Individual Cognitive-Behavioral Psychotherapy for IED

描述(由申请人提供)：间歇性爆炸障碍(IED)越来越被认为是一种常见的、可能导致残疾的精神疾病。尽管如此，目前还没有针对IED患者的经验性行为治疗。这项拟议的研究的目的是评估认知行为疗法(CBT)治疗IED的短期和长期疗效，此前发现CBT在治疗功能障碍愤怒方面是成功的。该项目的次要目标是(A)探索IED成功治疗所涉及的机制，以及(B)检查与治疗反应相关的个体差异。申请以患者为导向的科学家导师奖(K23)是为了培养候选人在随机临床试验、高级生物统计学方法和认知神经科学方面的研究敏锐性。符合当前研究和当前DSM IED标准的90名受试者将被随机分配到12周的CBT或12周的支持性心理治疗控制条件下。受试者将在治疗前和治疗后以及6个月和12个月的随访时进行评估。主要结果评估将在治疗后、6个月随访和12个月随访时评估攻击性行为、愤怒和IED诊断的存在。社会和情绪信息处理将被评估为潜在的变化机制。特质攻击性将被评估为一个潜在的调节变量。

DESCRIPTION (provided by applicant): Intermittent Explosive Disorder (IED) is increasingly acknowledged as a common, potentially disabling psychiatric condition. Despite this, there are currently no empirically supported behavioral treatments for patients with IED. The purpose of the proposed study is to assess the short-term and long-term efficacy of a cognitive-behavioral treatment (CBT), previously found to be successful in treating dysfunctional anger, for treating IED. Secondary goals of the project are to (a) explore mechanisms involved in the successful treatment of IED, and (b) examine individual differences associated with treatment response. This request for a Patient-Oriented Mentored Scientist Award (K23) serves to cultivate the candidate's research acumen as it relates to randomized clinical trials, advanced biostatistical methodologies, and cognitive neuroscience. Ninety subjects meeting criteria for both current research and current DSM IED criteria will be randomly assigned to either 12 weeks of CBT or 12 weeks of a supportive psychotherapy control condition. Subjects will be assessed before and after therapy as well as at 6 month and 12 month follow-up. Primary outcome measures will assess aggressive behavior, anger, and the presence of an IED diagnosis at post-treatment, 6-month follow-up and 12-month follow-up. Social and emotional information processing will be evaluated as potential mechanism of change. Trait aggression will be assessed as a potential moderating variable.