Chronic Toxoplasma gondii, Pregnancy reactivation, and Perinatal Depression

慢性弓形虫、妊娠再激活和围产期抑郁

• 批准号: 9382334
• 负责人: Maureen Edith Groer
• 金额: $ 56万
• 依托单位: UNIVERSITY OF SOUTH FLORIDA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-12 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9382334
• 关键词: Age; Animals; Antibodies; Appearance; Behavior; Behavior Control; Behavioral; Biochemical; Brain; Characteristics; Chorioretinitis; Chronic; Cicatrix; Control Groups; Country; Cyst; DNA; Encapsulated; Ethnic Origin; Fetus; Frequencies; Functional disorder; Generations; Goals; High Risk Woman; Hispanics; Human; Immune; Immunocompetent; Immunoglobulin G; Immunosuppression; Incidence; Individual; Infection; Inflammation; Knowledge; Kynurenine; Lead; Lesion; Literature; Measurable; Measures; Mental Depression; Metabolism; Migraine; Moods; Mothers; Muscle; Neuroimmune; Outcome; Parasites; Perinatal; Pharmacotherapy; Placenta; Plasma; Population; Postpartum Period; Pregnancy; Pregnant Women; Primary Infection; Reactive depression; Reporting; Research; Retinal; Risk; Rodent Model; Role; Schizophrenia; Second Pregnancy Trimester; Serotyping; Social support; Stream; Stress; Suicide; Symptoms; Toxoplasma gondii; Toxoplasmosis; Tryptophan; Tryptophan Metabolism Pathway; Umbilical Cord Blood; United States; Virulent; Woman; Work; antepartum depression; behavioral study; brain tissue; cohort; cytokine; depressive symptoms; fetal; fetal blood; high risk population; immunosuppressed; latent infection; peripartum depression; psychologic; reactivation from latency; relating to nervous system; response; seropositive; socioeconomics; symptomatology; transmission process

Project Summary/Abstract Toxoplasma gondii is a ubiquitous parasite that infects one third of the world's population. It remains in a latent state, encapsulated in cysts in the brain and muscle tissue of infected hosts. Reactivation rarely occurs, and usually only when the host has become significantly immunosuppressed. However, emerging literature suggests that chronic, latent infection is not innocuous. There have been reports associating depression, schizophrenia, suicidality, unusual behaviors, and migraine headaches with T. gondii IgG titers in chronically infected individuals. In addition, a few reports suggest that T. gondii can reactivate in healthy, immunocompetent pregnant women. These relationships have not yet been studied systematically in perinatal women. This proposal will study the relationships between latent T.gondii infection and depression through pregnancy and the early postpartum in T. gondii positive Hispanic women. Hispanic women are at highest risk for the type 1 serotype and a new highly virulent strain. Studies of behavioral and mood effects of T. gondii infection in both rodent models and humans have been done, but not in perinatal women. The research team has reported a relationship between T. gondii IgG titers and depression in second trimester pregnant women. In the proposed study, the role of socioeconomics and country of origin, cytokines, and immunosuppression will be determined across pregnancy. The relationship between IgG titer and depression in the postpartum will also be studied. A T. gondii negative control group will provide comparison. The second goal is to determine the true incidence of T. gondii reactivation in pregnant women with latent T. gondii infection. Women with positive IgG titers will be followed through pregnancy for changes in titer, symptoms, and for those with retinal scars, evidence of reactivation of chorioretinitis. The third goal is to explore the possibility of live tachyzoites transiting across the placenta into the fetal blood stream in T. gondii positive women.

项目摘要/摘要 弓形虫是一种普遍存在的寄生虫，感染了世界三分之一的人口。它仍然在一个 潜伏状态，包裹在受感染宿主的脑囊和肌肉组织中。很少重新激活 通常只有当宿主的免疫受到显著抑制时才会发生。然而，新兴的 文献表明，慢性潜伏感染并不是无害的。有报道称， 伴弓形虫抗体滴度的抑郁症、精神分裂症、自杀、异常行为和偏头痛 在慢性感染者身上。此外，一些报告表明弓形虫可以在健康的， 具有免疫能力的孕妇。这些关系还没有得到系统的研究。 围产期妇女。 这项建议将通过以下途径研究弓形虫潜伏感染与抑郁症的关系 弓形虫阳性拉美裔妇女的妊娠和产后早期。西班牙裔女性比例最高 1型血清型和一种新的高毒力毒株的风险。行为和情绪效应研究。 在啮齿动物模型和人类中都已经进行了弓形虫感染，但在围产期妇女中没有。这个 研究小组报告了弓形虫Ig G滴度与妊娠中期抑郁的关系 怀孕的女人。在拟议的研究中，社会经济学和原籍国、细胞因子和 免疫抑制将在怀孕期间确定。血清免疫球蛋白抗体滴度与免疫球蛋白的关系 产后抑郁也将被研究。弓形虫阴性对照组将提供 比较一下。 第二个目标是确定潜伏感染弓形虫孕妇体内弓形虫重新激活的真实发生率。 弓形虫感染。免疫球蛋白滴度阳性的妇女将在整个怀孕期间接受滴度变化的跟踪调查， 症状，以及那些有视网膜疤痕的人，有脉络膜视网膜炎重新激活的证据。 第三个目标是探索活的速殖子穿过胎盘进入胎儿的可能性。 弓形虫阳性妇女的血流情况。