Emotional Information Processing & IED: An fMRI Study

拟议项目的具体目标是检查神经解剖学和神经解剖学之间的关系 间歇性爆发性精神障碍(LED)个体的情绪信息处理缺陷和通路。来实现这一目标。两组人：16名患有LED的参与者和16名没有任何临床精神病理学的参与者，将被要求在一小时的功能成像过程中完成两项情绪信息处理任务(情绪计数闪光灯和情绪面孔任务)。这两项任务都将使用模块设计进行演示。任务将在不同的主题之间进行平衡。情绪计数跳跃任务将由屏幕上呈现的1-4个单词组成，受试者识别显示了多少个单词。使用了四种类型的词：积极的(例如，快乐的，小狗的)，中性的 (如水槽、椅子)、一般负面(如呕吐、后悔)和愤怒(如愤怒、白痴)。词汇的选择是基于之前的研究。作者的初步研究表明，与中性词语相比，患有LED的人在表达愤怒的话时速度更慢，准确度也更低。 在情绪面孔任务中，参与者会断断续续地看到愤怒、中立、恐惧或高兴的表情。在前两次跑步中，他们将被要求使用右手上的两个两按钮响应面板来识别所展示的人脸的性别。在后两次跑步中，参与者将被要求注意图片的情感表达，但不会被要求做出回应。过去的研究表明，患有一些临床障碍(如边缘人格障碍、严重抑郁)的人，对某些类型的情绪面孔的识别能力受到了损害。然后，参与者将识别fMRI环境之外的情绪面孔。最近已经证明，LED患者在识别情绪面孔方面不如对照受试者准确。假设被试(1)在情绪激越任务中的准确度低于控制组，(2)在识别情绪面孔方面不如控制组 (3)情绪面孔和词汇的大脑激活模式不同，包括对恐惧词汇和面孔的杏仁核激活增加，对愤怒词汇和面孔的眼眶前额叶活动减少。

The specific aim of the proposed project is to examine the relationship between neuroanatomical pathways and emotional information processing deficits among individuals with Intermittent Explosive Disorder (lED). To accomplish this goal. Two groups of individuals: 16 participants with lED and 16 participants who are free of any clinical psychopathology, will be asked to complete two tasks of emotional information processing (the emotional counting stroop and the emotional faces task) during a one-hour functional imaging session. Both tasks will be presented using a block design. Tasks will be counterbalanced across subjects. The emotional counting stroop task will consist of 1-4 words presented on a screen, to which the subject identifies how many words were shown. Four types of words are used: positive (e.g. happy, puppy), neutral (e.g. sink, chair), general negative (e.g. vomit, regret) and anger (e.g. fury, idiot). Words were selected based on previous research. Pilot research by the authors suggest that individuals with lED are slower and less accurate when anger words are shown as compared to neutral words. During the emotional faces task, participants will intermittently be shown faces with angry, neutral, fearful, or happy expressions. During the first two runs they will be asked to identify the gender of the face presented using two 2-button response panels on their right hand. During the latter two runs participants will be asked to note the emotional expression of the pictures, but will not be asked to make a response. Past research has shown that individuals with a number of clinical disorders (e.g. Borderline Personality Disorder, Major Depression) exhibit an impaired ability to identify some types of emotional faces. Participants will then identify the emotional faces outside of the fMRI environment. Recently it has been demonstrated that lED patients are less accurate in identifying emotional faces than control subjects. It is hypothesized that lED subjects will (1) be less accurate at the emotional stroop tasks than control subjects when anger words are presented, (2) be less accurate at identifying emotional faces than control subjects, and (3) show a differential pattern of brain activation to emotional faces and words including increased amygdala activation for fear words and faces and decreased orbitofrontal activity for anger words and faces.