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Solution Phase Libraries by Fluorous Mixture Synthesis

含氟混合物合成溶液相库

基本信息

批准号：
6485131
负责人：
WEI ZHANG
金额：
$ 96.02万
依托单位：
FLUOROUS TECHNOLOGIES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-04-10 至 2004-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6485131
关键词：
alkaloids chemical registry /resource chemical synthesis combinatorial chemistry drug discovery /isolation fluorine high performance liquid chromatography quinoline

项目摘要

The goal of the Phase II SBIR is to conduct research and development that will allow Fluorous Technologies, Inc. to ramp up from current analytical/demonstration libraries to the actual production of libraries of a size and scale that will be attractive to pharmaceutical and biotechnology companies. Once this capability is in place, FTI intends to be a highly competitive player in the outsourcing market for combinatorial library synthesis. This market is currently estimated at $145 million for 2000, with an annual growth rate of 15%. In addition, the technology will also be commercialized for external use. Building on successful Phase I work, the grant proposes the synthesis of 4,800-9,600 member library of mappicine analogs on 2-3 mg scale using the company's innovative new "fluorous mixture synthesis" platform. The work is divided into the "preparation phase", where all the needed starting materials, fluorous tags, and diversity reactants will be prepared, and the "production phase", where the library will be produced, purified and analyzed. PROPOSED COMMERCIAL APPLICATION: The research will validate FTI's fluorous mixture synthesis techniques in a real world setting. The company plans to use the techniques in- house for contract library synthesis and to make them available to the community at large.

第二阶段 SBIR 的目标是进行研究和开发，使 Fluorous Technologies, Inc. 能够从当前的分析/演示文库升级到实际生产的文库，其规模和规模对制药和生物技术公司有吸引力。一旦具备这种能力，FTI 打算成为组合文库合成外包市场中极具竞争力的参与者。目前估计2000年该市场规模为1.45亿美元，年增长率为15%。此外，该技术还将商业化供外部使用。在第一阶段工作成功的基础上，该赠款提议使用该公司创新的新型“含氟混合物合成”平台合成 2-3 毫克规模的 4,800-9,600 个马匹碱类似物成员库。该工作分为“准备阶段”和“生产阶段”，其中将准备所有所需的起始材料、氟标签和多样性反应物，以及“生产阶段”，其中将产生、纯化和分析文库。拟议的商业应用：该研究将在现实环境中验证 FTI 的氟混合物合成技术。该公司计划使用内部技术进行合同库合成，并将其提供给整个社区。