SLEEP IN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。幼年类风湿性关节炎(JRA)是儿童时期最常见的一种关节炎，是一种病因不明的疾病，其病程多种多样，以间歇性缓解和加重为特征。最近的研究结果表明，患有JRA的儿童睡眠受到干扰。在这一脆弱的人群中，睡眠障碍包括入睡困难、保持睡眠、清晨醒来和白天过度困倦。目前，我们不知道JRA儿童睡眠障碍的严重程度，也不知道睡眠障碍在多大程度上会导致白天的嗜睡、疲劳和表现受损。我们最近对JRA儿童睡眠模式的纵向研究表明，在关节炎发作期间，睡眠障碍更有可能发生。睡眠质量可能是儿童如何经历这种疾病症状的一个重要预测因素，但这一点还没有报道，或者只是未知。这项研究的目的是评估JRA儿童在关节炎发作一周或缓解一周期间的睡眠、日间嗜睡、表现和症状体验。这项研究的结果将为设计后续干预研究以提高慢性疼痛儿童的睡眠质量提供基础

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Juvenile rheumatoid arthritis (JRA), the most prevalent form of arthritis in childhood, is a disease of unknown etiology, and its course is variable and characterized by episodic remissions and exacerbations. Recent findings suggest that sleep is disrupted in children with JRA. Sleep disturbances in this vulnerable population include difficulty falling asleep, staying asleep, early morning awakening, and excessive daytime sleepiness. At present, we do not know the severity of disturbed sleep in children with JRA, nor do we understand how much disturbed sleep contributes to daytime sleepiness, fatigue, and impaired performance. Our recent longitudinal study of sleep patterns in children with JRA suggests that sleep disturbances are more likely to occur during periods of arthritic flare. Sleep quality may be an important predictor of how children experience symptoms of the disease, but this has not been reported, or is simply unknown. The purpose of this study is to assess sleep, daytime sleepiness, performance and symptom experience in children with JRA during a week of arthritic flare or during a week of remission. Findings from this study will provide the foundation for designing subsequent intervention studies to enhance the quality of sleep in children living with chronic pain