EXERCISE & ENERGY/SUBSTRATE UTILIZATION IN AFRICAN AMERICANS W/ NIDDM

锻炼

• 批准号: 6263467
• 负责人: DARA P SCHUSTER
• 金额: $ 4.86万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6263467
• 关键词: African American; aerobic exercise; bioenergetics; caucasian American; clinical research; human subject; insulin sensitivity /resistance; noninsulin dependent diabetes mellitus; obesity; racial /ethnic difference; thermogenesis

African Americans have a 2-3 fold higher prevalence of type 2 diabetes mellitus, greater dissease associated morbidity and motality and earlier onset than Caucasian Americans. The etiology of these differences is unclear but has been related to insulin resistance and an increased prevalence of obesity. Thus investigators into racial differences in metabolic and energy aspects of type 2 DM in AA will provide important data on the increased prevalence of both obesity and type 2 DM in the AA population wen compared to CA. The aims of the study include: 1) To examine racial differences in substrate utilization, energy expenditure, insulins sensitivity, glucose effectiveness and beta cell function before and after chronic exercise in AA and CA subjects with type 2 DM, 2) To determine the effects of chronic esercise on the resting metabolic rate (RMR), postprrendial thermogenesis and substrate oxidation in CA and AA subjects with type 2 DM, 3)To compare the effects of resistance vs. aerobic training on substrate oxidation and enerby expenditure and 4) To determine whether the sequential pattern of exercise is associated with different metabolic and energy consequences in CA and AA.

非裔美国人的2型糖尿病患病率是白人的2-3倍，与疾病相关的发病率和死亡率更高，发病时间更早。 这些差异的病因尚不清楚，但与胰岛素抵抗和肥胖患病率增加有关。 因此，研究AA中2型DM代谢和能量方面的种族差异将提供与CA相比AA人群中肥胖和2型DM患病率增加的重要数据。 这项研究的目的包括：1）检测AA和CA 2型DM受试者慢性运动前后底物利用、能量消耗、胰岛素敏感性、葡萄糖有效性和β细胞功能的种族差异，2）确定慢性运动对CA和AA 2型DM受试者静息代谢率（RMR）、餐后产热和底物氧化的影响，3）比较抗阻训练与有氧训练对底物氧化和能量消耗的影响; 4）确定运动的顺序模式是否与CA和AA中不同的代谢和能量结果相关。