ANTERIOR CINGULATE ACTIVATION IN GERIATRIC DEPRESSION

老年抑郁症中的前扣带回激活

• 批准号: 7241571
• 负责人: Faith M Gunning
• 金额: $ 16.79万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-15 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7241571
• 关键词: Affective; Age; Aging; Anterior; Area; Award; Cerebrum; Classification; Clinical; Clinical Trials; Cognitive; Condition; Daily; Data; Data Analyses; Depressed mood; Development; Dorsal; Dose; Elderly; Electrophysiology (science); Emotional; Environment; Escitalopram; Exhibits; Functional Magnetic Resonance Imaging; Functional disorder; Future; Generations; Geriatric Psychiatry; Goals; Growth; Institutes; Knowledge; Longitudinal Studies; Magnetic Resonance Imaging; Major Depressive Disorder; Mental Depression; Mentors; Methodology; Methods; Mood Disorders; Moods; National Institute of Mental Health; Neuroanatomy; Neurobiology; Paper; Pathogenesis; Patients; Pennsylvania; Performance; Pilot Projects; Publications; Research; Research Personnel; Research Project Grants; Research Training; Role; Scientist; Structure; Symptoms; Testing; Training; Universities; Week; Work; Writing; affective neuroscience; base; career; design; experience; follow-up; geriatric depression; information gathering; instrument; neurobehavioral; neuropsychological; patient oriented; programs; response; skills

DESCRIPTION (provided by applicant): This proposal is for a K23 Patient-Oriented Mentored Scientist Award. The applicant is a clinical neuropsychologist with research training and publications on structural and functional MRI correlates of aging. The goal of the proposal is to support the applicant's growth into an independent investigator, whose research focuses on the neurobiology of geriatric depression, using cognitive and affective neuroscience approaches. Neuropsychological, electrophysiology, and structural MRI findings suggest that anterior cingulate (ACC) dysfunction contributes to the pathogenesis of late-life depression and some of these abnormalities even influence the response of depression to treatment. fMRI offers a more direct approach to investigate ACC dysfunction that may underlie cognitive and affective disturbance in late-life depression. The training and research proposed in this application aims to prepare the applicant to become an effective independent investigator in the neurobiology of late-late mood disorders. Coursework, seminars, tutorials, collaborative studies, and paper writing all were planned with the goal of giving the applicant substantive knowledge in the cognitive and affective neuroscience of depression, skills in fMRI task development and data analysis, and training in clinical trials methodology. The training environment (Weill Cornell Institute of Geriatric Psychiatry) is a Center with findings and a research agenda focused on the role of ACC in geriatric depression and thus would be fertile ground for the applicant's growth. Mentors and experts from Cornell, NIMH, Harvard, University of Pennsylvania, and NKI were selected with complementary expertise in areas relevant to the applicant's training needs. The training experience was designed in a way that the applicant has the opportunity to benefit maximally from interaction with her mentors. Moreover, the applicant will pursue a research project that can function as the training ground for accomplishing her educational aims. The project will use neurobehavioral probes to elicit activation of the ACC in geriatric depressed patients and age-matched comparison subjects. The project hypothesizes that 1) In both groups, cognitive interference conditions and negatively valenced word conditions will elicit differential activation of the ACC; 2) In response to cognitive and emotional probes, activation in the dorsal and perigenual ACC will distinguish geriatric depressed patients from comparison subjects.

描述(由申请者提供)：这项建议是为K23以患者为导向的指导性科学家奖。申请者是一名临床神经心理学家，在结构和功能磁共振成像与衰老的相关性方面进行了研究、培训和出版。该提案的目标是支持申请者成长为独立的调查者，其研究重点是使用认知和情感神经科学方法研究老年性抑郁症的神经生物学。神经心理学、电生理学和结构MRI结果提示，扣带回前部功能障碍参与了老年抑郁症的发病机制，其中一些异常甚至影响抑郁症的治疗反应。功能磁共振成像提供了一种更直接的方法来研究ACC功能障碍，该功能障碍可能是老年抑郁症认知和情感障碍的基础。 本申请中提出的培训和研究旨在使申请者做好准备，成为晚-晚情绪障碍神经生物学方面的有效独立研究员。课程、研讨会、教程、协作研究和论文写作都是为了给申请者提供抑郁症认知和情感神经科学方面的实质性知识，功能磁共振任务开发和数据分析的技能，以及临床试验方法学方面的培训。培训环境(威尔康奈尔老年精神病学研究所)是一个中心，有研究结果和研究议程，重点是ACC在老年抑郁症中的作用，因此将是申请者成长的沃土。来自康奈尔大学、NIMH、哈佛大学、宾夕法尼亚大学和NKI的导师和专家被选中，他们在与申请者培训需求相关的领域具有互补的专业知识。培训体验的设计使申请者有机会从与导师的互动中最大限度地受益。此外，申请者还将从事一项研究项目，该项目可以作为实现其教育目标的培训基础。该项目将使用神经行为探测器在老年抑郁症患者和年龄匹配的对照受试者中诱导ACC的激活。该项目假设：1)在两组中，认知干扰条件和负价词汇条件将导致ACC的不同激活；2)在认知和情绪探测的反应中，背侧和周围ACC的激活将区分老年抑郁症患者和对照组。