Sleep, Symptoms, and Quality of Life in Adolescents during Chemotherapy

青少年化疗期间的睡眠、症状和生活质量

• 批准号: 7274592
• 负责人: Amy J Walker
• 金额: $ 3.5万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7274592
• 关键词: Achievement; Acute; Address; Adolescence; Adolescent; Adolescent Development; Age; Area; Biological; Cancer Center; Characteristics; Chemotherapy-Oncologic Procedure; Child; Chronic Disease; Clinical; Consent; Data; Data Collection; Data Sources; Development; Developmental Process; Diagnosis; Emotional; Family; Fatigue; Future; Gender; Generic Drugs; Goals; Growth; Human; Hygiene; Intervention; Interview; Knowledge; Life; Malignant Neoplasms; Methods; Mission; Morbidity - disease rate; Mucositis; Nausea; Nausea and Vomiting; Outpatients; Pain; Pediatric Hospitals; Phase; Population Research; Preparation; Psychometrics; Public Health; Purpose; Quality of life; Questionnaires; Recruitment Activity; Research; Research Personnel; Sample Size; Sampling; Science; Self Perception; Sleep; Sleep disturbances; Symptoms; actigraphy; base; cancer diagnosis; cancer therapy; cancer type; chemotherapy; coping; critical developmental period; day; design; diaries; experience; improved; innovation; instrument; mortality; nutrition; preadolescence; prospective; psychologic; self esteem; size; social; symptom management

DESCRIPTION (provided by applicant): Specific Aims: The long-term goal of this research is to support the continuing development and improve the quality of life of adolescents with cancer receiving chemotherapy by focusing on symptom management. The purpose of this study is to describe the sleep-wake activity of adolescents undergoing outpatient chemotherapy treatment for cancer, and to explore relationships among sleep, treatment-related symptoms, and quality of life. The primary aim of this study is to describe the sleep-wake activity of adolescents with cancer receiving chemotherapy using multiple sources of data, including actigraphy, a brief "before you were sick" sleep questionnaire, diaries, the Adolescent Sleep-Wake Scale (ASWS), the Adolescent Sleep Hygiene Scale (ASHS), and interview data. Relationships will also be explored based on demographic and clinical characteristics (e.g., age, gender, cancer type, treatment phase). The purpose of the secondary aims is to explore relationships between sleep variables, symptoms, and quality of life, and to generate effect size estimates for future research. This project is relevant to NINR's mission to "understand and ease the symptoms of acute and chronic disease". Additionally, this project focuses on adolescents, an under-researched population, with greater cancer morbidity and mortality than their younger counterparts. Sample: Adolescents, 10-19 years, irrespective of type of cancer or phase of treatment, will be recruited from Legacy Emanuel Children's Hospital (LECH) and Doernbecher Children's Hospital (DCH), the two regional children's cancer centers located in Portland, OR. The anticipated sample size is 50, to be recruited over 8 months. Design and Methods: This is a prospective, cross-sectional, exploratory study. Data will be collected from assenting/consenting adolescents at two points, and the actigraph will be worn continuously for seven days. The first data collection point will involve meeting with the investigator, filling out several psychometric instruments and demographic information. The second data collection point will consist primarily of an interview. Relevance to public health: Adolescents with cancer often have trouble sleeping, in addition to other symptoms such as pain, fatigue, and nausea. Treatment can last for 2-3 years. Therefore, we must understand how to better manage adolescents' symptoms to increase their quality of life and promote healthy adolescent development.

描述(申请人提供)：具体目标：本研究的长期目标是通过注重症状管理来支持接受化疗的青少年癌症患者的持续发展和提高生活质量。本研究的目的是描述接受癌症门诊化疗的青少年的睡眠觉醒活动，并探讨睡眠、治疗相关症状和生活质量之间的关系。这项研究的主要目的是使用多种数据来源描述接受化疗的青少年的睡眠-觉醒活动，包括活动记录仪、一份简短的“生病前”睡眠问卷、日记、青少年睡眠-觉醒量表(ASWS)、青少年睡眠卫生量表(ASHS)和访谈数据。还将根据人口统计和临床特征(例如，年龄、性别、癌症类型、治疗阶段)来探讨相互关系。第二个目标的目的是探索睡眠变量、症状和生活质量之间的关系，并为未来的研究产生效应大小估计。该项目与NINR“了解和缓解急慢性疾病症状”的使命有关。此外，该项目侧重于青少年，这是一个研究不足的人群，与他们的年轻同行相比，他们的癌症发病率和死亡率更高。样本：10-19岁的青少年，无论癌症类型或治疗阶段，将从传统伊曼纽尔儿童医院(LECH)和多恩贝赫儿童医院(DCH)招募，这两家医院位于俄勒冈州波特兰的两个地区性儿童癌症中心。预计抽样人数为50人，将在8个月内招募。设计和方法：这是一项前瞻性、横断面、探索性研究。数据将从同意/同意的青少年中收集在两个点上，活动记录仪将连续佩戴七天。第一个数据收集点将包括与调查人员会面，填写几个心理测量仪和人口统计信息。第二个数据收集点将主要包括一次访谈。与公共健康相关：患有癌症的青少年除了疼痛、疲劳和恶心等其他症状外，通常还会有睡眠困难。治疗可持续2-3年。因此，我们必须了解如何更好地管理青少年的症状，以提高他们的生活质量，促进青少年的健康发展。