IRON DEPLETION THERAPY FOR PTS WITH TYPE 2 DM AND NAFLD

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项先导性研究的目的是确定缺铁对2型糖尿病和非酒精性脂肪性肝病患者胰岛素敏感性的影响。次要结果指标将包括铁缺乏对肝脏坏死性炎症、氧化应激标志物和肝内脂肪含量的影响。胰岛素抵抗将使用两步高胰岛素正血糖钳夹程序直接测量，通过静脉切开来耗尽铁。还将进行口服葡萄糖耐量试验，以评估使用间接但不那么繁琐的HOMA模型在该患者队列中得出胰岛素抵抗值的有效性。这项研究将促进我们对体内铁储存在2型糖尿病和非酒精性脂肪性肝病的病理生理中的作用的理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this pilot study is to determine the effect of iron depletion on insulin sensitivity in patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease. Secondary outcome measures will include the effect of iron depletion on hepatic necroinflammation, markers of oxidative stress and intrahepatic fat content. Insulin resistance will be directly measured using a two-step hyperinsulinemic euglycemic clamp procedure, before and after iron depletion by phlebotomy. Oral glucose tolerance tests will also be performed in order to evaluate the efficacy of using the indirect, but less cumbersome, HOMA model to derive values of insulin resistance in this patient cohort. This study will advance our understanding of the role of body iron stores in the pathophysiology of type 2 diabetes mellitus and non-alcoholic fatty liver disease