Micronutrient Metabolism in HIV+and HIV-Drug Users

描述：(申请人提供)拟进行的研究 感染艾滋病毒的吸毒者，是为了回应一项关于医学的研究计划 和药物滥用的健康后果，以及NIDA关于新陈代谢和 药物滥用和艾滋病毒感染引起的内分泌并发症。穷 血清/血浆微量营养素状况在有无吸毒者中很常见 爱滋病毒。低微量营养素水平与不良反应有关。 艾滋病毒感染的后果。先前的研究表明，营养不良 吸毒者的状况不能完全归因于饮食摄入量。 关于药物的非饮食机制的研究发表得很少 吸毒者，无论是否感染艾滋病毒，都可能出现血液中微量营养素水平低下的情况。 影响微量营养素状况的非饮食因素可能包括吸收不良， 新陈代谢异常，排泄增加，需求量增加。 吸收不良、肝脏和肾脏功能障碍在吸毒者中都很常见。 此外，吸毒者经常吸烟和酗酒，这是 已知会影响某些微量营养素的新陈代谢。在此，我们建议 检查微量营养素代谢的某些方面以确定机制 导致血液中的低水平。我们将重点关注抗氧化剂 微量营养素维生素A和E，类胡萝卜素，硒和锌，它们是 代谢性的相互代谢相关的具体来说，我们将：1)确定 低至边际血清微量营养素维生素A水平的流行率， 三组吸毒者的β-胡萝卜素、维生素E、硒和锌 艾滋病毒携带者、未感染艾滋病毒的吸毒者和未感染艾滋病毒的非吸毒者。2)确定 吸收不良与血清微量营养素水平之间的关系(列于 具体目标1)。3)确定运输级别之间的关联 因素和血清微量营养素水平。4)确定肝脏或肾脏的作用 微量营养素转运因子与低氧相关性的功能障碍 达到边际血清微量营养素水平。拟议的研究将建立在 现有的Bienestar研究(NIDA DA11598)，并补充正在进行的唐代研究 (耐达DA10252)。这项研究的长期目标是开发有效的 改善药物营养状况和健康结果的干预措施 患有和不患有包括艾滋病毒在内的传染病的滥用者。

DESCRIPTION: (provided by applicant) The proposed research, to be done in HIV-infected drug abusers, is in response to a research program on the medical and health consequences of drug abuse and a program at NIDA on metabolic and endocrine complications of drug substance abuse and HIV infection. Poor serum/plasma micronutrient status is common in drug abusers with and without HIV. Low micronutrient levels have been associated with adverse outcomes in HIV infection. Previous studies suggest that poor nutritional status among drug abusers cannot be attributed entirely to dietary intake. Little research has been published on non-dietary mechanisms by which drug abusers, with and without HIV, may develop low blood levels of micronutrients. Non-dietary factors affecting micronutrient status may include malabsorption, abnormal metabolism, increased excretion, and increased requirements. Malabsorption, liver, and renal dysfunction are all common among drug abusers. Furthermore, drug abusers often smoke cigarettes and abuse alcohol, which are known to affect the metabolism of some micronutrients. Here, we propose to examine some aspects of micronutrient metabolism to identify mechanisms contributing to low blood levels. We will focus on the antioxidant micronutrients vitamins A and E, the carotenoids, selenium and zinc, which are metabolically related to one another. Specifically we will: 1) Determine the prevalence of low to marginal serum levels of the micronutrients vitamin A, beta-carotene, vitamin E, selenium and zinc among three groups: drug abusers with HIV, drug abusers without HIV and non-drug abusers with HIV. 2) Determine the association between malabsorption and serum icronutrient levels (listed in specific aim 1). 3) Determine the association between levels of transportation factors and serum micronutrient levels. 4) Determine the role of liver or renal dysfunction in the association between micronutrient transport factors and low to marginal serum micronutrient levels. The proposed study will build on the existing BIENESTAR study (NIDA DA11598), and complement the ongoing TANG study (NIDA DA10252). The long term goal of this research is to develop effective interventions to improve the nutritional status and health outcomes of drug abusers with and without infectious diseases, including HIV.