批准号: 7479158
• 负责人: WEI ZHANG
• 金额: $ 29.94万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7479158
• 关键词: Antioxidants; Chemicals; Chemistry; Development; EUK-134; Grant; Health Services Research; Housing; Human Resources; Hydrogenation; Label; Laboratory Research; Lead; Libraries; Link; Methods; Molecular Probes; Organic Chemistry; Outsourcing; Peptides; Pharmaceutical Preparations; Preparation; Process; Production; Range; Research; Route; Services; Side; Staging; Standards of Weights and Measures; Technology; Work; analog; base; design; drug quality; ethyl pyruvate; inhibitor/antagonist; milligram; pressure; scale up; small molecule

This Core will reside within the labs and offices of Fluorous Technologies, Inc. (FTI), a Pittsburgh-based chemical technology company specializing in synthetic organic chemistry. FTI personnel working on the grant will provide chemistry support services on all five Projects, ranging from production of early-stage chemical discovery libraries at milligram scale to later-stage scale-up of promising lead compounds at gram scale. The Core will also provide general guidance and design input from a chemistry perspective to each of the Projects and Cores as appropriate. There are two main contributions from the Core to the grant: service and research. On the service side, the Core will synthesize in house gram quantities of existing drug candidates, molecular probes and other small molecules needed for laboratory research on all five projects, and will oversee the outsourcing of any synthesis that goes outside of FTI either for reasons of scale or specialized chemistry.

该核心将位于Fluorous Technologies，Inc.的实验室和办公室内。(FTI)，一家总部位于汉堡的化学技术公司，专门从事合成有机化学。FTI工作人员将为所有五个项目提供化学支持服务， 范围从毫克级的早期化学发现库的生产到克级的有前景的先导化合物的后期放大。核心还将酌情从化学角度为每个项目和核心提供一般指导和设计输入。核心基金对补助金的主要贡献有两项：服务和研究。在服务方面，核心将在内部合成所有五个项目实验室研究所需的现有候选药物，分子探针和其他小分子，并将监督FTI之外的任何合成的外包，无论是出于规模还是专业化学的原因。