Nutritional Status In HIV Hispanic Drug Abusers

艾滋病毒西班牙裔吸毒者的营养状况

• 批准号: 7341381
• 负责人: JANET E FORRESTER
• 金额: $ 67.2万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7341381
• 关键词: Acute; Address; African American; Alcohol consumption; Alcohols; Animals; Antioxidants; Caucasians; Caucasoid Race; Chronic Disease; Cocaine; Cocaine Abuse; Cocaine Users; Cohort Studies; Complication; Consumption; Data; Dose; Drug abuse; Drug usage; F2-Isoprostanes; Frequencies; Goals; HIV; HIV Infections; HIV Seropositivity; Health; Hepatic Tissue; Hepatitis C; Hepatitis C virus; Hepatotoxicity; Heroin; Heroin Users; Hispanics; Infection; Intervention; Lead; Liver Dysfunction; Liver diseases; Malondialdehyde; Measures; Micronutrients; Morbidity - disease rate; National Institute of Drug Abuse; Necrosis; Nutritional status; Outcome; Oxidative Stress; Oxidative Stress Induction; Patients; Persons; Plasma; Race; Reporting; Research; Research Infrastructure; Risk; Risk Factors; Serum; Stress; Thinking; Tissues; Urine; Vitamins; cohort; drug abuser; improved; interest; liver function; mortality; prospective; trend

DESCRIPTION (provided by applicant): The BIENESTAR study is a longitudinal cohort study of the effect of drug abuse on nutritional status and outcomes among Hispanics with HIV infection. The cohort is comprised of 3 groups: HIV+ drug abusers, HIV- drug abusers, and HIV+ non-drug abusers. Efforts will focus on expanding and maintaining this unique cohort. New hypotheses addressed in this competitive renewal reflect current trends, as HIV becomes a chronic disease. Liver disease is an increasingly common complication in patients with HIV. While it is generally accepted that HCV is largely responsible for liver disease in HIV infection, studies suggest that drug abuse itself is a risk factor for liver disease among persons with HCV. Animal studies have shown that cocaine can cause liver toxicity by the induction of oxidative stress with tissue damage. Hispanics of the NE USA preferentially inject cocaine more than other races, and therefore may be at increased risk of oxidative stress and liver dysfunction. Low serum antioxidant micronutrient levels are common in drug abusers, further increasing the risk of oxidative tissue damage. This study proposes to examine antioxidant status, oxidative stress, and liver dysfunction in Hispanic drug abusers with HIV infection. There are 4 specific aims: 1) To examine the association between the type (cocaine versus heroin) and frequency of drug abuse with plasma antioxidant capacity and oxidative stress. The specific interest is to know if cocaine differs from heroin in its ability to alter antioxidant capacity and cause oxidative stress; 2) To examine the association between the type and frequency of drug abuse and liver dysfunction. If cocaine or heroin cause oxidative stress to hepatic tissues this may result in detectable alterations in liver function; 3) To examine the association between oxidative damage and liver dysfunction. An association between oxidative stress and liver dysfunction will imply that drug abuse alters liver function through a mechanism involving oxidative stress; and 4) To examine the influence of infection with HIV, infection with HCV, and alcohol consumption on the associations described in specific aims 1 to 3. This will determine if drug abuse is an independent risk factor for liver dysfunction or whether, like alcohol, it is an accelerator of liver dysfunction in persons with HIV and/or HCV infection. The proposed study will build on the infrastructure of the BIENESTAR study (NIDA DA 11598) and the BIENESTAR-micronutrient study (NIDA DA 14501).

描述（由申请人提供）：BIENESTAR研究是一项关于药物滥用对HIV感染的西班牙裔美国人营养状况和结局影响的纵向队列研究。该队列由3组组成：HIV+药物滥用者、HIV-药物滥用者和HIV+非药物滥用者。工作重点将是扩大和维持这一独特的群体。在这一竞争性更新中提出的新假设反映了当前的趋势，因为艾滋病毒已成为一种慢性疾病。肝病是艾滋病毒感染者越来越常见的并发症。虽然人们普遍认为HCV是HIV感染者肝脏疾病的主要原因，但研究表明，药物滥用本身就是HCV感染者肝脏疾病的风险因素。动物研究表明，可卡因可通过诱导组织损伤的氧化应激引起肝毒性。美国东北部的西班牙裔比其他种族更喜欢注射可卡因，因此可能会增加氧化应激和肝功能障碍的风险。低血清抗氧化微量营养素水平在药物滥用者中很常见，进一步增加了氧化组织损伤的风险。本研究旨在探讨抗氧化状态，氧化应激和肝功能障碍的西班牙裔药物滥用者与艾滋病毒感染。有四个具体目标：1）研究药物滥用类型（可卡因与海洛因）和频率与血浆抗氧化能力和氧化应激之间的关系。具体的兴趣是要知道，如果可卡因不同于海洛因在其改变抗氧化能力和引起氧化应激的能力; 2）检查药物滥用的类型和频率与肝功能障碍之间的关联。如果可卡因或海洛因对肝组织造成氧化应激，这可能导致可检测到的肝功能改变; 3）检查氧化损伤与肝功能障碍之间的关系。氧化应激和肝功能障碍之间的关联意味着药物滥用通过涉及氧化应激的机制改变肝功能;以及4）检查HIV感染、HCV感染和饮酒对具体目标1至3中描述的关联的影响。这将确定药物滥用是否是肝功能障碍的独立风险因素，或者是否像酒精一样，它是HIV和/或HCV感染者肝功能障碍的加速剂。拟议的研究将建立在BIENESTAR研究（NIDA DA 11598）和BIENESTAR-微量营养素研究（NIDA DA 14501）的基础设施上。