Approaches to increase gamma-Globulin Expression in Sickle Cell Disease

增加镰状细胞病中丙种球蛋白表达的方法

• 批准号: 7538869
• 负责人: Gerd A Blobel
• 金额: $ 24.97万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7538869
• 关键词: Adhesions; Adult; Adverse effects; Affinity; Animal Testing; Benign; Binding; Biological Models; Bone Marrow; Butyrates; California; Cell Line; Cell Shape; Cells; Chromatin; Chromatin Structure; Clinical; Clinical Course of Disease; Clinical Trials; Collaborations; Condition; DNA Sequence; DNA-Binding Proteins; Defect; Disease; Effectiveness; Elements; Embryo; Erythrocytes; Erythroid Cells; Erythroid Progenitor Cells; Gamma globulin; Gene Expression; Gene Silencing; Gene Transfer; Genes; Genetic Transcription; Globin; Goals; Hematopoietic; Hemoglobin; Histone Acetylation; Histone Deacetylation; Histones; Human; Hypoxia; Imidazole; Institutes; Ions; Laboratories; Life; Life Experience; Ligands; Link; Methods; Molecular Weight; Mus; Mutation; Nylons; Patients; Pattern; Pharmaceutical Preparations; Pliability; Point Mutation; Polymers; Positioning Attribute; Proteins; Purpose; Pyrroles; Research; Resistance; Sickle Cell Anemia; Site; Solubility; Specificity; Stem cells; Technology; Testing; Thinking; Transcriptional Activation Domain; Transgenes; Umbilical cord structure; Viral; Viral Vector; Wit; butyrate; design; desire; embryonic stem cell; fetal; gene repression; histone acetyltransferase; hydroxyurea; improved; in vivo; inhibitor/antagonist; mutant; novel; pol genes; precursor cell; prevent; promoter; stem; synthetic construct; therapeutic gene; tool; transcription factor; vector