TB Clinical Research: Training the Next Generation

结核病临床研究：培训下一代

• 批准号: 6908217
• 负责人: Carol D Hamilton
• 金额: $ 6.78万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6908217
• 关键词: bioinformatics; clinical research; clinical trials; combination chemotherapy; drug administration rate /duration; drug screening /evaluation; epidemiology; genetic susceptibility; genotype; health care personnel; human genetic material tag; human subject; human therapy evaluation; isoniazid; latent bacterial disease; patient care management; patient oriented research; public health; respiratory disease /disorder therapy; respiratory disorder diagnosis; rifamycins; single nucleotide polymorphism; statistics /biometry; training; tuberculin test; tuberculosis

DESCRIPTION (provided by applicant): The Investigator, Carol Dukes Hamilton, M.D., will use NIH K24 funding to help train future generations of clinical-scientists for a career in tuberculosis (TB) research. TB is responsible for more human deaths than any other infectious disease. Dr. Hamilton's long-term research goals are to optimize strategies for treating active and latent TB in adults and children. Strengths of her program include ongoing funding and active participation in the CDC-funded TB Trials Consortium clinical trials group, the CDC-funded TB Epidemiologic Studies Consortium, and an NHLBI-funded study of genetics of TB susceptibility. These funded programs form the basis of her research enterprise. They combine perfectly with the opportunities afforded by her position as the Medical Director for North Carolina's TB Control Program, providing an avenue for subject recruitment, clinical and epidemiologic research training for advisees, and the opportunity to implement changes based on the findings. The strength of Dr. Hamilton's TB research program is that she employs both clinical trials and epidemiologic studies to attain her research goals. Trainees can tap into one or the other methodologies during their training. Didactic course work leading to either a Masters in Clinical Research Science or Public Health is an integral part of Dr. Hamilton's mentoring plan. Dr. Hamilton will also strengthen her experiencebased research capability using these resources. Dr. Hamilton's research plan includes a description of the TB Trials Consortium clinical trial, "Study 26", comparing the effectiveness of 9 months of daily isoniazid therapy to 12 doses of weekly isoniazid plus rifapentine, for treatment of latent TB infection. Planned and potential sub-studies and secondary analyses provide fertile substrate for trainee-initiated research projects. The research plan also includes her NHLBI funded genetic epidemiologic study of candidate genes that may contribute to human TB susceptibility. Her work with the Duke Center for Human Genetics is an example of translational research she hopes to foster within her mycobacteria research program.

描述（由申请人提供）：研究者Carol Dukes Hamilton， M.D，将使用NIH K24基金来帮助培养未来几代从事结核病（TB）研究的临床科学家。结核病造成的人类死亡人数超过任何其他传染病。汉密尔顿博士的长期研究目标是优化成人和儿童活动性和潜伏性结核病的治疗策略。她的项目优势包括持续资助和积极参与疾病控制和预防中心资助的结核病试验联盟临床试验组、疾病控制和预防中心资助的结核病流行病学研究联盟，以及nhlbi资助的结核病易感性遗传学研究。这些资助项目构成了她的研究事业的基础。这与她作为北卡罗来纳州结核病控制项目医学主任的职位所提供的机会完美结合，为受试者招募、为顾问提供临床和流行病学研究培训提供了途径，并有机会根据研究结果实施变革。