Emotional Information Processing & IED: An fMRI Study

该项目的具体目标是研究神经解剖学之间的关系， 通路和情绪信息处理缺陷的个体间歇性爆发性障碍（IED）。为了实现这个目标。两组个人：16名患有lED的参与者和16名没有任何临床精神病理学的参与者将被要求在一小时的功能成像会话期间完成两项情感信息处理任务（情感计数stroop和情感面孔任务）。这两项任务都将采用区组设计。任务将在各个科目之间平衡。情绪计数stroop任务将由屏幕上呈现的1-4个单词组成，受试者识别屏幕上显示了多少单词。使用了四种类型的词：积极的（例如，快乐，小狗），中性的 (e.g.水槽，椅子），一般负面（例如呕吐，后悔）和愤怒（例如愤怒，白痴）。这些词是根据以前的研究选择的。作者的初步研究表明，与中性词相比，患有lED的人在显示愤怒词时反应更慢，准确性更低。 在情绪面孔任务中，参与者会间歇性地看到愤怒、中性、恐惧或快乐的表情。在前两次运行期间，他们将被要求使用右手上的两个2按钮响应面板识别面部的性别。在后两次运行中，参与者将被要求注意图片的情感表达，但不会被要求做出回应。过去的研究表明，患有许多临床疾病（例如边缘型人格障碍，重度抑郁症）的人表现出识别某些类型的情感面孔的能力受损。然后，参与者将识别fMRI环境之外的情绪面孔。最近的研究表明，lED患者在识别情绪面孔方面不如对照组准确。假设lED受试者将（1）在呈现愤怒词语时，在情绪stroop任务中的准确性低于控制受试者，（2）在识别情绪面孔时的准确性低于控制受试者 受试者，和（3）表现出不同的模式的大脑激活情绪的面孔和话，包括增加杏仁核激活恐惧的话和面孔和减少眶额活动的愤怒的话和面孔。

The specific aim of the proposed project is to examine the relationship between neuroanatomical pathways and emotional information processing deficits among individuals with Intermittent Explosive Disorder (lED). To accomplish this goal. Two groups of individuals: 16 participants with lED and 16 participants who are free of any clinical psychopathology, will be asked to complete two tasks of emotional information processing (the emotional counting stroop and the emotional faces task) during a one-hour functional imaging session. Both tasks will be presented using a block design. Tasks will be counterbalanced across subjects. The emotional counting stroop task will consist of 1-4 words presented on a screen, to which the subject identifies how many words were shown. Four types of words are used: positive (e.g. happy, puppy), neutral (e.g. sink, chair), general negative (e.g. vomit, regret) and anger (e.g. fury, idiot). Words were selected based on previous research. Pilot research by the authors suggest that individuals with lED are slower and less accurate when anger words are shown as compared to neutral words. During the emotional faces task, participants will intermittently be shown faces with angry, neutral, fearful, or happy expressions. During the first two runs they will be asked to identify the gender of the face presented using two 2-button response panels on their right hand. During the latter two runs participants will be asked to note the emotional expression of the pictures, but will not be asked to make a response. Past research has shown that individuals with a number of clinical disorders (e.g. Borderline Personality Disorder, Major Depression) exhibit an impaired ability to identify some types of emotional faces. Participants will then identify the emotional faces outside of the fMRI environment. Recently it has been demonstrated that lED patients are less accurate in identifying emotional faces than control subjects. It is hypothesized that lED subjects will (1) be less accurate at the emotional stroop tasks than control subjects when anger words are presented, (2) be less accurate at identifying emotional faces than control subjects, and (3) show a differential pattern of brain activation to emotional faces and words including increased amygdala activation for fear words and faces and decreased orbitofrontal activity for anger words and faces.