The Role of Iron in the Pathogenesis of NAFLD

铁在 NAFLD 发病机制中的作用

• 批准号: 8084299
• 负责人: KRIS KOWDLEY
• 金额: $ 44.14万
• 依托单位: BENAROYA RESEARCH INST AT VIRGINIA MASON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-28 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8084299
• 关键词: Adult; Affect; Aftercare; Age; Alcohol consumption; American; Ancillary Study; Apoptosis; Area; Biological Assay; Biology; Biopsy; Blinded; Cardiovascular Diseases; Cells; Child; Chronic; Cirrhosis; Clinical; Clinical Data; Clinical Research; DNA; Data; Data Coordinating Center; Databases; Deposition; Diabetes Mellitus; Diagnosis; Dietary Iron; Disease; Disease Progression; Down-Regulation; Enrollment; Environmental Risk Factor; Fatty Liver; Fatty acid glycerol esters; Feasibility Studies; Fibrosis; Food; Frequencies; Funding; Gender; Gene Expression; Gene-Modified; General Population; Genes; Genetic Polymorphism; Goals; Hemochromatosis; Hepatic; Hepatic Fibrogenesis; Hepatic Stellate Cell; Histologic; IL8 gene; Immunohistochemistry; In Situ; Inflammation; Inflammatory; Injury; Insulin Resistance; Interleukin-6; International; Iron; Iron Overload; Kupffer Cells; Laboratories; Lead; Liver; Liver diseases; Matched Case-Control Study; Methods; Molecular Profiling; Mutation; National Institute of Diabetes and Digestive and Kidney Diseases; Natural History; Nonesterified Fatty Acids; North America; Nuclear; Oxidation-Reduction; Oxidative Stress; Pathogenesis; Pathway interactions; Patients; Pattern; Peptides; Performance; Phenotype; Production; Publishing; Questionnaires; Randomized Clinical Trials; Reactive Oxygen Species; Regression Analysis; Regulation; Regulator Genes; Resources; Risk; Risk Factors; Role; Serum; Severities; Severity of illness; Site; Slide; Societies; Staging; Staining method; Stains; Steatohepatitis; TFR2 gene; Time; Tissues; Transforming Growth Factors; Translational Research; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Up-Regulation; Visceral; Work; absorption; cytokine; cytotoxic; disease natural history; effective therapy; fibrogenesis; follow-up; hepcidin; interest; liver biopsy; macrophage; mitochondrial dysfunction; non-alcoholic fatty liver; nonalcoholic steatohepatitis; novel; prospective; sobriety; stellate cell; success; symposium