EXERCISE & ENERGY/SUBSTRATE UTILIZATION IN AFRICAN AMERICANS W/ NIDDM

锻炼

• 批准号: 6263467
• 负责人: DARA P SCHUSTER
• 金额: $ 4.86万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6263467
• 关键词: African American; aerobic exercise; bioenergetics; caucasian American; clinical research; human subject; insulin sensitivity /resistance; noninsulin dependent diabetes mellitus; obesity; racial /ethnic difference; thermogenesis

African Americans have a 2-3 fold higher prevalence of type 2 diabetes mellitus, greater dissease associated morbidity and motality and earlier onset than Caucasian Americans. The etiology of these differences is unclear but has been related to insulin resistance and an increased prevalence of obesity. Thus investigators into racial differences in metabolic and energy aspects of type 2 DM in AA will provide important data on the increased prevalence of both obesity and type 2 DM in the AA population wen compared to CA. The aims of the study include: 1) To examine racial differences in substrate utilization, energy expenditure, insulins sensitivity, glucose effectiveness and beta cell function before and after chronic exercise in AA and CA subjects with type 2 DM, 2) To determine the effects of chronic esercise on the resting metabolic rate (RMR), postprrendial thermogenesis and substrate oxidation in CA and AA subjects with type 2 DM, 3)To compare the effects of resistance vs. aerobic training on substrate oxidation and enerby expenditure and 4) To determine whether the sequential pattern of exercise is associated with different metabolic and energy consequences in CA and AA.

非洲裔美国人的患病率比高加索美国人高2型糖尿病，相关的发病率和更早的发病率更高，并且发病较早。 这些差异的病因尚不清楚，但与胰岛素抵抗和肥胖症患病率的增加有关。 因此，研究人员研究了AA中2型DM代谢和能量方面的种族差异，将提供有关AA种群WEN中肥胖和2型DM患病率增加的重要数据，与CA相比。 该研究的目的包括：1）检查底物利用，能量消耗，胰岛素敏感性，葡萄糖敏感性，葡萄糖有效性和β细胞功能在慢性运动前后的AA和CA受试者之前和之后的2型dm，2）确定持续的杂物对静止代谢率（RMR）的影响（RMR）的影响（RMR）的影响（RMR），并确定一定的氧化（RMR）的影响（RMR）。 DM，3）比较耐药性与有氧训练对底物氧化和能量支出的影响，以及4）确定锻炼的顺序模式是否与CA和AA中的不同代谢和能量后果有关。