Approaches to increase gamma-Globulin Expression in Sickle Cell Disease
Approaches to increase gamma-Globulin Expression in Sickle Cell Disease
批准号:
7538869
负责人:
Gerd A Blobel
金额:
$24.97万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-04-01 至 2008-03-31
关键词:
AdhesionsAdultAdverse effectsAffinityAnimal TestingBenignBindingBiological ModelsBone MarrowButyratesCaliforniaCell LineCell ShapeCellsChromatinChromatin StructureClinicalClinical Course of DiseaseClinical TrialsCollaborationsConditionDNA SequenceDNA-Binding ProteinsDefectDiseaseEffectivenessElementsEmbryoErythrocytesErythroid CellsErythroid Progenitor CellsGamma globulinGene ExpressionGene SilencingGene TransferGenesGenetic TranscriptionGlobinGoalsHematopoieticHemoglobinHistone AcetylationHistone DeacetylationHistonesHumanHypoxiaImidazoleInstitutesIonsLaboratoriesLifeLife ExperienceLigandsLinkMethodsMolecular WeightMusMutationNylonsPatientsPatternPharmaceutical PreparationsPliabilityPoint MutationPolymersPositioning AttributeProteinsPurposePyrrolesResearchResistanceSickle Cell AnemiaSiteSolubilitySpecificityStem cellsTechnologyTestingThinkingTranscriptional Activation DomainTransgenesUmbilical cord structureViralViral VectorWitbutyratedesigndesireembryonic stem cellfetalgene repressionhistone acetyltransferasehydroxyureaimprovedin vivoinhibitor/antagonistmutantnovelpol genesprecursor cellpreventpromoterstemsynthetic constructtherapeutic genetooltranscription factorvector
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海外基金