Core--Chemical process development

这个核心将驻留在氟技术公司(FTI)的实验室和办公室内，该公司是一家总部设在匹兹堡的化学技术公司，专门从事合成有机化学。参与拨款的FTI人员将为所有五个项目提供化学支持服务， 从毫克规模的早期化学发现库的生产到克级规模的有希望的先导化合物的后期放大。核心还将酌情从化学角度为每个项目和核心提供一般指导和设计投入。核心基金有两项主要贡献：服务和研究。在服务方面，核心将在内部合成克数量的现有候选药物、分子探测器和所有五个项目的实验室研究所需的其他小分子，并将监督由于规模或专业化学原因而在快速道外进行的任何合成。

This Core will reside within the labs and offices of Fluorous Technologies, Inc. (FTI), a Pittsburgh-based chemical technology company specializing in synthetic organic chemistry. FTI personnel working on the grant will provide chemistry support services on all five Projects, ranging from production of early-stage chemical discovery libraries at milligram scale to later-stage scale-up of promising lead compounds at gram scale. The Core will also provide general guidance and design input from a chemistry perspective to each of the Projects and Cores as appropriate. There are two main contributions from the Core to the grant: service and research. On the service side, the Core will synthesize in house gram quantities of existing drug candidates, molecular probes and other small molecules needed for laboratory research on all five projects, and will oversee the outsourcing of any synthesis that goes outside of FTI either for reasons of scale or specialized chemistry.