Core--Chemical process development

该核心将位于Fluorous Technologies，Inc.的实验室和办公室内。(FTI)，一家总部位于汉堡的化学技术公司，专门从事合成有机化学。FTI工作人员将为所有五个项目提供化学支持服务， 范围从毫克级的早期化学发现库的生产到克级的有前景的先导化合物的后期放大。核心还将酌情从化学角度为每个项目和核心提供一般指导和设计输入。核心基金对赠款的贡献主要有两个：服务和研究。在服务方面，核心将在内部合成所有五个项目实验室研究所需的现有候选药物，分子探针和其他小分子，并将监督FTI之外的任何合成的外包，无论是出于规模还是专业化学的原因。

This Core will reside within the labs and offices of Fluorous Technologies, Inc. (FTI), a Pittsburgh-based chemical technology company specializing in synthetic organic chemistry. FTI personnel working on the grant will provide chemistry support services on all five Projects, ranging from production of early-stage chemical discovery libraries at milligram scale to later-stage scale-up of promising lead compounds at gram scale. The Core will also provide general guidance and design input from a chemistry perspective to each of the Projects and Cores as appropriate. There are two main contributions from the Core to the grant: service and research. On the service side, the Core will synthesize in house gram quantities of existing drug candidates, molecular probes and other small molecules needed for laboratory research on all five projects, and will oversee the outsourcing of any synthesis that goes outside of FTI either for reasons of scale or specialized chemistry.