TB Clinical Research: Training the Next Generation

结核病临床研究：培训下一代

• 批准号: 7033841
• 负责人: Carol D Hamilton
• 金额: $ 9.71万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7033841
• 关键词: bioinformatics; clinical research; clinical trials; combination chemotherapy; drug administration rate /duration; drug screening /evaluation; epidemiology; genetic susceptibility; genotype; health care personnel; human genetic material tag; human subject; human therapy evaluation; isoniazid; latent bacterial disease; patient care management; patient oriented research; public health; respiratory disease /disorder therapy; respiratory disorder diagnosis; rifamycins; single nucleotide polymorphism; statistics /biometry; training; tuberculin test; tuberculosis

DESCRIPTION (provided by applicant): The Investigator, Carol Dukes Hamilton, M.D., will use NIH K24 funding to help train future generations of clinical-scientists for a career in tuberculosis (TB) research. TB is responsible for more human deaths than any other infectious disease. Dr. Hamilton's long-term research goals are to optimize strategies for treating active and latent TB in adults and children. Strengths of her program include ongoing funding and active participation in the CDC-funded TB Trials Consortium clinical trials group, the CDC-funded TB Epidemiologic Studies Consortium, and an NHLBI-funded study of genetics of TB susceptibility. These funded programs form the basis of her research enterprise. They combine perfectly with the opportunities afforded by her position as the Medical Director for North Carolina's TB Control Program, providing an avenue for subject recruitment, clinical and epidemiologic research training for advisees, and the opportunity to implement changes based on the findings. The strength of Dr. Hamilton's TB research program is that she employs both clinical trials and epidemiologic studies to attain her research goals. Trainees can tap into one or the other methodologies during their training. Didactic course work leading to either a Masters in Clinical Research Science or Public Health is an integral part of Dr. Hamilton's mentoring plan. Dr. Hamilton will also strengthen her experiencebased research capability using these resources. Dr. Hamilton's research plan includes a description of the TB Trials Consortium clinical trial, "Study 26", comparing the effectiveness of 9 months of daily isoniazid therapy to 12 doses of weekly isoniazid plus rifapentine, for treatment of latent TB infection. Planned and potential sub-studies and secondary analyses provide fertile substrate for trainee-initiated research projects. The research plan also includes her NHLBI funded genetic epidemiologic study of candidate genes that may contribute to human TB susceptibility. Her work with the Duke Center for Human Genetics is an example of translational research she hopes to foster within her mycobacteria research program.

描述（由申请人提供）：研究者，Carol Dukes汉密尔顿，医学博士，将利用NIH K24基金帮助培训未来几代临床科学家从事结核病（TB）研究。结核病比任何其他传染病造成更多的人类死亡。汉密尔顿博士的长期研究目标是优化治疗成人和儿童活动性和潜伏性结核病的策略。她的项目的优势包括持续资助和积极参与CDC资助的结核病试验联盟临床试验组，CDC资助的结核病流行病学研究联盟，以及NHLBI资助的结核病易感性遗传学研究。这些资助的项目构成了她的研究事业的基础。他们联合收割机完美地结合了她作为北卡罗来纳州结核病控制项目医学主任的职位所提供的机会，为受试者招募、临床和流行病学研究培训提供了一条途径，并有机会根据研究结果实施变革。 汉密尔顿博士结核病研究计划的优势在于她采用临床试验和流行病学研究来实现她的研究目标。受训者可以在培训期间采用其中一种方法。教学课程工作导致无论是在临床研究科学或公共卫生硕士是博士的一个组成部分。汉密尔顿的指导计划。汉密尔顿博士还将加强她的经验为基础的研究能力，利用这些资源。汉密尔顿博士的研究计划包括对结核病试验联盟临床试验“研究26”的描述，该研究比较了9个月的每日异烟肼治疗与12剂每周异烟肼加利福喷丁治疗潜伏性结核病感染的有效性。计划和潜在的子研究和二次分析为受训者发起的研究项目提供了肥沃的基础。该研究计划还包括她的NHLBI资助的可能导致人类结核病易感性的候选基因的遗传流行病学研究。她在杜克人类遗传学中心的工作是她希望在她的分枝杆菌研究计划中培养的转化研究的一个例子。