Valerian for Sleep Disturbance in Healthy Older Adults
缬草治疗健康老年人的睡眠障碍
基本信息
- 批准号:6891701
- 负责人:
- 金额:$ 18.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-05-15 至 2008-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): Sleep disturbances are very common in the elderly. As many as 40% of older adults complain about sleep problems, including inability to fall asleep quickly, frequent nocturnal awakenings, or early morning awakenings. Untreated sleep disturbances may increase the risk for depression and early mortality. Older adults frequently use prescription hypnotic and over-the-counter medications as sleep aids, despite observations these drugs further disrupt sleep patterns and have untoward side effects. Herbal medicines as dietary supplements are already quite popular and likely to be used by increasing numbers of adults in the next few decades. Alternative herbal medicines, such as valerian, which was in the top 20 best selling herbal products in the United States in 2001, have the potential to enhance sleep but their efficacy needs to be established in older adults. Valerian contains a variety of compounds including valerenic acid and its derivatives. The pharmacokinetic properties of the valerian constituents have not been reported and there is nothing known about the pharmacokinetic properties of valerian constituents in relation to objective sleep measures. A limited literature of small-sample placebo-controlled trials suggests that valerian may improve sleep and has a very low rate of side effects. The specific aims of this preliminary study are to determine the sleep enhancing effects of a recommended dose of valerian and to describe its pharmacokinetic properties in older adults with a complaint of sleep disturbance. We have developed an assay for valerenic acid and will describe the pharmacokinetics of valerian after a single dose and at steady state following two weeks of continuous treatment and relate the sleep enhancing effects as shown by polysomnography to valerian PK. Our working hypothesis is that valerian will enhance sleep after two weeks of daily nighttime dosing (chronic), but is not likely to enhance sleep after a single dose (acute). The design will be a single group, double-blind, placebo controlled cross-over trial in 20 relatively healthy older adult women and men, 55 to 80 years old. We expect the study outcomes will provide preliminary data in support of a large randomized clinical trial of valerian effects on subjective and objective sleep quality in older adults.
描述(由申请人提供):睡眠障碍在老年人中非常常见。多达40%的老年人抱怨睡眠问题,包括无法快速入睡,夜间频繁醒来或清晨醒来。未经治疗的睡眠障碍可能会增加抑郁症和早期死亡的风险。老年人经常使用处方催眠药和非处方药作为睡眠辅助剂,尽管观察到这些药物会进一步扰乱睡眠模式并产生不良副作用。草药作为膳食补充剂已经非常受欢迎,并且在未来几十年内可能会被越来越多的成年人使用。替代草药,如2001年美国最畅销的20种草药产品之一的缬草,有可能增强睡眠,但其疗效需要在老年人中确定。缬草含有多种化合物,包括缬草酸及其衍生物。尚未报道缬属成分的药代动力学特性,并且对于缬属成分与客观睡眠测量相关的药代动力学特性一无所知。小样本安慰剂对照试验的有限文献表明,缬草可以改善睡眠,副作用发生率非常低。这项初步研究的具体目的是确定推荐剂量的缬草根的睡眠增强作用,并描述其在患有睡眠障碍的老年人中的药代动力学特性。我们已经开发了一种缬草酸的测定方法,并将描述单次给药后和连续治疗两周后稳态时缬草酸的药代动力学,并将多导睡眠图显示的睡眠增强作用与缬草酸PK联系起来。我们的工作假设是,每天晚上服用两周后,缬草根会增强睡眠(慢性),但单次服用后不太可能增强睡眠(急性)。该设计将是一项单组、双盲、安慰剂对照的交叉试验,在20名相对健康的55至80岁的老年女性和男性中进行。我们希望研究结果将提供初步数据,支持一项大型随机临床试验,研究缬草根对老年人主观和客观睡眠质量的影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
CAROL A LANDIS其他文献
CAROL A LANDIS的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('CAROL A LANDIS', 18)}}的其他基金
MENOPAUSAL SYMPTOMS AND METABOLIC SYNDROME: A FEASIBILITY STUDY
更年期症状和代谢综合征:可行性研究
- 批准号:
7603487 - 财政年份:2007
- 资助金额:
$ 18.95万 - 项目类别:
SLEEP IN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS
患有幼年类风湿性关节炎的儿童的睡眠
- 批准号:
7603528 - 财政年份:2007
- 资助金额:
$ 18.95万 - 项目类别:
SLEEP IN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS
患有幼年类风湿性关节炎的儿童的睡眠
- 批准号:
7379408 - 财政年份:2006
- 资助金额:
$ 18.95万 - 项目类别:
SLEEP IN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS
患有幼年类风湿性关节炎的儿童的睡眠
- 批准号:
7198911 - 财政年份:2005
- 资助金额:
$ 18.95万 - 项目类别:
Valerian for Sleep Disturbance in Healthy Older Adults
缬草治疗健康老年人的睡眠障碍
- 批准号:
6756154 - 财政年份:2004
- 资助金额:
$ 18.95万 - 项目类别:
SLEEP IN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS
患有幼年类风湿性关节炎的儿童的睡眠
- 批准号:
7076919 - 财政年份:2003
- 资助金额:
$ 18.95万 - 项目类别:
SLEEP IN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS
患有幼年类风湿性关节炎的儿童的睡眠
- 批准号:
6618644 - 财政年份:2003
- 资助金额:
$ 18.95万 - 项目类别:
SLEEP IN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS
患有幼年类风湿性关节炎的儿童的睡眠
- 批准号:
6792637 - 财政年份:2003
- 资助金额:
$ 18.95万 - 项目类别:
SLEEP IN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS
患有幼年类风湿性关节炎的儿童的睡眠
- 批准号:
6900968 - 财政年份:2003
- 资助金额:
$ 18.95万 - 项目类别:
相似海外基金
Complementary and alternative medicine for drug-induced gingival overgrowth: inhibitory effect of TRPA1 channel by lutein
药物性牙龈增生的补充和替代医学:叶黄素对 TRPA1 通道的抑制作用
- 批准号:
23K09321 - 财政年份:2023
- 资助金额:
$ 18.95万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Complementary alternative medicine contributes to attenuate orofacial pain: anesthetic and anti-inflammatory effects of phytochemical
补充替代医学有助于减轻口面部疼痛:植物化学物质的麻醉和抗炎作用
- 批准号:
22K10232 - 财政年份:2022
- 资助金额:
$ 18.95万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Negotiating distinctions between conventional and alternative medicine in the English- and French-language Wikipedias
英语和法语维基百科中讨论传统医学和替代医学之间的区别
- 批准号:
AH/V013203/1 - 财政年份:2021
- 资助金额:
$ 18.95万 - 项目类别:
Research Grant
Systematic study on legal regulations for complementary and alternative medicine
补充替代医学法律法规的系统研究
- 批准号:
19K21680 - 财政年份:2019
- 资助金额:
$ 18.95万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Contribution of complementary alternative medicine to the orthodontic tooth-movement induced inflammatory pain: a possible role of dietary constituent
补充替代医学对正畸牙齿移动引起的炎症性疼痛的贡献:饮食成分的可能作用
- 批准号:
19K10415 - 财政年份:2019
- 资助金额:
$ 18.95万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Application of complementary and alternative medicine for breast cancer based on kinetic characteristics of food components
基于食物成分动力学特征的乳腺癌补充替代医学应用
- 批准号:
18K14416 - 财政年份:2018
- 资助金额:
$ 18.95万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Elucidation of the Mechanism of Care Effectiveness Using Complementary and Alternative Medicine Material Detergent for Radiation Skin Damage
阐明补充和替代药物材料清洁剂对放射性皮肤损伤的护理效果机制
- 批准号:
18K17460 - 财政年份:2018
- 资助金额:
$ 18.95万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Quality of clinical research papers on complementary and alternative medicine: evaluation with modified systematic reviews
补充和替代医学临床研究论文的质量:用修改后的系统评价进行评估
- 批准号:
17K08938 - 财政年份:2017
- 资助金额:
$ 18.95万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Formulation for the Application of the Energy Therapy "Reiki" as Complementary and Alternative Medicine for Cancer Patient
应用能量疗法“灵气”作为癌症患者的补充和替代医学的配方
- 批准号:
16K15906 - 财政年份:2016
- 资助金额:
$ 18.95万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Boundaries between Orthodox Medicine and Alternative Medicine
正统医学与替代医学之间的界限
- 批准号:
16K21422 - 财政年份:2016
- 资助金额:
$ 18.95万 - 项目类别:
Grant-in-Aid for Young Scientists (B)