The inferior pulvinar and visual attention

下丘脑和视觉注意力

• 批准号: 7166061
• 负责人: CHRISTIN H MCCOOL
• 金额: $ 2.99万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7166061
• 关键词: Area; Attention; Behavioral; Brain; Brain Part; Cell Nucleus; Cells; Condition; Cues; Detection; Discrimination; Drug Formulations; Exhibits; Fellowship; Goals; Image; Individual; Inferior; Lesion; Link; Measures; Medial; Mediating; Motion; Motion Perception; Names; Neurons; Perception; Performance; Photic Stimulation; Play; Process; Pulvinar structure; Role; System; Testing; Thalamic structure; Visual; Visual Cortex; Visual attention; Work; base; design; directed attention; experience; extrastriate; extrastriate visual cortex; forging; relating to nervous system; research study; response; theories; visual process; visual processing

DESCRIPTION (provided by applicant): The pulvinar nucleus is richly interconnected with most of visual cortex, leading many to propose a visual role for this enigmatic part of the brain. However, little is known about its role in visual processing. On the basis of lesion, imaging, and recording studies, it has been proposed that pulvinar plays a role in directing visual attention to particular regions of space. In the proposed experiments, we plan to directly examine this hypothesis using electrical microstimulation and reversible inactivation. We will measure both visual detection performance and neuronal responses in extrastriate cortex, with and without perturbation. The detection task will be of a change in motion direction, and we already know that cortical area MT is involved in this kind of perceptual capability. The design allows two distinct comparisons to be made, each critical to this hypothesis. First, we know that directed attention produces behavioral benefits and local changes in the gain of response of extrastriate neurons; activation of pulvinar should mimic this change and reversible inactivation should eliminate it. Also, we will be able to conclude whether the effects measured perceptually could be mediated through known cortical circuits supporting visual discrimination.

描述（由申请人提供）：枕核与大部分视觉皮层密切相关，导致许多人提出大脑这个神秘部分的视觉作用。然而，很少有人知道它在视觉处理中的作用。在损伤、成像和记录研究的基础上，已经提出枕在将视觉注意力引导到空间的特定区域中起作用。在拟议的实验中，我们计划使用电微刺激和可逆失活直接检验这一假设。我们将测量视觉检测性能和神经元反应的纹外皮层，有和没有扰动。检测任务将是运动方向的变化，我们已经知道皮层区MT参与这种感知能力。该设计允许进行两种不同的比较，每种比较对该假设都至关重要。首先，我们知道定向注意会产生行为益处和纹外神经元反应增益的局部变化;枕的激活应该模仿这种变化，而可逆的失活应该消除它。此外，我们将能够得出结论，感知测量的效果是否可以通过已知的支持视觉辨别的皮质回路来介导。