A RANDOMIZED, MASKED, CONTROLLED STUDY OF OMEGA-3 POLYUNSATURATED FATTY ACID

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Omega-3-polyunsaturated fatty acids have been shown to simultaneously suppress hepatic lipid synthesis while upregulating fatty acid oxidation. Numerous clinical studies using dietary supplementation with omega-3 polyunsaturated fatty acids (PUFA) have resulted in decreased VLDL cholesterol and serum trigylcerides. However a detailed clinical study evaluating the effects of omega-3-PUFA on hepatic steatosis in patients with non-alcoholic fatty liver disease has not been performed. This proposal is to perform a parallel, placebo-controlled study to determine the effects of dietary supplementation with omega-3 PUFA in patients with non-alcoholic fatty liver disease. The primary outcome measure of this study will be the reduction of intrahepatic fat content as determined by magnetic resonance spectroscopy. The effects of omega-3-PUFA on hepatic necroinflammation, blood pressure, serum markers of inflammation, insulin sensitivity and fatty acid oxidation will also be analyzed.