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The Role of Iron in the Pathogenesis of NAFLD

The Role of Iron in the Pathogenesis of NAFLD
铁在 NAFLD 发病机制中的作用
批准号：
8084299
负责人：
KRIS KOWDLEY
金额：
$44.14万
依托单位：
BENAROYA RESEARCH INST AT VIRGINIA MASON
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-07-28 至 2011-07-31
来源：
https://reporter.nih.gov/project-details/8084299
关键词：
AdultAffectAftercareAgeAlcohol consumptionAmericanAncillary StudyApoptosisAreaBiological AssayBiologyBiopsyBlindedCardiovascular DiseasesCellsChildChronicCirrhosisClinicalClinical DataClinical ResearchDNADataData Coordinating CenterDatabasesDepositionDiabetes MellitusDiagnosisDietary IronDiseaseDisease ProgressionDown-RegulationEnrollmentEnvironmental Risk FactorFatty LiverFatty acid glycerol estersFeasibility StudiesFibrosisFoodFrequenciesFundingGenderGene ExpressionGene-ModifiedGeneral PopulationGenesGenetic PolymorphismGoalsHemochromatosisHepaticHepatic FibrogenesisHepatic Stellate CellHistologicIL8 geneImmunohistochemistryIn SituInflammationInflammatoryInjuryInsulin ResistanceInterleukin-6InternationalIronIron OverloadKupffer CellsLaboratoriesLeadLiverLiver diseasesMatched Case-Control StudyMethodsMolecular ProfilingMutationNational Institute of Diabetes and Digestive and Kidney DiseasesNatural HistoryNonesterified Fatty AcidsNorth AmericaNuclearOxidation-ReductionOxidative StressPathogenesisPathway interactionsPatientsPatternPeptidesPerformancePhenotypeProductionPublishingQuestionnairesRandomized Clinical TrialsReactive Oxygen SpeciesRegression AnalysisRegulationRegulator GenesResourcesRiskRisk FactorsRoleSerumSeveritiesSeverity of illnessSiteSlideSocietiesStagingStaining methodStainsSteatohepatitisTFR2 geneTimeTissuesTransforming Growth FactorsTranslational ResearchTumor Necrosis Factor-alphaTumor Necrosis FactorsUp-RegulationVisceralWorkabsorptioncytokinecytotoxicdisease natural historyeffective therapyfibrogenesisfollow-uphepcidininterestliver biopsymacrophagemitochondrial dysfunctionnon-alcoholic fatty livernonalcoholic steatohepatitisnovelprospectivesobrietystellate cellsuccesssymposium

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The Role of Iron in the Pathogenesis of NAFLD
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