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TB Clinical Research: Training the Next Generation

结核病临床研究：培训下一代

基本信息

批准号：
7208039
负责人：
Carol D Hamilton
金额：
$ 9.92万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-07-01 至 2009-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7208039
关键词：
AIDS clinical trial group Academia Academic Medical Centers Academic Training Achievement Acquired Immunodeficiency Syndrome Address Adopted Adult Advanced Practice Nurse Advisory Committees Advocacy Advocate Affect Africa South of the Sahara Agreement Alabama Alcoholism Alcohols Alzheimer&apos s Disease Ambulatory Care Facilities American Americas Anti-Retroviral Agents Antibiotics Antitubercular Agents Appendix Applaud Applications Grants Applied Research Appointment Area Attention Attitude Autistic Disorder Award Bangladesh Basic Science Behavior Behavioral Belief Benchmarking Benefits and Risks Bioinformatics Biological Biology Biometry Bioterrorism Birth Books Botswana Boxing Bronchiectasis Canada Candidate Disease Gene Cardiology Caregivers Caring Case-Control Studies Cell surface Cellular Tropism Centers for Disease Control and Prevention (U.S.)Cessation of life Chairperson Characteristics Chest Child Childhood Chronic Cities Class Clinic Clinical Clinical Investigator Clinical Research Clinical Trials Clinical Trials Cooperative Group Clinical Trials Design Clinical Trials-Pediatric AIDS Collaborations Collection Commit Committee Members Communicable Disease Control Communicable Diseases Communities Compassion Complex Computer Systems Concept Review Consensus Consult Consultations Consumption Contracts Coordination and Collaboration Core Facility Cost-Benefit Analysis Counseling Country County Creativeness Cutaneous DNA DNA Library Daily Data Data Analyses Data Collection Data Set Databases Daughter Depth Detection Development Diagnosis Diagnostic Diagnostic tests Dialysis patients Dialysis procedure Diarrhea Dietitian Dimensions Discipline of Nursing Discipline of obstetrics Disease District of Columbia Doctor of Medicine Doctor of Pharmacy Doctor of Philosophy Dose Drops Drug Interactions Drug Kinetics Drug Rehabilitation Centers Economic Factors Economics Education Educational Activities Educational Curriculum Educational Intervention Educational Status Educational process of instructing Educational workshop Effectiveness Electronic Mail Elements Employee Employee Strikes End Point Enrollment Ensure Environment Epidemic Epidemiologic Studies Epidemiologist Epidemiology Etiology Evaluation Evaluation Research Event Evolution Exhibits Expenditure Explosion Faculty Family Family Practice Family Study Fees Fellowship Financial Support Florida Follow-Up Studies Fostering Foundations Friends Fright Fruit Funding Funding Agency Future Future Generations Generations Genes Genetic Genomics Genus Mycobacterium Goals Government Agencies Grant Grouping Growth Guidelines Gynecology HIV HIV Infections HIV-1 Hand Head Health Health Professional Health Sciences Health Services Health Services Research Health Status Healthcare Hearing Hepatitis B Vaccines High Prevalence Highly Active Antiretroviral Therapy Hispanics Hospice Care Hospital Planning Hospitalization Hospitals Hour House Staffs Human Human Genetics Human Genome Human Resources Human immunodeficiency virus test Humor Immigrant Immunity Immunology Incidence India Indium Individual Industry Infection Infection Control Information Centers Information Technology Inpatients Institutes Institution Intelligence Interdisciplinary Study Internal Medicine International Internet Internship and Residency Internships Intervention Interview Investigation Investments Itraconazole Joints Journals K-Series Research Career Programs Knowledge Laboratories Laboratory Research Laboratory Study Lead Leadership Learning Left Letters Life Link Location Lung Lung diseases Lymphocyte Mails Manuscripts Master&apos s Degree Measures Medical Medical Microbiology Medical Students Medical center Medicine Melissa Mentored Clinical Oncology Award Mentored Clinical Scientist Award Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Metabolic Methodology Methods Microbiology Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Mission Modality Modeling Molecular Molecular Genetics Molecular Weight Monitor Monograph Morbidity - disease rate Mothers Multi-Drug Resistance Multi-Institutional Clinical Trial Multicenter Trials Multidrug-Resistant Tuberculosis Mycobacterium Infections Mycobacterium avium Complex Mycobacterium tuberculosis Mycoses NCI Scholars Program Names National Center for Research Resources National Institute of Allergy and Infectious Disease Nature Neopterin New Hampshire North Carolina Notification Nucleic Acid Amplification Tests Nucleic Acids Nucleosides Numbers Nurse Practitioners Nurses Nursing Research Nursing Schools Occupations Operations Research Operative Surgical Procedures Opportunistic Infections Organism Other Finding Outcome Outcome Study Outpatients Pain Pamphlets Parkinson Disease Participant Pathology Patient Care Patient Recruitments Patients Pattern Pediatrics Peer Review Performance Pericardial effusion Personal Satisfaction Persons Pharmaceutical Preparations Pharmacists Pharmacologic Substance Pharmacology Pharmacy Schools Pharmacy facility Phase Photocopying Physical Dialysis Physician Assistants Physician Executives Physicians Pilot Projects Play Pliability Policies Policy Research Population Positioning Attribute Postdoctoral Fellow Postpartum Period Predisposition Preparation Prevalence Prevalence Study Prevention Prevention strategy Preventive Preventive Medicine Primary Care Physician Primary Health Care Principal Investigator Private Practice Private Sector Problem Solving Process Production Productivity Professional Practice Prospective Studies Protease Inhibitor Protein Isoforms Protocols documentation Psychology Public Health Public Health Education Public Health Nurses Public Health Nursing Public Health Practice Public Health Schools Public Health Students Publications Published Comment Publishing Pulmonary Tuberculosis Purpose Qualifying Radiation Randomized Clinical Trials Range Rate Reaction Reading Recommendation Records Recruitment Activity Recurrent disease Reporting Research Research Activity Research Design Research Infrastructure Research Institute Research Methodology Research Peer Review Research Personnel Research Project Grants Research Support Research Training Residencies Resistance Resolution Resources Respiratory Tract Infections Restriction fragment length polymorphism Review Committee Review Literature Rewards Rifampin Risk Risk Factors Role Rotation Rural SECTM1 gene Safety Sample Size Saudi Arabia Schedule School Nursing Schools Science Scientist Series Services Severe Acute Respiratory Syndrome Site Site Visit Smallpox Societies Sodium Chloride Source South Carolina Specialist Sputum Staging Statistical Methods Structure Students Subgroup Supervision Surrogate Markers Surveys Susceptibility Gene System Tanzania Techniques Telefacsimile Telephone Temperament Test Result Testing Texas The science of Mycology Therapeutic Agents Thinking Time Tissue Banking Training Training Activity Training Programs Training and Education Translational Research Transplantation Travel Treatment Protocols Trust Tuberculosis Tuberculosis Vaccines Uncertainty United States United States Department of Veterans Affairs United States Dept. of Health and Human Services United States Food and Drug Administration United States National Academy of Sciences United States National Institutes of Health United States Public Health Service Universities University Hospitals Ursidae Family Utah Vaccinated Vaccines Vancomycin Vancomycin resistant enterococcus Vertical Disease Transmission Veterans Viral Viral Load result Vision Visit Voting Washington Week Withholding Treatment Work Writing Zimbabwe abstracting alcohol abuse therapy antiretroviral therapy base biodefense biomedical scientist care seeking career case control clinical research site clinically relevant college compare effectiveness computer design concept cooking cost cost effectiveness cysteine rich protein data management day design disorder control drug abuser effusion epidemiology study expectation experience facsimile falls follow-up follower of religion Jewish gene discovery genetic analysis genetic epidemiology health administration health economics hospice environment human disease improved interest intervention program isoniazid lectures macrophage medical schools member men microbial monocyte multidisciplinary mycobacterial next generation novel vaccines oncology patient oriented patient oriented research peer planetary Atmosphere prevent professor programs prospective protocol development quality assurance repository research and development research in practice research study respiratory response rifapentine role model school health skills social substance abuser success symposium synergism teacher therapeutic vaccine time use transmission process tuberculosis treatment vaccine development ward willingness

项目摘要

DESCRIPTION (provided by applicant): The Investigator, Carol Dukes Hamilton, M.D., will use NIH K24 funding to help train future generations of clinical-scientists for a career in tuberculosis (TB) research. TB is responsible for more human deaths than any other infectious disease. Dr. Hamilton's long-term research goals are to optimize strategies for treating active and latent TB in adults and children. Strengths of her program include ongoing funding and active participation in the CDC-funded TB Trials Consortium clinical trials group, the CDC-funded TB Epidemiologic Studies Consortium, and an NHLBI-funded study of genetics of TB susceptibility. These funded programs form the basis of her research enterprise. They combine perfectly with the opportunities afforded by her position as the Medical Director for North Carolina's TB Control Program, providing an avenue for subject recruitment, clinical and epidemiologic research training for advisees, and the opportunity to implement changes based on the findings. The strength of Dr. Hamilton's TB research program is that she employs both clinical trials and epidemiologic studies to attain her research goals. Trainees can tap into one or the other methodologies during their training. Didactic course work leading to either a Masters in Clinical Research Science or Public Health is an integral part of Dr. Hamilton's mentoring plan. Dr. Hamilton will also strengthen her experiencebased research capability using these resources. Dr. Hamilton's research plan includes a description of the TB Trials Consortium clinical trial, "Study 26", comparing the effectiveness of 9 months of daily isoniazid therapy to 12 doses of weekly isoniazid plus rifapentine, for treatment of latent TB infection. Planned and potential sub-studies and secondary analyses provide fertile substrate for trainee-initiated research projects. The research plan also includes her NHLBI funded genetic epidemiologic study of candidate genes that may contribute to human TB susceptibility. Her work with the Duke Center for Human Genetics is an example of translational research she hopes to foster within her mycobacteria research program.

描述（由申请人提供）：研究者，Carol Dukes汉密尔顿，医学博士，将利用NIH K24基金帮助培训未来几代临床科学家从事结核病（TB）研究。结核病比任何其他传染病造成更多的人类死亡。汉密尔顿博士的长期研究目标是优化治疗成人和儿童活动性和潜伏性结核病的策略。她的项目的优势包括持续资助和积极参与CDC资助的结核病试验联盟临床试验组，CDC资助的结核病流行病学研究联盟，以及NHLBI资助的结核病易感性遗传学研究。这些资助的项目构成了她的研究事业的基础。他们联合收割机完美地结合了她作为北卡罗来纳州结核病控制项目医学主任的职位所提供的机会，为受试者招募、临床和流行病学研究培训提供了一条途径，并有机会根据研究结果实施变革。汉密尔顿博士的结核病研究计划的优势在于她采用临床试验和流行病学研究来实现她的研究目标。受训者可以在培训期间采用其中一种方法。教学课程工作导致无论是在临床研究科学或公共卫生硕士是博士的一个组成部分。汉密尔顿的指导计划。汉密尔顿博士还将加强她的经验为基础的研究能力，利用这些资源。汉密尔顿博士的研究计划包括对结核病试验联盟临床试验“研究26”的描述，该研究比较了9个月的每日异烟肼治疗与12剂每周异烟肼加利福喷丁治疗潜伏性结核病感染的有效性。计划和潜在的子研究和二次分析为受训者发起的研究项目提供了肥沃的基础。该研究计划还包括她的NHLBI资助的可能导致人类结核病易感性的候选基因的遗传流行病学研究。她在杜克人类遗传学中心的工作是她希望在她的分枝杆菌研究计划中培养的转化研究的一个例子。