MENOPAUSAL SYMPTOMS AND METABOLIC SYNDROME: A FEASIBILITY STUDY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 更年期相关症状，特别是潮热和盗汗，人们对之知之甚少，而且几乎没有有效的治疗方法，因为妇女健康倡议（WHI）的发现提高了人们对使用激素/雌激素治疗这些症状的风险的认识。睡眠障碍与夜间潮热和生理唤醒指数有关（例如，皮质醇升高、胰岛素抵抗、自主神经张力升高和炎症过程），可能导致代谢综合征体征的发展，这些体征在绝经过渡期间出现，并与绝经后心血管疾病（CVD）风险升高相关。心血管疾病是老年妇女严重残疾和死亡的主要原因。减少更年期症状和改善睡眠的干预措施是必要的，但为了设计它们，有必要了解潮热，睡眠障碍，生理反应之间的关系，以及心理社会因素调节这些关系的方式（例如，敌意/愤怒）。我们重新提交了一项纵向研究，以描述潮热、睡眠障碍和代谢综合征指标之间的关系，以及在潮热和睡眠障碍发生率最高的围绝经期晚期和绝经后最初几年，应激反应和心理社会因素如何调节这些关系（1 R 01 NR 009365 -01）。来自护理科学成人和老年人研究部分的评审员要求提供方案完成的可行性数据。因此，本研究的目的是记录在5名女性中实施我们的17天研究方案的可行性，以便我们重新提交。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Menopause-related symptoms, especially hot flashes and night sweats, are poorly understood and few effective therapeutics exist since the Women's Health Initiative (WHI) findings heightened awareness of the risks of using hormones/estrogen to treat them. Sleep disturbance has been linked to nocturnal hot flashes and to indices of physiological arousal (e.g., elevated cortisol, insulin resistance, heightened autonomic tone, and inflammatory processes) that could contribute to development of metabolic syndrome signs that emerge during the menopause transition and is associated with elevated cardiovascular disease (CVD) risk after menopause. CVD is the leading cause of significant disability and death in older women. Interventions to reduce menopausal symptoms and improve sleep are needed but in order to design them, it is necessary to understand the relations among hot flashes, sleep disturbance, physiological reactivity, and the way psychosocial factors moderate these relations (e.g., hostility/anger). We are re-submitting a longitudinal study to describe relations among hot flashes, sleep disturbance, and indicators of metabolic syndrome, and how stress reactivity and psychosocial factors moderate these relations in late perimenopause and the first few years postmenopause when the incidence of hot flashes and sleep disturbance is highest (1 R01 NR009365-01). Reviewers from the Nursing Science Adult and Older Adult study section requested feasibility data of protocol completion. Thus, the purpose of this study is to document the feasibility of implementing our 17-day study protocol in 5 women for our resubmission.