Influence of Lactation on Postpartum Stress and Immunity
哺乳对产后压力和免疫力的影响
基本信息
- 批准号:7373849
- 负责人:
- 金额:$ 35.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-08-01 至 2011-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAnti-Inflammatory AgentsAnti-inflammatoryAntigen PresentationAtherosclerosisAutoantibodiesAutoimmune DiseasesAutoimmune ProcessAutoimmunityBiologicalBiological MarkersBiologyBreast FeedingCD40 LigandCD8B1 geneCardiovascular DiseasesCellsCellular ImmunityChronic DiseaseClassComplementCross-Sectional StudiesDevelopmentDiscipline of NursingDiseaseEndocrineEndocrinologyEnvironmentEnvironmental Risk FactorEnzymesEpithelialEstrogensFemaleFlareFunctional disorderFundingGeneticGrantGraves&apos DiseaseHLA-DR AntigensHealthHealth SciencesHigh Risk WomanHormonesHydrocortisoneHypothyroidismIL2RA geneImmuneImmune responseImmune systemImmunityImmunologyIncidenceInfectionInflammationInflammatoryInflammatory ResponseInvestigationIodide PeroxidaseJournalsL-SelectinLactationMaternal HealthMeasuresMediator of activation proteinMental HealthModelingMoodsMothersMultiple SclerosisNCAM1 geneNumbersOutcomePathogenesisPatternPeptidesPerceptionPhasePhysiologyPlayPostpartum PeriodPostpartum WomenPregnancyProcessProgesteroneProlactinProteinsPsychoneuroimmunologyPublic HealthPublicationsRateResearchRheumatoid ArthritisRiskRoleStressSymptomsT-Cell ActivationT-LymphocyteTNFRSF5 geneThyroid DiseasesThyroid GlandThyroiditisThyrotropinThyroxineTimeUp-RegulationWeekWomanWorkbasecritical developmental periodcytokineexperienceimprovedinterestlensmortalitypreventprospectivereproductive
项目摘要
DESCRIPTION (provided by applicant): This revised competing continuation proposal is a request for funding to explore the patterns of immune, endocrine, and inflammatory changes over the postpartum period and to analyze potential relationships between these variables and trajectories as well as the development of postpartum thyroiditis (PPT), a common autoimmune disease of the postpartum. The initial funded project explored the relationship between lactation status and stress and immunity in postpartum mothers. The major findings from that cross sectional study were the presence of significant upregulation of cytokines and proteins and inflammatory responses in 4-6 week postpartum women compared to controls. This has led to the competing continuation request that seeks to explore the pattern of these changes over time, from the first week through the sixth postpartum month, in healthy control mothers and mothers at risk for PPT. This prospective approach will also allow us to examine relationships among endocrine, demographic, stress, mood and immunity variables and determine which of these variables predict and accompany onset and course of PPT. Many autoimmune diseases flare or have their onset in the postpartum, and breastfeeding increases risk. We will use PPT as a model of autoimmune disease, and identify low and high risk for PPT groups on the basis of the presence or absence of thyroid peroxidase enzyme (TPO) autoantibodies measured during pregnancy. We will prospectively study relationships between immune and inflammatory processes and trajectories, breastfeeding status, postpartum hormones, stress and dysphoric moods, general health, and the onset and course of PPT, which we anticipate will occur in about 50% of the TPO+ mothers. In addition, exploration of the normal changes in immunity, inflammation, and hormones in TPO- mothers will provide new understanding about the physiology of the postpartum, and will lay the groundwork for relating this physiology to many maternal health outcomes.
The significance of this research to public health lies in the prominent incidences of autoimmune diseases in women, and the debilitating and long-term chronic illnesses that result from autoimmune processes. Genetics only plays a part in the pathogenesis of these illnesses, and the role of environment is critical to understand. The immunology and endocrinology of the postpartum provides a lens through which to study autoimmune disease, as the postpartum is a critical period for development or exacerbation of many autoimmune diseases.
描述(由申请人提供):这份修订后的竞争性继续申请是一份资金申请,旨在探索产后期间免疫、内分泌和炎症变化的模式,并分析这些变量和轨迹之间的潜在关系,以及产后甲状腺炎(PPT)的发展,PPT是一种常见的产后自身免疫性疾病。初步资助的项目探讨了产后母亲哺乳状态与应激和免疫的关系。横断面研究的主要发现是,与对照组相比,产后4-6周的妇女细胞因子、蛋白质和炎症反应显著上调。这导致了竞争性的持续要求,旨在探索这些变化随时间的模式,从产后第一周到产后第六个月,在健康对照母亲和有PPT风险的母亲中。这种前瞻性方法也将使我们能够检查内分泌、人口统计学、压力、情绪和免疫变量之间的关系,并确定哪些这些变量预测和伴随PPT的发病和病程。许多自身免疫性疾病在产后发作或发病,母乳喂养会增加风险。我们将使用PPT作为自身免疫性疾病的模型,并根据妊娠期间甲状腺过氧化物酶(TPO)自身抗体的存在或缺失来确定PPT组的低风险和高风险。我们将前瞻性地研究免疫和炎症过程和轨迹、母乳喂养状况、产后激素、压力和烦躁情绪、一般健康状况以及PPT的发病和病程之间的关系,我们预计大约50%的TPO+母亲会发生PPT。此外,探索TPO-母亲在免疫、炎症和激素方面的正常变化将提供对产后生理学的新认识,并将为将这种生理学与许多产妇健康结果联系起来奠定基础。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Maureen Edith Groer其他文献
Maureen Edith Groer的其他文献
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{{ truncateString('Maureen Edith Groer', 18)}}的其他基金
Chronic Toxoplasma gondii, Pregnancy reactivation, and Perinatal Depression
慢性弓形虫、妊娠再激活和围产期抑郁
- 批准号:
10164827 - 财政年份:2017
- 资助金额:
$ 35.83万 - 项目类别:
Chronic Toxoplasma gondii, Pregnancy reactivation, and Perinatal Depression
慢性弓形虫、妊娠再激活和围产期抑郁
- 批准号:
9382334 - 财政年份:2017
- 资助金额:
$ 35.83万 - 项目类别:
The Preterm Infant Microbiome: Biological, Behavioral and Health Outcomes at 2 and 4 years of Age
早产儿微生物组:2 岁和 4 岁时的生物学、行为和健康结果
- 批准号:
8857645 - 财政年份:2015
- 资助金额:
$ 35.83万 - 项目类别:
The Preterm Infant Microbiome: Biological, Behavioral and Health Outcomes at 2 and 4 years of Age
早产儿微生物组:2 岁和 4 岁时的生物学、行为和健康结果
- 批准号:
9237123 - 财政年份:2015
- 资助金额:
$ 35.83万 - 项目类别:
The Preterm Infant Microbiome: Biological, Behavioral and Health Outcomes at 2 and 4 years of Age
早产儿微生物组:2 岁和 4 岁时的生物学、行为和健康结果
- 批准号:
9066791 - 财政年份:2015
- 资助金额:
$ 35.83万 - 项目类别:
The association between preterm milk immunobiology and infant health
早产儿乳汁免疫生物学与婴儿健康之间的关联
- 批准号:
8305914 - 财政年份:2012
- 资助金额:
$ 35.83万 - 项目类别:
The association between preterm milk immunobiology and infant health
早产儿乳汁免疫生物学与婴儿健康之间的关联
- 批准号:
8440286 - 财政年份:2012
- 资助金额:
$ 35.83万 - 项目类别:
Influence of Lactation on Postpartum Stress and Immunity
哺乳对产后压力和免疫力的影响
- 批准号:
7811071 - 财政年份:2009
- 资助金额:
$ 35.83万 - 项目类别:
Influence of Lactation on Postpartum Stress and Immunity
哺乳对产后压力和免疫力的影响
- 批准号:
7496121 - 财政年份:2001
- 资助金额:
$ 35.83万 - 项目类别:
Influence of Lactation on Postpartum Stress and Immunity
哺乳对产后压力和免疫力的影响
- 批准号:
7847448 - 财政年份:2001
- 资助金额:
$ 35.83万 - 项目类别:
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